屈明博 - 大连理工大学 - 生物工程学院

个人简介

教育经历 2006.92012.7 大连理工大学生物化工博士 2002.92006.7 大连理工大学生物工程学士 1999.92002.7 辽阳市第一高级中学工作经历 2015.1至今大连理工大学生命学院讲师Associate Professor 2012.62015.1 大连理工大学博士后

研究领域

通过基因组学，转录组学结合蛋白质组学，发现昆虫中参与几丁质代谢的关键蛋白，并通过昆虫生理生化及分子生物学方法研究其生理功能，为农药的开发提供重要的前期理论基础。应用针对几丁质代谢过程的关键基因，一方面设计高活性的dsRNA通过干扰这些基因的表达调控，实现害虫控制；另一方面对关键基因进行重组表达，制备出的大量高活性蛋白通过破坏昆虫几丁质，实现害虫控制

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Qu Mingbo#, Guo Xiaoxi, Tian Suang, Yang Qing*, Kim Myeongjin#, Mun Seulgi, Noh Mi Young, Kramer Karl J., Muthukrishnan Subbaratnam, Yasuyuki Arakane*. AA15 lytic polysaccharide monooxygenase is required for efficient chitinous cuticle turnover during insect molting. Communications Biology, 2022, 5, 518. doi: 10.1038/s42003-022-03469-8.（中科院1区，Top；JCR 1区） 2. Qu Mingbo, Guo Xiaoxi, Kong Lin, Hou Lingjie, Yang Qing*. A midgut-specific lytic polysaccharide monooxygenase of Locusta migratoria is indispensable for the deconstruction of the peritrophic matrix. Insect Science, 2022, doi: 10.1111/1744-7917.13016. SCI: 000780143000001. （中科院1区，Top；JCR 1区） 3. Qu Mingbo, Merzendorfer Hans*, Moussian Bernard*, Yang Qing*. Bioinsecticides as future mainstream pest control agents: opportunities and challenges. Frontiers of Agricultural Science and Engineering, 2022, 9(1): 82‒97. SCI: 000752495700008. 4.Qu Mingbo, Sun Shaopeng, Liu Yuansheng, Deng Xiaorui, Yang Jun, Yang Qing*. Insect group II chitinase OfChtII promotes chitin degradation during larva–pupa molting. Insect Science, 2021, 28(3): 692-704. SCI: 000558850200001. （中科院1区，Top；JCR 1区） 5. Qu Mingbo, Watanabe-Nakayama, Takahiro, Sun Shaopeng, Umeda Kenichi, Guo Xiaoxi, Liu Yuansheng, Ando Toshio, Yang Qing*. High-speed atomic force microscopy reveals factors affecting the processivity of chitinases during interfacial enzymatic hydrolysis of crystalline chitin. ACS catalysis, 2020, 10, 13606−13615. SCI: 000592978900044（中科院1区，Top；JCR 1区） 6. Chen Wei#, Qu Mingbo #, Zhou Yong, Yang Qing*. Structural analysis of group II chitinase (ChtII) catalysis completes the puzzle of chitin hydrolysis in insects. Journal of Biological Chemistry, 2018, 293(8): 2652–2660. SCI: 000426051900003.（中科院Top；Nature index 期刊，JCR 1区） 7. Liu Lin#, Qu Mingbo #, Yang Jun, Yang Qing*. The physiological differentiation along the midgut of Bombyx mori --- inspirations from the proteomics and gene expression patterns of the secreted proteins in the ectoperitrophic space. Insect Molecular Biology, 2018, 27(2): 247-259. SCI: 000426611500011.（JCR 1区） 8. Qu Mingbo, Ren Yuezhou, Liu Yuansheng, Yang Qing*. Studies on the chitin/chitosan binding properties of six cuticular proteins analogous to peritrophin 3 from Bombyx mori. Insect Molecular Biology, 2017, 26: 432–439. SCI: 000404619300007.（JCR 1区） 9. Qu Mingbo #, Ma Li#, Chen Peng, Yang Qing*. Proteomic analysis of insect molting fluid with a focus on enzymes involved in chitin degradation, Journal of Proteome Research, 2014, 13: 2931–2940. SCI: 000337074500021.（JCR 1区） 10. Qu Mingbo, Liu Tian, Chen Peng, Yang, Qing*. A sperm–plasma β-N-Acetyl-D-Hexosaminidase interacting with a chitinolytic β-N-Acetyl-D-Hexosaminidase in insect molting fluid, PLoS ONE, 2013, 8(8): e71738. SCI:000323097300150.（JCR 1区） 11. Qu Mingbo, Yang, Qing*. Physiological significance of alternatively-spliced exon combinations of the single-copy gene OfCHSA in the insect Ostrinia furnacalis (Lepidoptera), Insect Molecular Biology, 2012, 21(4): 395–404. SCI: 000306079300001.（JCR 1区） 12. Qu Mingbo, Yang, Qing*. A novel alternative splicing site of class A chitin synthase from the insect Ostrinia furnacalis --- gene organization, expression pattern and physiological significance, Insect Biochemistry and Molecular Biology, 2011, 41(12): 923–931. SCI: 000297889800001. （中科院1区，Top；JCR 1区）