Liu, Xuedong - University of Colorado - Chemistry and Biochemistry

个人简介

Ph.D.: University of Wisconsin-Madison, 1994 Postdoctoral Fellow: NIH Fellow at Whitehead Institute/MIT, 1995-1998 DOD/US Army Breast Cancer Research Postdoctoral Fellow at Whitehead Institute, 1998-2000

研究领域

Cell Signaling Renewable Energy

Research Profile Ongoing projects include the following: 1) Systems biology of TGF-β signaling in normal and cancer cells 2) Chemical biology and biochemistry of the ubiquitin system 3) Mps1 kinase and spindle checkpoint signaling 4) Cis-regulatory transcriptional regulation

近期论文

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Zi, Z., D.A. Chapnick, and X. Liu, Dynamics of TGF-beta/Smad Signaling. FEBS Lett, 586 (2012) 1921–1928.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=22710166 Ungermannova, D., S.J. Parker, C.G. Nasveschuk, W. Wang, B. Quade, G. Zhang, R.D. Kuchta, A.J. Phillips, and X. Liu, Largazole and Its Derivatives Selectively Inhibit Ubiquitin Activating Enzyme (E1). PLoS One, 2012. 7(1): p. e29208.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=22279528 Ungermannova, D., S.J. Parker, C.G. Nasveschuk, D.A. Chapnick, A.J. Phillips, R.D. Kuchta, and X. Liu, Identification and Mechanistic Studies of a Novel Ubiquitin E1 Inhibitor. J Biomol Screen, 2012. 17(4): p. 421-34.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=22274912 Liu, X. and M. Winey, The Mps1 Family of Protein Kinases. Annu Rev Biochem, 2012. 81: p. 561-85.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=22482908 Zi, Z., Z. Feng, D.A. Chapnick, M. Dahl, D. Deng, E. Klipp, A. Moustakas, and X. Liu, Quantitative Analysis of Transient and Sustained Transforming Growth Factor-Beta Signaling Dynamics. Mol Syst Biol, 2011. 7: p. 492.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21613981 Zhang, X., Q. Yin, Y. Ling, Y. Zhang, R. Ma, Q. Ma, C. Cao, H. Zhong, X. Liu, and Q. Xu, Two Lxxll Motifs in the N Terminus of Mps1 Are Required for Mps1 Nuclear Import During G(2)/M Transition and Sustained Spindle Checkpoint Responses. Cell Cycle, 2011. 10(16): p. 2742-50.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21778823 He, J., J. Ye, Y. Cai, C. Riquelme, J.O. Liu, X. Liu, A. Han, and L. Chen, Structure of P300 Bound to Mef2 on DNA Reveals a Mechanism of Enhanceosome Assembly. Nucleic Acids Res, 2011. 39(10): p. 4464-74.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21278418 Chapnick, D.A., L. Warner, J. Bernet, T. Rao, and X. Liu, Partners in Crime: Tgf-Beta and Mapk Pathways in Cancer Progression. Cell Biosci, 2011. 1(1): p. 42.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=22204556 Zhong, J., X. Liu, and A. Pandey, Effects of Transmembrane and Juxtamembrane Domains on Proliferative Ability of Tslp Receptor. Mol Immunol, 2010. 47(6): p. 1207-15.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20096461 Zeng, Z., W. Wang, Y. Yang, Y. Chen, X. Yang, J.A. Diehl, X. Liu*, and M. Lei*, Structural Basis of Selective Ubiquitination of Trf1 by Scffbx4. Dev Cell, 2010. 18(2): p. 214-25. * Corresponding authors.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20159592 Sun, T., X. Yang, W. Wang, X. Zhang, Q. Xu, S. Zhu, R. Kuchta, G. Chen, and X. Liu, Cellular Abundance of Mps1 and the Role of Its Carboxyl Terminal Tail in Substrate Recruitment. J Biol Chem, 2010. 285(49): p. 38730-9.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20884615 Clarke, D.C. and X. Liu, Measuring the Absolute Abundance of the Smad Transcription Factors Using Quantitative Immunoblotting. Methods Mol Biol, 2010. 647: p. 357-76.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20694679 Chapnick, D.A. and X. Liu, Analysis of Ligand-Dependent Nuclear Accumulation of Smads in Tgf-Beta Signaling. Methods Mol Biol, 2010. 647: p. 95-111.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20694662 Xu, Q., S. Zhu, W. Wang, X. Zhang, W. Old, N. Ahn, and X. Liu, Regulation of Kinetochore Recruitment of Two Essential Mitotic Spindle Checkpoint Proteins by Mps1 Phosphorylation. Mol Biol Cell, 2009. 20(1): p. 10-20.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18923149 Wang, W., Y. Yang, Y. Gao, Q. Xu, F. Wang, S. Zhu, W. Old, K. Resing, N. Ahn, M. Lei*, and X. Liu*, Structural and Mechanistic Insights into Mps1 Kinase Activation. J Cell Mol Med, 2009. 13(8B): p. 1679-94. *corresponding authors.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19120698 Granovsky, A.E., M.C. Clark, D. McElheny, G. Heil, J. Hong, X. Liu, Y. Kim, G. Joachimiak, A. Joachimiak, S. Koide, and M.R. Rosner, Raf Kinase Inhibitory Protein Function Is Regulated Via a Flexible Pocket and Novel Phosphorylation-Dependent Mechanism. Mol Cell Biol, 2009. 29(5): p. 1306-20.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19103740 Erickson, R.A. and X. Liu, Association of V-Erba with Smad4 Disrupts Tgf-Beta Signaling. Mol Biol Cell, 2009. 20(5): p. 1509-19.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19144825 Clarke, D.C., M.L. Brown, R.A. Erickson, Y. Shi, and X. Liu, Transforming Growth Factor Beta Depletion Is the Primary Determinant of Smad Signaling Kinetics. Mol Cell Biol, 2009. 29(9): p. 2443-55.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19223462 Nasveschuk, C.G., D. Ungermannova, X. Liu, and A.J. Phillips, A Concise Total Synthesis of Largazole, Solution Structure, and Some Preliminary Structure Activity Relationships. Org Lett, 2008. 10(16): p. 3595-8.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18616341 Guo, X., D.S. Waddell, W. Wang, Z. Wang, N.T. Liberati, S. Yong, X. Liu, and X.F. Wang, Ligand-Dependent Ubiquitination of Smad3 Is Regulated by Casein Kinase 1 Gamma 2, an Inhibitor of Tgf-Beta Signaling. Oncogene, 2008. 27(58): p. 7235-47.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18794808 Guo, X., A. Ramirez, D.S. Waddell, Z. Li, X. Liu, and X.F. Wang, Axin and Gsk3- Control Smad3 Protein Stability and Modulate Tgf- Signaling. Genes Dev, 2008. 22(1): p. 106-20.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18172167 Clarke, D.C. and X. Liu, Decoding the Quantitative Nature of Tgf-Beta/Smad Signaling. Trends Cell Biol, 2008. 18(9): p. 430-42.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18706811 Barthel, K.K. and X. Liu, A Transcriptional Enhancer from the Coding Region of Adamts5. PLoS ONE, 2008. 3(5): p. e2184.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18478108 Zhu, S., W. Wang, D.C. Clarke, and X. Liu, Activation of Mps1 Promotes Transforming Growth Factor-Beta-Independent Smad Signaling. J Biol Chem, 2007. 282(25): p. 18327-38.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17452325 Zhang, L., L. Ding, T.H. Cheung, M.Q. Dong, J. Chen, A.K. Sewell, X. Liu, J.R. Yates, 3rd, and M. Han, Systematic Identification of C. Elegans Mirisc Proteins, Mirnas, and Mrna Targets by Their Interactions with Gw182 Proteins Ain-1 and Ain-2. Mol Cell, 2007. 28(4): p. 598-613.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18042455