个人简介

Education Knowledge Transfer Partnership (KTP) Postdoctoral Fellow Queen’s University Belfast, UK (2004-2007) PhD in Biomedical Sciences University of Ulster, UK (2003) BSc (1st Class Hons) in Biotechnology University of Ulster, UK (2000) NVQ Level 4 (Higher National Diploma) in Management Chartered Management Institute, UK (2007) Academic and Professional Experience 2018-Present Associate Professor, Faculty of Health Sciences, University of Macau 2013-present Visiting Scientist, Cancer Research UK Cambridge Institute, University of Cambridge, UK 2014-2018 Assistant Professor, Faculty of Health Sciences, University of Macau 2007-2017 Visiting Research Fellow, School of Pharmacy, Queen’s University Belfast, UK 2011-2014 Senior Research Associate / Fellow, Department of Oncology / Cancer Research UK Cambridge Institute, University of Cambridge, UK 2007-2011 Senior Scientist, Fusion Antibodies Ltd., UK Ad Hoc Invited External Examiner: School of Pharmacy, Queen’s University Belfast, UK — PhD programme and MPhil programme Li Ka Shing Faculty of Medicine, University of Hong Kong — MMedSc programme Faculty of Medicine, Nursing & Health Sciences, Monash University, Australia — PhD programme School of Biomedical Sciences, Chinese University of Hong Kong – PhD programme Course Outlines HSCI1003 General and Clinical Biochemistry HSCI4009 Toxicology

研究领域

Prof. Kwok’s research interests mainly focus on the development of novel monoclonal antibodies and natural biomolecules (including venom-based peptides, plant-derived molecules etc.) as prototype drugs for anticancer and anti-inflammatory therapies. In addition, Prof. Kwok’s research group also expands their research and scientific knowledge in the areas of existing and novel cancer biomarkers such as 1) matricellular protein — OPN, 2) metalloproteinase — ADAM17, ADAMTS5 and ADAMTS8, 3) DNA replication licensing factor — MCM proteins, 4) small GTP binding protein — RAN and RCC1, as well as immunotherapy markers (e.g. PD-1/PD-L1) in order to identify and validate their prognostic and therapeutic values according to the roles in hallmarks of cancer and chronic diseases.

Patents 1. Kwok H. F., Rui M., Chen G. (2020) A venom-based peptide and its application. Patent CN 202010469590.8 2. Kwok H. F., Xie R. (2020) Use of anti-tumour effects of a’human & mouse cross-reactive’anti-adam17 antibody in treating pancreatic cancer. Patent US 20190375848A1 3. Kwok H. F. (2019) Method of Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin II. Patent US 20190015505A1 4. Olwill S. A., Kwok H. F., Johnston J. A., Whelan C., Clarke J., Shuralev E. (2010) Diagnostic methods and kits – The identification of tuberculosis infection in animals such as badgers, cervids and wild boar. Patent WO 2010097625 5. Olwill S. A., Buick R., Kwok H. F., Scott C., Ward C. (2010) Antibody Therapy – Described are methods of inhibiting angiogenesis, the methods comprising the simultaneous, sequential or separate administration of (i) an anti- Cathepsin S antibody molecule, and (ii) an anti-VEGF antibody molecule. Also described are anti-Cathepsin S humanized antibodies, pharmaceutical compositions and methods of treatment using such antibodies. Patent WO 2010094981 6. Olwill S. A., Johnston J. A., Kwok H. F., Whelan C, Clarke J. (2009) Diagnostic method and kit – The invention relates to methods for diagnosis of tuberculosis comprising determining the presence or absence of, or an immune response to a group of antigens. Patent WO2009024822 7. Olwill S. A., Buick R. J., Kwok H. F., Johnston J. A. (2006) Assays for diagnosis of tuberculosis and uses thereof – The identification of mycobacterial antigens which are highly immunogenic and which may be used in assays and methods for the diagnosis of tuberculosis. Patent WO2006117538

近期论文

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Journal Articles: Guo, L., Wei, R., Lin, Y., Kwok, H. F. (2020) Clinical and Recent Patents Applications of PD-1/PD-L1 Targeting Immunotherapy in Cancer Treatment — Current Progress, Strategy and Future Perspective. Frontiers in Immunology (In Press) Li, J. N., and Kwok, H. F. (2020) Current Strategies for Treating NSCLC: From Biological Mechanisms to Clinical Treatment. Cancers (Basel) 12 (6), E1587 Ma, R., Ren, Z. L., Li, B., Siu, S. W. I., Chen, G. K., and Kwok, H. F. (2020) Novel Venom-Based Peptides (P13 and its Derivative-M6) to Maintain Self-Renewal of Human Embryonic Stem Cells by Activating FGF and TGFbeta Signaling Pathways. Stem Cell Res Ther 11 (1), 243 Yeung, L., Anderson, J. M. L., Wee, J. L., Demaria, M. C., Finsterbusch, M., Liu, Y. S., Hall, P., Smith, B. C., Dankers, W., Elgass, K. D., Wicks, I. P., Kwok, H. F., Wright, M. D., and Hickey, M. J. (2020) Leukocyte Tetraspanin CD53 Restrains Alpha3 Integrin Mobilization and Facilitates Cytoskeletal Remodeling and Transmigration in Mice. J Immunol 205 Ma, R., Wong, S. W., Ge, L., Shaw, C., Siu, S. W. I., and Kwok, H. F. (2020) In Vitro and MD Simulation Study to Explore Physicochemical Parameters for Antibacterial Peptide to Become Potent Anticancer Peptide. Mol Ther Oncolytics 16, 7-19 Yang, Z., Chan, K. I., Kwok, H. F., and Tam, K. Y. (2019) Novel Therapeutic Anti-ADAM17 Antibody A9(B8) Enhances EGFR-Tki-Mediated Anticancer Activity in NSCLC. Transl Oncol 12 (11), 1516-1524 Li, B., Lyu, P., Xie, S. P., Qin, H. X., Pu, W. Y., Xu, H. X., Chen, T., Shaw, C., Ge, L. L., and Kwok, H. F. (2019) Lfb: A Novel Antimicrobial Brevinin-Like Peptide from the Skin Secretion of the Fujian Large Headed Frog, Limnonectes Fujianensi. Biomolecules 9 (6), E242 Ge, L. L., Li, B., Xu, H. X., Pu, W. Y., and Kwok, H. F. (2019) Backfilling Rolling Cycle Amplification with Enzyme-DNA Conjugates on Antibody for Portable Electrochemical Immunoassay with Glucometer Readout. Biosensors and Bioelectronics 132, 210-216 Chen, P. C., Wang, Q. S., Xie, J. W., and Kwok, H. F. (2019) Signaling Networks and the Feasibility of Computational Analysis in Gastroenteropancreatic Neuroendocrine Tumors. Semin Cancer Biol 58, 80-89 Wei, R., Wong, J. P. C., Lyu, P., Xi, X. P., Tong, O., Zhang, S. D., Yuen, H. F., Shirasawa, S., and Kwok, H. F. (2018) In Vitro and Clinical Data Analysis of Osteopontin as a Prognostic Indicator in Colorectal Cancer. J Cell Mol Med 22 (9), 4097-4105 Rajendran, B. K., Xavier Suresh, M., Bhaskaran, S. P., Harshitha, Y., Gaur, U., and Kwok, H. F. (2018) Pharmacoinformatic Approach to Explore the Antidote Potential of Phytochemicals on Bungarotoxin from Indian Krait, Bungarus Caeruleus. Computational and Structural Biotechnology Journal 16, 450-461 Mughal, M. J., Mahadevappa, R., and Kwok, H. F. (2018) DNA Replication Licensing Proteins: Saints and Sinners in Cancer. Semin Cancer Biol 58, 11-21 Mahadevappa, R., Neves, H., Yuen, S. M., Jameel, M., Bai, Y. C., Yuen, H. F., Zhang, S. D., Zhu, Y. Z., Lin, Y., and Kwok, H. F. (2018) DNA Replication Licensing Protein MCM10 Promotes Tumor Progression and Is a Novel Prognostic Biomarker and Potential Therapeutic Target in Breast Cancer. Cancers (Basel) 10 (9), E282 Li, B., Lyu, P., Xi, X. P., Ge, L. L., Mahadevappa, R., Shaw, C., and Kwok, H. F. (2018) Triggering of Cancer Cell Cycle Arrest by a Novel Scorpion Venom-Derived Peptide-Gonearrestide. J Cell Mol Med 22 (9), 4460-4473 Huang, Y. D., Zhang, Y. F., Ge, L. L., Lin, Y., and Kwok, H. F. (2018) The Roles of Protein Tyrosine Phosphatases in Hepatocellular Carcinoma. Cancers (Basel) 10 (3), E82 Ye, J., Yuen, S. M., Murphy, G., Xie, R. Y., and Kwok, H. F. (2017) Anti-Tumor Effects of a ‘Human & Mouse Cross-Reactive’ Anti-ADAM17 Antibody in a Pancreatic Cancer Model in Vivo. Eur J Pharm Sci 110, 62-69 Wong, J., Wei, R., Lyu, P., Tong, O., Zhang, S. D., Wen, Q., Yuen, H. F., El-Tanani, M., and Kwok, H. F. (2017) Clinical and in Vitro Analysis of Osteopontin as a Prognostic Indicator and Unveil Its Potential Downstream Targets in Bladder Cancer. Int J Biol Sci 13 (11), 1373 Wei, R., Wong, J. P. C., and Kwok, H. F. (2017) Osteopontin — a Promising Biomarker for Cancer Therapy. J Cancer 8 (12), 2173-2183 Wang, Q. S., Lin, W., Tang, X. Q., Li, S. H., Guo, L. B., Lin, Y., and Kwok, H. F. (2017) The Roles of Micrornas in Regulating the Expression of PD-1/PD-L1 Immune Checkpoint. Int J Mol Sci 18 (12), 2540 Neves, H., and Kwok, H. F. (2017) In Sickness and in Health: The Many Roles of the Minichromosome Maintenance Proteins. Biochim Biophys Acta 1868 (1), 295-308 Mahadevappa, R., Ma, R., and Kwok, H. F. (2017) Venom Peptides: Improving Specificity in Cancer Therapy. Trends Cancer 3 (9), 611-614 Kawai, T., Takayanagi, T., Forrester, S., Preston, K., Obama, T., Tsuji, T., Kobayashi, T., Boyer, M., Cooper, H., Kwok, H. F., Hashimoto, T., Scalia, R., Rizzo, V., and Eguchi, S. (2017) Vascular ADAM17 (a Disintegrin and Metalloproteinase Domain 17) Is Required for Angiotensin II/Β-Aminopropionitrile–Induced Abdominal Aortic Aneurysm. Hypertension, HYPERTENSIONAHA. 117.09822 Takayanagi, T., Forrester, S., Kawai, T., Obama, T., Tsuji, T., Elliott, K., Nuti, E., Rossello, A., Kwok, H. F., Scalia, R., Rizzo, V., and Eguchi, S. (2016) Vascular ADAM17 as a Novel Therapeutic Target in Mediating Cardiovascular Hypertrophy and Perivascular Fibrosis Induced by Angiotensin Iinovelty and Significance. Hypertension 68 (4), 949-955 Kwok, H. F., Zhang, S. D., McCrudden, C., Yuen, H. F., Ting, K. P., Wen, Q., Khoo, U. S., and Chan, K. Y. K. (2015) Prognostic Significance of Minichromosome Maintenance Proteins in Breast Cancer. Am J Cancer Res 5 (1), 52-71 Kwok, H. F., Botkjaer, K., Tape, C., Huang, Y. C., McCafferty, J., and Murphy, G. (2014) Development of a ‘Mouse and Human Cross-Reactive’affinity-Matured Exosite Inhibitory Human Antibody Specific to TACE (ADAM17) for Cancer Immunotherapy. Protein Eng Des Sel 27 (6), 179-190 Kwok, H. F., Buick, R. J., Kuehn, D., Gormley, J. A., Doherty, D., Jaquin, T. J., McClurg, A., Ward, C., Byrne, T., Jaworski, J., Leung, K. L., Snoddy, P., McAnally, C., Burden, R. E., Gray, B., Lowry, J., Sermadiras, I., Gruszka, N., Courtenay-Luck, N., Kissenpfennig, A., Scott, C. J., Johnston, J. A., and Olwill, S. A. (2011) Antibody Targeting of Cathepsin S Induces Antibody-Dependent Cellular Cytotoxicity. Mol Cancer 10, 147 Fry, B. G., Winter, K., Norman, J. A., Roelants, K., Nabuurs, R. J., van Osch, M. J., Teeuwisse, W. M., van der Weerd, L., McNaughtan, J. E., Kwok, H. F., Scheib, H., Greisman, L., Kochva, E., Miller, L. J., Gao, F., Karas, J., Scanlon, D., Lin, F., Kuruppu, S., Shaw, C., Wong, L., and Hodgson, W. C. (2010) Functional and Structural Diversification of the Anguimorpha Lizard Venom System. Mol Cell Proteomics 9 (11), 2369-2390 Fry, B. G., Roelants, K., Winter, K., Hodgson, W. C., Griesman, L., Kwok, H. F., Scanlon, D., Karas, J., Shaw, C., Wong, L., and Norman, J. A. (2010) Novel Venom Proteins Produced by Differential Domain-Expression Strategies in Beaded Lizards and Gila Monsters (Genus Heloderma). Mol Biol Evol 27 (2), 395-407 Fry, B. G., Wroe, S., Teeuwisse, W., van Osch, M. J., Moreno, K., Ingle, J., McHenry, C., Ferrara, T., Clausen, P., Scheib, H., Winter, K. L., Greisman, L., Roelants, K., van der Weerd, L., Clemente, C. J., Giannakis, E., Hodgson, W. C., Luz, S., Martelli, P., Krishnasamy, K., Kochva, E., Kwok, H. F., Scanlon, D., Karas, J., Citron, D. M., Goldstein, E. J., McNaughtan, J. E., and Norman, J. A. (2009) A Central Role for Venom in Predation by Varanus Komodoensis (Komodo Dragon) and the Extinct Giant Varanus (Megalania) Priscus. Proc Natl Acad Sci U S A 106 (22), 8969-8974 Kwok, H. F., Chen, T., O’Rourke, M., Ivanyi, C., Hirst, D., and Shaw, C. (2008) Helokinestatin: A New Bradykinin B2 Receptor Antagonist Decapeptide from Lizard Venom. Peptides 29 (1), 65-72 Books / Book Chapters: Kwok, H. F. (Ed.)* (2019) Venom Toxins as Potential Targeted Therapy (pp. 1-167). Basel, Switzerland: Multidisciplinary Digital Publishing Institute (MDPI). Fry, B. G., Roelants, K., Jackson, T. N. W., Takacs, Z., Reeks, T. and Kwok, H. F. (2015) Chapter 18 B-Type natriuretic peptides. In Bryan Fry (Ed.), Venomous Reptiles and Their Toxins (pp. 312-317). Oxford, UK: Oxford University Press. Fry, B. G., Roelants, K., Jackson, T. N. W., Takacs, Z., Reeks, T. and Kwok, H. F. (2015) Chapter 11 Exendin peptides. In Bryan Fry (Ed.), Venomous Reptiles and Their Toxins (pp. 247-254). Oxford, UK: Oxford University Press.

学术兼职

Ad Hoc Invited Reviewer of Journals / Book / Grants: Applied Biochemistry and Biotechnology Analytical Cellular Pathology Biology BMC Cancer BMC Urology BMC Molecular Biology Breast Cancer Targets and Therapy Biochemical Pharmacology Biomedicine & Pharmacotherapy Biofactors Biomarkers in Medicine Cells Cell Death and Disease Cancers Cancer Biomarkers Cancer Biology & Medicine Cancer Management & Research Cancer Medicine Cancer Informatics Cellular and Molecular Life Sciences Cell Biology International Cellular Physiology and Biochemistry Computational & Structural Biotechnology Journal Communications Biology Current Pharmaceutical Biotechnology Current Drug Targets Current Protein & Peptide Science Current Enzyme Inhibition Cancer Biology & Treatment Drug Design, Development and Therapy Experimental and Therapeutic Medicine Future Oncology Immunology Letters IUBMB Life International Journal of Biological Sciences International Journal of Biochemistry Research & Review International Journal of Nanomedicine International Journal of Oncology International Immunopharmacology Journal of Cancer Metastasis and Treatment Journal of Cell Science & Therapy Journal of Cellular and Molecular Medicine Journal of Experimental & Clinical Cancer Research Journal of Cancer Journal of Molecular Evolution Journal of Ovarian Research Journal of Pain Research Journal of Thoracic Disease Journal of Venom Research Langenbeck’s Archives of Surgery mAbs Microbial Pathogenesis Medical Science Monitor Molecular Biotechnology Molecular Biology Reports Molecular Medicine Reports Molecular Therapy – Oncolytics Molecular Pain Molecules Mutation Research Oncogene OncoTargets & Therapy Oncology Reports Oncology Letters PeerJ PLoS One PNAS Peptides Pharmacology & Therapeutics Regulatory Peptide Research in Veterinary Science Seminars in Cancer Biology Scientific Reports Toxicology in Vitro Toxins Toxicon Theranostics Book — Bioactive Natural Products – Elsevier, Amsterdam Book — Peptides in Molecular Pharmaceutics: Targeted Therapy and Drug Delivery – Nature Springer Grant — Breast Cancer Now 2017, UK Grant — Tyrolean Science Fund 2014/2015, Austria Grant — The Wellcome Trust/DBT India Alliance Fellowship 2019, UK/India Grant — Cancer Research UK (CRUK) Biotherapeutics Drug Discovery Programme, UK