Kugel, Jennifer - University of Colorado - Chemistry and Biochemistry

个人简介

Ph.D.: school Postdoctoral Fellow: school

研究领域

Molecular Biophysics Proteins & Enzymology Kinetics/Thermochemistry

近期论文

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Walters, R.D., Drullinger, L.F., Kugel, J.F., Goodrich, J.A. (2013). NFATc2 recruits cJun homodimers to an NFAT site to synergistically activate interleukin-2 transcription. Mol Immunol. 56: 48-56 Ponicsan, S.L., Houel, S., Old, W.M., Ahn, N.G., Goodrich, J.A., Kugel, J.F. (2013). The non-coding B2 RNA binds to the DNA cleft and active site region of RNA polymerase II. J. Mol. Biol. Epub ahead of print. Wagner, S.D., Yakovchuk, P., Gilman, B., Poniscan, S.L., Drullinger, L.F., Kugel, J.F., Goodrich, J.A. (2013). Mammalian RNA polymerase II acts as an RNA- dependent RNA polymerase to extend and destabilize a non-coding RNA. EMBO J. Epub ahead of print. Blair, R.H. Goodrich, J.A., and Kugel, J.F. (2012). Single molecule FRET shows uniformity in TBP-induced DNA bending and heterogeneity in bending kinetics. Biochemistry. 51: 7444-7455. Yakovchuk, P., Goodrich, J.A., Kugel, J.F. (2011) B2 RNA represses TFIIH phosphorylation of RNA polymerase II.. Transcription. Jan;2(1):45-49 Nguyen, T.N., Kim, L.J., Walters, R.D., Drullinger, L.F., Lively T.N., Kugel, J.F., and Goodrich, J.A. (2010) The C-terminal region of human NFATc2 binds cJun to synergistically activate interleukin-2 transcription. Mol Immunol. 47(14):2314-22 Yakovchuk, P., Gilman B., Goodrich, J.A., Kugel, J.F. (2010) RNA polymerase II and TAFs undergo a slow isomerization after the polymerase is recruited to promoter-bound TFIID.. J Mol Biol. 397(1):57-68 Wagner, S.D., Kugel, J.F., Goodrich, J.A. (2010) TFIIF facilitates dissociation of RNA polymerase II from noncoding RNAs that lack a repression domain.. Mol Cell Biol.30(1):91-7 Ponicsan S.L., Kugel J.F., and Goodrich J.A., (2010) Genomic gems: SINE RNAs regulate mRNA production Curr Opin Genet Dev(2):149-55 Kugel J.F., and Goodrich J.A.(2010) Dampening DNA binding: a common mechanism of transcriptional repression for both ncRNAs and protein domains RNA Bio(3):305-9 Yakovchuk, P., Goodrich, J.A., Kugel, J.F. (2009) B2 RNA and Alu RNA repress transcription by disrupting contacts between RNA polymerase II and promoter DNA within assembled complexes. Proc Natl Acad Sci U S A. 106(14):5569-74 Goodrich J.A., Kugel J.F,. (2009) From bacteria to humans, chromatin to elongation, and activation to repression: The expanding roles of noncoding RNAs in regulating transcription. Crit Rev Biochem Mol Biol. 44(1):3-15. Walters, R.D., Kugel J.F., and Goodrich J.A., (2009) InvAluable Junk: The Cellular Impact and Function of Alu and B2 RNAs. IUBMB Life(8):831-7 Gilman, B., Drullinger, L.F., Kugel, J.F., Goodrich, J.A. (2009) TATA-binding protein and transcription factor IIB induce transcript slipping during early transcription by RNA polymerase II. J Biol Chem. 284(14):9093-8. Mariner, P.D., Walters, R.D., Espinoza, C.A., Drullinger, L.F., Wagner, S.D., Kugel, J.F., and Goodrich, J.A. (2008). Human Alu RNA Is a Modular Transacting Repressor of mRNA Transcription during Heat Shock. Mol. Cell. 29, 499-509. Wagner, S.D., Goodrich, J.A. and Kugel, J.F. (2008). RNA and the Regulation of Gene Expression; Chapter 9: The Role of Non-Coding RNAs in Controlling Mammalian RNA Polymerase II Transcription. Caister Academic Press. Weaver, J.R., Good, K., Walters, R.D., Kugel, J.F., and Goodrich, J.A. (2007). Characterization of the sequence and architectural constraints of the regulatory and core regions of the human interleukin-2 promoter. Mol. Immunol. 44: 2813-2819. Hieb A.R., Halsey W.A., Betterton M.D., Perkins T.T., Kugel J.F., Goodrich J.A. (2007) TFIIA changes the conformation of the DNA in TBP/TATA complexes and increases their kinetic stability. J Mol Biol. 21;372(3):619-32. Espinoza, C.A., Goodrich, J.A., and Kugel, J.F. (2007). Characterization of the structure, function and mechanism of B2 RNA, an ncRNA repressor of RNA polymerase II transcription. RNA. 13: 583-596. Hieb, A.R., Baran, S., Goodrich, J.A., and Kugel, J.F. (2006). An 8 nt RNA triggers a rate-limiting shift of RNA polymerase II complexes into elongation. EMBO J. 25: 3100-3109. Goodrich, J.A. and Kugel, J.F. (2006). Binding and Kinetics for Molecular Biologists. Cold Spring Harbor Laboratory Press. 182 pages. Computer simulations: http://kinetics.cshl.edu/. Goodrich, J.A. and Kugel, J.F. (2006). Noncoding RNA regulators of RNA polymerase II transcription. Nature Rev. Mol. Cell Biol. 7: 612-616. Weaver, J.R., Kugel, J.F., and Goodrich, J.A. (2005). The sequence at specific positions in the early transcribed region sets the rate of transcript synthesis by RNA polymerase II in vitro. J. Biol. Chem. 280: 39860-39869. Espinoza, C.A., Allen, T.A., Hieb, A.R., Kugel, J.F., and Goodrich, J.A. (2004) B2 RNA binds directly to RNA polymerase II to repress transcript synthesis. Nature Structural and Molecular Biology. 11: 822-829. Allen, T.A., Von Kaenel, S., Goodrich, J.A., and Kugel, J.F. (2004) The SINE encoded mouse B2 RNA represses mRNA transcription in response to heat shock. Nature Structural and Molecular Biology 11: 816-821.