个人简介

Education PhD Pathological Sciences, Department of Chemical Pathology, Chinese University of Hong Kong, Hong Kong (1996) MSc Bioinformatics, University of Manchester, United Kingdom (2005) BSc Biochemistry, Chinese University of Hong Kong, Hong Kong (1993) Academic and Professional Experience 2014-present Associate Professor, Faculty of Health Sciences, University of MacauDirector of Proteomics Core, Director of Pilot Laboratory 2010.9-2014.8 Associate Professor (tenured), Department of Paediatrics, Faculty of Medicine, Chinese University of Hong Kong 2008.9-2010.8 Associate Professor (tenured), Department of Medicine and Therapeutics, Faculty of Medicine, Chinese University of Hong Kong 2004.9-2008.8 Assistant Professor, Department of Medicine and Therapeutics, Faculty of Medicine, Chinese University of Hong Kong 2002.9-2004.8 Assistant Professor, Department of Clinical Oncology, Faculty of Medicine, Chinese University of Hong Kong 1996.10-2002.8 Postdoctoral fellow, Department of Clinical Oncology, Department of Chemical Pathology, Faculty of Medicine, Chinese University of Hong Kong Course Outlines HSCI3003 Biostatistics and Experimental Design HSCI7004 Healthcare Analytics

研究领域

Applications of proteomics, glycoproteomics, glycomics and metabolomics to biomarker discovery for disease diagnoses and prognoses; Development of high-throughput mass spectrometry technologies for proteomics, glycoproteomics, glycomics and metabolomics studies; Applications of bioinformatics to data mining, discovery of biomarkers, disease outcome prediction and understanding of carcinogenesis; Deciphering human proteome (Human Proteome Projects) Deciphering functional roles of alpha-fetoprotein

In Capacity of Co-Investigator (12 competitive grants, total of MOP$24 million): Revealing roles of the CAMSAP1L1 gene in symptomatic epilepsy. General Research Fund (GRF), Hong Kong Research Grant Council, Project code: CUHK 460313, 2013-2015. Amount: HK$692,826 Interaction of influenza A virus nucleoproteins with the C-terminal region of RNA polymerase PB2 subunit. General Research Fund (GRF), Hong Kong Research Grant Council, Project code: 473111. 2012-2015. Amount: HK$ 1,546,000 Centre for MicroRNA Study – Basic Research and Clinical Potentials in Cancer, CUHK8/CRF/11R, 2011-2014, HK$4,253,000 Centre for MicroRNA Study – Basic Research and Clinical Potentials in Cancer, CUHK4/CRF/08, 2008-2011. Amount: HK$5.7M Role of Small Non-Coding miR-221 and miR-222 in the Oncogenesis of Human Hepatocellular Carcinoma, General Research Fund (GRF), Hong Kong Research Grant Council, 2007-2009. Amount: HK$645,500 Proteomic Profiling of Liver Fibrosis in Chronic Hepatitis B. Earmarked Grant, Hong Kong Research Grant Council, 2005-2007. Amount: HK$718,957 Function Characterization of PFKT1 in the Cellular Invasion of Hepatocellular Carcinoma. Earmarked Grant, Hong Kong Research Grant Council, 2006-2008. Amount: HK$1,289,914 Research Into Integrative Medical Sciences. Li Ka Shing Institute of Health Sciences Grant. 2005-2008. Project code 6901955. HK$2,500,000 Hepatocellular Carcinoma Research Group: Clinical Applications of Functional Genomics. Central Allocation Grant, Research Grant Council, 2003/2006. Amount: HK$4,000,000 Studies on Markers of Tumor Hypoxia in Nasopharyngeal Carcinoma. Hong Kong Research Grant Council, CUHK 4093/02M, 2002/2004. Amount: HK$ 1,240,000 Tumor Markers for Prediction of Treatment Response to Gemcitabine-Based Regimens: A Search by Quantitative Proteomics. Eli Lilly. Gemzar Grant Award, 2002/2003. Amount: US$50,000 Studies on Anti-tumour Effect of M225, a Monoclonal Anti-epidermal Growth Factor Receptor Antibody, on Nasopharyngeal Carcinoma. Hong Kong Research Grant Council, CUHK 4039/01M, 2001/2003. Amount: HK$699,600

近期论文

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Representative Publications Hon KL.; Tsang YC.; Poon TCW.; Pong NH.; Luk NM.; Leung TN.; Chow CM.; Leung TF. Dairy and nondairy beverage consumption for childhood atopic eczema: what health advice to give? Clinical and experimental dermatology 2016;41(2):129-37. He M.; Qin H.; Poon TCW.; Sze SC.; Ding X.; Co NN.; Ngai SM.; Chan TF.; Wong N. Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs. Carcinogenesis 2015; bgv; 081. Chaiyarit S, Singhto N, Chen YJ, Cheng CY, Chiangjong W, Kanlaya R, Lam HH, Peerapen P, Sung TY, Tipthara P, Pandey A, Poon TCW, Chen YJ, Sirdeshmukh R, Chung MC, Thongboonkerd V. Chromosome-centric Human Proteome Project (C-HPP): Chromosome 12. Journal of Proteome Research. 13(7):3160-5, 2014. Ng EWY, Wong MYM, Poon TCW*. Advances in MALDI mass spectrometry in clinical diagnostic applications. Topics in Current Chemistry 336:139-75, 2014. [Review] Ng EWY, Poon TCW, Lam HS, Cheung HM, Ma TPY, Chan KYY, Wong RPO, Leung KT, Lam MMT, Li K, Ng PC. Gut Associated Biomarkers L-FABP, I-FABP, TFF3 and LIT score for Diagnosis of Surgical Necrotizing Enterocolitis in Preterm Infants. Annals of Surgery 258(6):1111-8, 2013. Ng PC, Ang IL, Chiu RW, Li K, Lam HS, Wong RPO, Chui KM, Cheung HM, Ng EWY, Sung JJY, Lo YMD, Poon TCW*. Host-response biomarkers for accurate, early diagnosis of septicemia and necrotizing enterocolitis in preterm Infants. Journal of Clinical Investigation 120:2989-3000, 2010. Kam RKT, Poon TCW*, Chan HLY, Wong N, Hui AY, Sung JJY. High-throughput quantitative profiling of serum N-glycome by MALDI-TOF mass spectrometry and N-glycomic fingerprint of liver fibrosis. Clinical Chemistry 53: 1254-63, 2007. Poon TCW*, Wong N, Lai PBS, Rattray M, Johnson PJ, Sung JJY. A Tumor progression model for hepatocellular carcinoma – Bioinformatic analysis of genomic data. Gastroenterology 131: 1262-1270, 2006. [Editorial by Thorgeirsson S.S. in Gastroenterology 131:1344-6, 2006.] Poon TCW, Sung JJY, Chow SM, Ng EKW, Yu ACW, Chu ESH, Hui AAY, Leung WK. Diagnosis of gastric cancer by serum proteomic fingerprinting. Gastroenterology 130: 1858-1864, 2006 [Editorial by Kawada N. in Gastroenterology 130:1917-9, 2006] Ang IL, Poon TCW*, Lai PBS, Chan ATC, Ngai SM, Hui AY, Johnson PJ, Sung JJY. Study of serum haptoglobin and its glycoforms in the diagnosis of hepatocellular carcinoma – a glycoproteomic approach. Journal of Proteome Research 5: 2691-2700, 2006. Poon TCW*, Hui AY, Chan HLY, Ang IL, Chow SM, Wong N, Sung JJY. Prediction of liver fibrosis and cirrhosis in chronic hepatitis B infection by serum proteomic fingerprinting: a pilot study. Clinical Chemistry 51: 328-335, 2005. Poon TCW*, Chan KCA, Ng PC, Chiu RWK, Ang IL, Tong YK, Ng EKO, Cheng FWT, Li AM, Hon EKL, Fok TF, Lo YMD. Serial Analysis of Plasma Proteomic Signatures in Pediatric Patients with Severe Acute Respiratory Syndrome and Correlation with Viral Load. Clinical Chemistry 50: 1452-1455. 2004. Poon TCW, Yip TT, Chan ATC, Yip C, Yip V, Mok TSK, Leung TWT, Ho S, Johnson PJ. Comprehensive proteomic profiling identifies serum proteomic signatures for detection of hepatocellular carcinoma and its subtypes. Clinical Chemistry 49: 752-760, 2003. Poon TCW, Mok TSK, Chan ATC, Chan CML, Leung V, Tsui STH, Leung TWT, Wong HTM, Ho SKW, Johnson PJ. Quantification and utility of monosialylated alpha-fetoprotein in the diagnosis of hepatocellular carcinoma with nondiagnostic serum total a-fetoprotein. Clinical Chemistry 48: 1021 –1027. 2002. Poon TCW, Chan ATC, Zee B, Ho SKW, Mok TSK, Leung TWT, Johnson PJ. Application of classification tree and neural network algorithm to the identification of serological liver marker profiles in the diagnosis of hepatocellular carcinoma. Oncology 61: 275-283. 2001 Poon TCW, Johnson PJ. Proteome analysis and its impact on the discovery of serological tumor markers. Clinica Chimica Acta 313: 231-239. 2001. [Review] Johnson PJ, Poon TCW, Hjelm NM, Ho CS, Blake C, Ho SKW. Structures of disease-specific serum alpha-fetoprotein. British Journal of Cancer 83: 1330-1337. 2000.

学术兼职

Editorial Board of “Scientific Reports” (Nature Publisher) (since 2014) Editorial Board of “Clinical Proteomics” (since 2014) Editorial Board of “PROTEOMICS – Clinical Applications” (since 2007) Editorial Board of “ Journal of Bioinformatics and Proteomics” (since 2009) Guest Editor of “ BioMed Research International” (2013) Guest Editor of “Topics in Current Chemistry” (2012) Council member, Human Proteome Organization (since 2007) Secretary General, Asia and Oceania Human Proteome Organization (since 2014) Council member, Asia and Oceania Human Proteome Organization (since 2007) Hong Kong Representative, International Mass Spectrometry Foundation (2010-2014) Treasurer, Hong Kong Proteomics Society (since 2011) Vice-President, Hong Kong Proteomics Society (2006-2011) President, Hong Kong Society of Mass Spectrometry (2010-2014) Vice-President, Hong Kong Society of Mass Spectrometry (2008-2010) Council member, Hong Kong Society of Mass Spectrometry (since 2004) Panel member, Physical Science Panel, Research Grant Committee, The University Grants Committee, Hong Kong (2012 – 2015) Grant Review Board member, Health and Medical Research Fund, Food and Health Bureau, Hong Kong (2012 – 2014) Grant Review Board member, Research Fund for the Control of Infectious Diseases, Food and Health Bureau, Hong Kong (2011 – 2012) Member, Planning Committee, Research Laboratory, Hong Kong Children Hospital, Food and Health Bureau, Hong Kong (2010 – 2014)