Zhao, Chunxia - The University of Queensland - Australian Institute for Bioengineering and Nanotechnology

个人简介

Associate Professor Chun-Xia Zhao is a Group leader and an Australian Research Council (ARC) Future Fellow and at AIBN. She joined Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland (UQ) in early 2008 as a Postdoctoral Fellow in Prof. Anton Middelberg's group, after obtained her PhD degree in Zhejiang University. In 2011, A/Prof. Zhao was awarded an ARC Discovery project along with the Australian Postdoctoral Fellow as the sole investigator. In 2014, she was awarded the prestigious Australian Research Council Future Fellow. Her research in bio-inspired nanotechnology and microfluidics has attracted more than $3.5 M research funding since 2011, including three Australian Research Council projects (two ARC discovery projects and one ARC Linkage project) as the lead investigator, two national prestigious fellowship (Australian Postdoctoral Fellowship and Australian Research Council Future Fellowship), UQ Early Career Award and UQ New Staff Start-Up grant. She visited Harvard University as Fellow of the School of Engineering and Applied Science (Oct - Dec, 2014). In 2016, her research excellence was recognised by the UQ Foundation Research Excellence Award. She has been appointed as member of the 2019 ARC College of Experts (2019-2021). A/Prof. Zhao has contributed substantial high quality scientific papers in international top refereed journals such as Angewandte Chemie International Edition, Chemical Communications, Journal of Materials Chemistry, AIChE Journal, Biotechnology and Bioengineering, Vaccine, and so on. She has been focusing on innovative research, and has been active in patent application to transfer her research into practical applications, as evidenced by her five patents. One of her patents was licensed to an international company. She has built extensive collaborations with scientists at top universities such as Harvard University, Brown University, etc. She serves as the Editor-in-Chief, Editorial Board member for several journals.

研究领域

Multifunctional nanomaterials for drug delivery, vaccine delivery and controlled release Dr Zhao's research expertise is nanomaterials for drug delivery and controlled release, microfluidics for making sophisticated materials and screening drug delivery systems, and biomolecular engineering for sustainable materials, including a number of directions: (1) Emulsion and biomimetic dual-templating technology for making silica capsules for controlled and sustained release; (2) Stimuli-responsive soft materials based on biomolecules manufactured from renewable resources. (3) Simple and low-cost platform technology for producing bioproducts, including peptide or protein biosurfactants, peptide antibiotics. (4) Microfluidic synthesis of hierarchical materials for applications in sustained and controlled drug release. (5) Microfluidic platform technology for reproducibly producing targeted polymer nanocarriers having systematically varied properties. (6) In vivo-mimicking Tissue Chips for screening and evaluating nanocarriers.

近期论文

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J-aggregate-based FRET monitoring of drug release from polymer nanoparticles with high drug loading Liu, Yun, Yang, Guangze, Jin, Song, Zhang, Run, Chen, Peng, Jisi, Teng, Wang, Lianzhou, Chen, Dong, Weitz, David and Zhao, Chun-Xia (2020). J-aggregate-based FRET monitoring of drug release from polymer nanoparticles with high drug loading. Angewandte Chemie anie.202008018 doi: 10.1002/anie.202008018 Active encapsulation in biocompatible nanocapsules Wu, Baiheng, Yang, Chenjing, Li, Bo, Feng, Leyun, Hai, Mingtan, Zhao, Chun-Xia, Chen, Dong, Liu, Kai and Weitz, David A. (2020). Active encapsulation in biocompatible nanocapsules. Small, 16 (30) 2002716, 1-7. doi: 10.1002/smll.202002716 Nanoparticle elasticity regulates phagocytosis and cancer cell uptake Hui, Yue, Yi, Xin, Wibowo, David, Yang, Guangze, Middelberg, Anton P. J., Gao, Huajian and Zhao, Chun-Xia (2020). Nanoparticle elasticity regulates phagocytosis and cancer cell uptake. Science Advances, 6 (16) eaaz4316, eaaz4316. doi: 10.1126/sciadv.aaz4316 Stable polymer nanoparticles with exceptionally high drug loading by sequential nanoprecipitation Liu, Yun, Yang, Guangze, Baby, Thejus, Tengjisi, Chen, Dong, Weitz, David A. and Zhao, Chun-Xia (2020). Stable polymer nanoparticles with exceptionally high drug loading by sequential nanoprecipitation. Angewandte Chemie International Edition, 59 (12) ange.201913539, 4720-4728. doi: 10.1002/anie.201913539 Bioinspired core-shell nanoparticles for hydrophobic drug delivery Yang, Guangze, Liu, Yun, Wang, Haofei, Wilson, Russell, Hui, Yue, Yu, Lei, Wibowo, David, Zhang, Cheng, Whittaker, Andrew K., Middelberg, Anton P. J. and Zhao, Chun-Xia (2019). Bioinspired core-shell nanoparticles for hydrophobic drug delivery. Angewandte Chemie (International Edition), 58 (40) ange.201908357, 14357-14364. doi: 10.1002/anie.201908357 Role of nanoparticle mechanical properties in cancer drug delivery Hui, Yue, Yi, Xin, Hou, Fei, Wibowo, David, Zhang, Fan, Zhao, Dongyuan, Gao, Huajian and Zhao, Chun-Xia (2019). Role of nanoparticle mechanical properties in cancer drug delivery. ACS Nano, 13 (7) acsnano.9b03924, 7410-7424. doi: 10.1021/acsnano.9b03924 Controlled co-precipitation of biocompatible colorant-loaded nanoparticles by microfluidics for natural color drinks Kong, Linlin, Chen, Ran, Wang, Xingzheng, Zhao, Chun-Xia, Chen, Qiushui, Hai, Mingtan, Chen, Dong, Yang, Zhenzhong and Weitz, David A. (2019). Controlled co-precipitation of biocompatible colorant-loaded nanoparticles by microfluidics for natural color drinks. Lab on a Chip, 19 (12), 2089-2095. doi: 10.1039/c9lc00240e A microfluidic tumor-on-a-chip for assessing multifunctional liposomes' tumor targeting and anticancer efficacy Ran, Rui, Wang, Hao-Fei, Hou, Fei, Liu, Yun, Hui, Yue, Petrovsky, Nikolai, Zhang, Fan and Zhao, Chun-Xia (2019). A microfluidic tumor-on-a-chip for assessing multifunctional liposomes' tumor targeting and anticancer efficacy. Advanced Healthcare Materials, 8 (8) 1900015, e1900015. doi: 10.1002/adhm.201900015 Tumor-vasculature-on-a-chip for investigating nanoparticle extravasation and tumor accumulation Wang, Hao-Fei, Ran, Rui, Liu, Yun, Hui, Yue, Zeng, Bijun, Chen, Dong, Weitz, David A. and Zhao, Chun-Xia (2018). Tumor-vasculature-on-a-chip for investigating nanoparticle extravasation and tumor accumulation. ACS Nano, 12 (11) acsnano.8b06846, 11600-11609. doi: 10.1021/acsnano.8b06846 Microfluidic formation of coculture tumor spheroids with stromal cells as a novel 3D tumor model for drug testing Sun, Qi, Tan, Say Hwa, Chen, Qiushui, Ran, Rui, Hui, Yue, Chen, Dong and Zhao, Chun-Xia (2018). Microfluidic formation of coculture tumor spheroids with stromal cells as a novel 3D tumor model for drug testing. ACS Biomaterials Science & Engineering, 4 (12) acsbiomaterials.8b00904, 4425-4433. doi: 10.1021/acsbiomaterials.8b00904 Microfluidic self-assembly of a combinatorial library of single- and dual-ligand liposomes for in vitro and in vivo tumor targeting Ran, Rui, Wang, Haofei, Liu, Yun, Hui, Yue, Sun, Qi, Seth, Arjun, Wibowo, David, Chen, Dong and Zhao, Chun-Xia (2018). Microfluidic self-assembly of a combinatorial library of single- and dual-ligand liposomes for in vitro and in vivo tumor targeting. European Journal of Pharmaceutics and Biopharmaceutics, 130, 1-10. doi: 10.1016/j.ejpb.2018.06.017 Synergetic combinations of dual-targeting ligands for enhanced in vitro and in vivo tumor targeting Liu, Yun, Hui, Yue, Ran, Rui, Yang, Guang-Ze, Wibowo, David, Wang, Hao-Fei, Middelberg, Anton P. J. and Zhao, Chun-Xia (2018). Synergetic combinations of dual-targeting ligands for enhanced in vitro and in vivo tumor targeting. Advanced Healthcare Materials, 7 (15) 1800106, 1800106. doi: 10.1002/adhm.201800106 Understanding the Effects of Nanocapsular Mechanical Property on Passive and Active Tumor Targeting Hui, Yue, Wibowo, David, Liu, Yun, Ran, Rui, Wang, Hao-Fei, Seth, Arjun, Middelberg, Anton P. J. and Zhao, Chun-Xia (2018). Understanding the Effects of Nanocapsular Mechanical Property on Passive and Active Tumor Targeting. ACS Nano, 12 (3), 2846-2857. doi: 10.1021/acsnano.8b00242 Biocompatible amphiphilic hydrogel-solid dimer particles as colloidal surfactants Chen, Dong, Amstad, Esther, Zhao, Chun-Xia, Cai, Liheng, Fan, Jing, Chen, Qiushui, Hai, Mingtan, Koehler, Stephan, Zhang, Huidan, Liang, Fuxin, Yang, Zhenzhong and Weitz, David A (2017). Biocompatible amphiphilic hydrogel-solid dimer particles as colloidal surfactants. ACS Nano, 11 (12), 11978-11985. doi: 10.1021/acsnano.7b03110 Interfacial engineering for silica nanocapsules Wibowo, David, Hui, Yue, Middelberg, Anton P. J. and Zhao, Chun-Xia (2016). Interfacial engineering for silica nanocapsules. Advances in Colloid and Interface Science, 236, 83-100. doi: 10.1016/j.cis.2016.08.001 Emulsion-templated silica nanocapsules formed using bio-inspired silicification Wibowo, David, Zhao, Chun-Xia and Middelberg, Anton P. J. (2014). Emulsion-templated silica nanocapsules formed using bio-inspired silicification. Chemical Communications, 50 (77), 11325-11328. doi: 10.1039/c4cc04904g Multiphase flow microfluidics for the production of single or multiple emulsions for drug delivery Zhao, Chun-Xia (2013). Multiphase flow microfluidics for the production of single or multiple emulsions for drug delivery. Advanced Drug Delivery Reviews, 65 (11-12), 1420-1446. doi: 10.1016/j.addr.2013.05.009 Microfluidic mass-transfer control for the simple formation of complex multiple emulsions Zhao, Chun-Xia and Middelberg, Anton P. J. (2009). Microfluidic mass-transfer control for the simple formation of complex multiple emulsions. Angewandte Chemie-International Edition, 48 (39), 7208-7211. doi: 10.1002/anie.200902485