曹俊杰 - 澳门大学 - 中华医药研究院

个人简介

Academic Qualifications 2018: PhD Graduate Institute of Natural Products, Kao Hsiung Medical University, Kao Hsiung, Taiwan 2013: MSc Department of Biotechnology, Kao Hsiung Medical University, Kao Hsiung, Taiwan

研究领域

(1) Understanding the molecular mechanisms by which ubiquitination contributes to cancer and autoimmune diseases. (2) Discovery and characterization of bioactive compounds from traditional Chinese medicine (TCM) with anticancer and anti-inflammatory effects.

近期论文

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1.Chon-Kit Chou, Xin Chen*. “Preferential Expansion of CD4+Foxp3+ Regulatory T Cells (Tregs) In Vitro by Tumor Necrosis Factor” Methods in Molecular Biology (Accepted). 2.Chon-Kit Chou, Hurng-Wern Huang, Chun-Feng Yang, Hans-Uwe Dahms, Shih-Shin Liang, Tsu-Nai Wang, Po-Lin Kuo, Edward Hsi, Eing-Mei Tsai*, Chien-Chih Chiu*. “Reduced camptothecin sensitivity of estrogen receptor-positive human breast cancer cells following exposure to di(2-ethylhexyl)phthalate (DEHP) is associated with DNA methylation changes” Environmental Toxicology. 2019 Feb 5; 34(4):401-414. 3.Chon-Kit Chou, Wangta Liu, Yu-Jie Hong, Hans-Uwe Dahms, Chen-Hao Chiu, Wen-Tsan Chang, Ching-Ming Chien, Chia-Hung Yen, Yuan-Bin Cheng*, Chien-Chih Chiu*. “Ethyl acetate extract of Scindapsus hederaceus exerts the inhibitory bioactivity on human non-small cell lung cancer cells through modulating ER stress” International Journal of Molecular Sciences. 2018 Jun 21; 19(7):1832. 4.Chon-Kit Chou, Ya-Ting Yang, Ho-Chun Yang, Shih-Shin Liang, Tsu-Nai Wang, Po-Lin Kuo, Hui-Min David Wang, Eing-Mei Tsai*, Chien-Chih Chiu*. “The Impact of Di(2-ethylhexyl)phthalate on Cancer Progression” Archivum Immunologiae et Therapiae Experimentalis. 2017 Dec 5; 66(3):183-197. 5.Chon-Kit Chou, Chin-Ju Tang, Han-Lin Chou, Chun-Yen Liu, Ming-Chong Ng, Yu-Ting Chang, Shyng-Shiou F. Yuan, Eing-Mei Tsai, Chien-Chih Chiu*. “The Potential Role of Krüppel-Like Zinc-Finger Protein Glis3 in Genetic Diseases and Cancers” Archivum Immunologiae et Therapiae Experimentalis. 2017 May 18; 65(5):381-389. 6.Chon-Kit Chou, Yu-Ting Chang , Michal Korinek, Yei-Tsung Chen, Ya-Ting Yang, Steve Leu, I-Ling Lin, Chin-Ju Tang, Chien-Chih Chiu*. “The Regulations of Deubiquitinase USP15 and Its Pathophysiological Mechanisms in Diseases” International Journal of Molecular Sciences. 2017 Feb 24; 18(3):483. 7.Chou-Kit Chou, Chang-Yi Wu, Jeff Yi-Fu Chen, Ming-Chong Ng, Hui-Min David Wang, Jen-Hao Chen, Shyng-Shiou F. Yuan, Eing-Mei Tsai, Jan-Gowth Chang, Chien-Chih Chiu*. “BubR1 Acts as a Promoter in Cellular Motility of Human Oral Squamous Cancer Cells through Regulating MMP-2 and MMP-9” International Journal of Molecular Sciences. 2015 Jul 3; 16(7):15104-15117. Co-authored Publications 1.Ruixin Li, Shaokui Chen, Yibo Chen, Chon-Kit Chou, Xin Chen*. “Scutellarin inhibits TNF-induced proliferative expansion of tumor associated TNFR2-expressing CD4+Foxp3+ regulatory T cells” Cancer Letters (under review). 2.Sheng-Kai Hsu, Chien-Chih Chiu, Hans-Uwe Dahms, Chon-Kit Chou, Chih-Mei Chen, Wen-Tsan Chang, Kai-Chun Cheng, Hui-Min David Wang, I-Ling Lin*. “Unfolded Protein Response (UPR) in Survival, Dormancy, Immunosuppression, Metastasis, and Treatments of Cancer Cells” International Journal of Molecular Sciences.2019 May 22, 20(10), 2518. 3.Yen-Chung Huang, Jebiti Haribabu, Ching-Ming Chien, Gopal Sabapathi, Chon-Kit Chou, Ramasamy Karvembu, Ponnambalam Venuvanalingam, Wei-Min Ching, Ming-Li Tsai, Sodio C.N. Hsu*. “Half-sandwich Ru(η6-p-cymene) complexes featuring pyrazole appended ligands: Synthesis, DNA binding and in vitro cytotoxicity” Journal of Inorganic Biochemistry. 2019 May; 194: 74-84. 4.Ching-Ming Chien, Juan-Cheng Yang, Pin-Hsuan Wu, Chang-Yi Wu, Guan-Yu Chen, Yang-Chang Wu, Chon-Kit Chou, Chih-Hua Tseng, Yeh-Long Chen, Li-Fang Wang*, Chien-Chih Chiu*. “Phytochemical naphtho[1,2-b] furan-4,5_x001e_dione induced topoisomerase IImediated DNA damage response in human non-small-cell lung cancer” Phytomedicine. 2019 June 15; 54:109-119. 5.Wen-Tsan Chang, Wangta Liu, Yi-Han Chiu, Bing-Hung Chen, Shih-Chang Chuang, Yen-Chun Chen, Yun-Tzh Hsu, Mei-Jei Lu, Shean-Jaw Chiou, Chon-Kit Chou and Chien-Chih Chiu*. “A 4-Phenoxyphenol Derivative Exerts Inhibitory Effects on Human Hepatocellular Carcinoma Cells through Regulating Autophagy and Apoptosis Accompanied by Downregulating α-Tubulin Expression” Molecules. 2017 May 21; 22(5). 6.Michal Korinek, Kuan-Ming Chen, Yu-Han Jiang,Mohamed El-Shazly, Joel Stocker, Chon-Kit Chou, Tsong-Long Hwang, Yang-Chang Wu, Bing-Hung Chen*, Fang-Rong Chang*. “Anti-allergic potential of Typhonium blumei: Inhibition of degranulation via suppression of PI3K/PLCγ2 phosphorylation and calcium influx” Phytomedicine. 2016 Dec 15; 23(14):1706-1715. 7.Hueiwang Anna Jeng*, Chih-Hong Pan, Mu-Rong Chao, Chien-Chih Chiu, Guodong Zhou, Chon-Kit Chou, Wen-Yi Lin. “Sperm quality and DNA integrity of coke oven workers exposed to polycyclic aromatic hydrocarbons” Int J Occup Med Environ Health. 2016 Nov 18; 29(6):915-926. 8.Wen-Tsan Chang,Yao Fong, Shih-Chang Chuang, Chon-Kit Chou, Han-Lin Chou, Chun-Feng Yang, Chih-Hua Tseng, Yeh-Long Chen, Chien-Chih Chiu*. “9-bis[2-(pyrrolidin-1-yl)ethoxy]-6-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-11H-indeno[1,2-c]quinolin-11-one (BPIQ), a quinoline derivative inhibits human hepatocellular carcinoma cells by inducing ER stress and apoptosis” Anticancer Agents Med Chem. 2016 Aug 2;17(5): 692-700. 9.Chih-Hua Tseng,You-Ren Chen, Cherng-Chyi Tzeng, Wangta Liu, Chon-Kit Chou, Chien-Chih Chiu*, Yeh-Long Chen*. “Discovery of indeno[1,2-b]quinoxaline derivatives as potential anticancer agents” Eur J Med Chem. 2016 Jan 27; 108:258-73. 10.Chih-Hua Tseng,Cherng-Chyi Tzeng, Chien-Chih Chiu, Chih-Yao Hsu, Chon-Kit Chou, Yeh-Long Chen*. “Discovery of 2-[2-(5-nitrofuran-2-yl)vinyl]quinoline derivatives as a novel type of antimetastatic agents” Bioorg Med Chem. 2015 Jan 1; 23(1):141-8. 11.Ching-Yu Yen, Shih-Shin Liang, Lo-Yi Han, Han-Lin Chou, Chon-Kit Chou,Shinne-Ren Lin, and Chien-Chih Chiu*. “Cardiotoxin III inhibits proliferation and migration of oral cancer cells through MAPK and MMP signaling” 2013 Apr 8; 2013:650946. 12.Chien-Chih Chiu, Jo-Wen Haung, Fang-Rong Chang, Kuang-Jing Huang, Hsuan-Min Huang, Hurng-Wern Huang, Chon-Kit Chou, Yang-Chang Wu*, Hsueh-Wei Chang*. “Golden Berry-Derived 4β-hydroxywithanolide E for Selectively Killing Oral Cancer Cells by Generating ROS, DNA Damage, and Apoptotic Pathways” PLoS One. 2013 May 21; 8(5):e64739. 13.Chien-Chih Chiu,Po-Len Liu, Kuang-Jing Huang, Hui-Min Wang, Kuo-Feng Chang, Chon-Kit Chou, Fang-Rong Chang, Inn-Wen Chong, Kang Fang, Jia-Shing Chen, Hsueh-Wei Chang*, and Yang-Chang Wu*. “Goniothalamin inhibits growth of human lung cancer cells through DNA damage, apoptosis, and reduced migration ability” J Agric Food Chem. 2011 Apr 27; 59(8):4288-93.