近期论文
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Representative Publications
Chen L., Heikkinen L., Wang C., Yang Y., Sun, H, Wong G. Trends in the development of miRNA bioinformatics tools. Briefings in Bioinformatics, bby054, 2018.
Qu M, Xu K, Li Y, Wong G, Wang D. Using acs-22 mutant Caenorhabditis elegans to detect the toxicity of nanopolystyrene particles. Sci Total Environ. 2018 Jun 20;643:119-126.
Chen L, Heikkinen L, Wang C, Yang Y, Knott KE, Wong G. miRToolsGallery: a tag-based and rankable microRNA bioinformatics resources database portal. Database (Oxford). 2018 Jan 1;2018.
Wang C, Saar V, Leung KL, Chen L, Wong G. Human amyloid β peptide and tau co-expression impairs behavior and causes specific gene expression changes in Caenorhabditis elegans. Neurobiol Dis. 2018 Jan;109(Pt A):88-101.
Wang C, Chen L, Yang Y, Zhang M, Wong G. Identification of bladder cancer prognostic biomarkers using an ageing gene-related competitive endogenous RNA network. Oncotarget. 2017 Dec 4;8(67):111742-111753.
Zhao, L., Qu, M., Wong G, Wang, D. Transgenerational toxicity of nanopolystyrene particles in the range of μg L−1 in the nematode Caenorhabditis elegans. Environ. Sci.: Nano, 2017,4, 2356-2366.
Riveiro AR, Mariani L, Malmberg E, Amendola PG, Peltonen J, Wong G, Salcini AE. JMJD-1.2/PHF8 controls axon guidance by regulating Hedgehog-like signaling. Development. 2017 Mar 1;144(5):856-865.
Rudgalvyte M, Peltonen J, Lakso M, Wong G. Chronic MeHg exposure modifies the histone H3K4me3 epigenetic landscape in Caenorhabditis elegans. Comp Biochem Physiol C Toxicol Pharmacol. 2017 Jan;191:109-116.
Lussi YC, Mariani L, Friis C, Peltonen J, Myers TR., Krag C, Wong G, Salcini AE. Impaired removal of H3K4 methylation affects cell fate determination and gene transcription. Development. 2016 Oct 15;143(20):3751-3762.
Lehtonen Š, Jaronen M, Vehviläinen P, Lakso M, Rudgalvyte M, Keksa-Goldsteine V, Wong G, Courtney MJ, Koistinaho J, Goldsteins G.. Inhibition of Excessive Oxidative Protein Folding Is Protective in MPP+ Toxicity-Induced Parkinson’s Disease Models. Antioxid Redox Signal. 2016 Sep 10;25(8):485-97.
Rudgalvyte M, Peltonen J, Lakso M, Nass R, Wong G. RNA-Seq Reveals Acute Manganese Exposure Increases Endoplasmic Reticulum Related and Lipocalin mRNAs in Caenorhabditis elegans. J Biochem Mol Toxicol. 2016 Feb;30(2):97-105.
Chen L, Heikkinen L, Emily Knott K, Liang Y, Wong G. Evolutionary conservation and function of the human embryonic stem cell specific miR-302/367 cluster. Comp Biochem Physiol Part D Genomics Proteomics. 2015 Dec;16:83-98
Asikainen S, Heikkinen L, Juhila J, Holm F, Weltner J, Trokovic R, Mikkola M, Toivonen S, Balboa D, Lampela R, Icay K, Tuuri T, Otonkoski T, Wong G, Hovatta O. Selective microRNA-Offset RNA expression in human embryonic stem cells. PLoS One. 2015 Mar 30;10(3):e0116668.
Korpelainen E, Tuimala J, Somervuo P, Huss M, Wong G (2014) RNA-seq Data Analysis: A Practical Approach, Chapman & Hall/CRC Mathematical and Computational Biology Paperback – ISBN-13: 978-1466595002, 288 pages.
Rudgalvyte M, VanDuyn N, Aarnio V, Heikkinen L, Peltonen J, Lakso M, Nass R, Wong G. Methylmercury exposure increases lipocalin related (lpr) and decreases activated in blocked unfolded protein response (abu) genes and specific miRNAs in Caenorhabditis elegans. Toxicol Lett. 2013, 222(2):189-96.
Srinivasan J, Dillman AR, Macchietto MG, Heikkinen L, Lakso M, Fracchia KM, Antoshechkin I, Mortazavi A, Wong G, Sternberg PW. The Draft Genome and Transcriptome of Panagrellus redivivus are Shaped by the Harsh Demands of a Free-Living Lifestyle. Genetics. 2013, 193(4):1279-95.
Kurronen A, Pihlaja R, Pollari E, Kanninen K, Storvik M, Wong G, Koistinaho M, Koistinaho J Adult and neonatal astrocytes exhibit diverse gene expression profiles in response to beta amyloid ex vivo. World Journal of Neuroscience, 2012, 2:57-67.
Huumonen K, Immonen HK, Baverstock K, Hiltunen M, Korkalainen M, Lahtinen T, Parviainen J, Viluksela M, Wong G, Naarala J, Juutilainen J. Radiation-induced genomic instability in Caenorhabditis elegans.
Mutat Res. 2012, 748:36-41.
Aarnio V, Lehtonen M, Storvik M, Callaway JC, Lakso M, Wong G. Caenorhabditis Elegans Mutants Predict Regulation of Fatty Acids and Endocannabinoids by the CYP-35A Gene Family. Front Pharmacol. 2011, 2:12.
Kurki MI, Paananen J, Storvik M, Ylä-Herttuala S, Jääskeläinen JE, von Und Zu Fraunberg M, Wong G, Pehkonen P. TAFFEL: Independent Enrichment Analysis of gene sets. BMC Bioinformatics, 2011, 12:171.
Heikkinen L, Kolehmainen M, Wong G. Prediction of microRNA targets in Caenorhabditis elegans using a self-organizing map. Bioinformatics, 2011, 27:1247-1254.Reisner K, Lehtonen M, Storvik M, Jantson T, Lakso M, Callaway JC, Wong G. Trans fat diet causes decreased brood size and shortened lifespan in Caenorhabditis elegans delta-6-desaturase mutant fat-3. J Biochem Mol Toxicol. 2011 25:269-279. Top 10 most accessed from the journal 8/2012.
Rytinki MM, Lakso M, Pehkonen P, Aarnio V, Reisner K, Peräkylä M, Wong G, Palvimo JJ. Overexpression of SUMO perturbs the growth and development of Caenorhabditis elegans. Cell Mol Life Sci. 2011, 68:3219-3232.
Kurki M, Häkkinen SK, Frösen J, Tulamo R, Fraunberg M, Wong G, Tromp G, Niemelä M, Hernesniemi J, Jääskeläinen JE, Ylä-Herttuala S: Upregulated signaling pathways in ruptured human saccular intracranial aneurysm wall: an emerging regulative role of Toll like receptor signaling and NF-κB, HIF1A and ETS transcription factors. Neurosurgery, 2011, 68:1667-75; discussion 1675-6.
Vanduyn N, Settivari R, Wong G, Nass R. SKN-1/Nrf2 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of methylmercury toxicity. Toxicol Sci. 2010, 118:613-624.
Aarnio V, Storvik M, Lehtonen M, Asikainen S, Reisner K, Callaway J, Rudgalvyte M, Lakso M, Wong G. Fatty acid composition and gene expression profiles are altered in aryl hydrocarbon receptor-1 mutant Caenorhabditis elegans. Comp Biochem Physiol C Toxicol Pharmacol 2010, 151:318-24.
Asikainen S, Rudgalvyte M, Heikkinen L, Louhiranta K, Lakso M, Wong G, Nass R. Global microRNA Expression Profiling of Caenorhabditis elegans Parkinson’s Disease Models. J Mol Neurosci 2010, 41:210-218. Among first reports to identify microRNA changes in Parkinson’s disease.
Paananen J, Ciszek R, Wong G. Varietas: a functional variation database portal. Database 2010, vol. 2010, article ID baq016, doi:10.1093/database/baq016 “Tool of the week” in OpenHelix.
Pehkonen P, Wong G, Törönen P. Heuristic Bayesian segmentation for discovery of coexpressed genes within genomic regions. IEEE/ACM Trans Comput Biol Bioinform 2010, 7:37-49.
Storvik M, Arguel MJ, Schmieder S, Delerue-Audegond A, Li Q, Qin C, Vital A, Bioulac B, Gross CE, Wong G, Nahon JL, Bezard E. Genes regulated in MPTP-treated macaques and human Parkinson’s disease suggest a common signature in prefrontal cortex. Neurobiol Dis. 2010, 38:386-394.
Small noncoding RNAs:
Rudalvyte M.; Peltonen J.; Lakso M.; Nass R.; Wong G. (2016) RNA‐Seq Reveals Acute Manganese Exposure Increases Endoplasmic Reticulum Related and Lipocalin mRNAs in Caenorhabditis elegans. Journal of biochemical and molecular toxicology. 2016 Feb;30(2):97-105.
Chen L.; Heikkinen L.; Knott K.E. Liang Y.; Wong G. (2015) Evolutionary conservation and function of the human embryonic stem cell specific miR-302/367 cluster. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics 2015 Dec;16:83-98.
Asikainen S.; Heikkinen L.; Juhila J.; Holm F.; Weltner J.; Trokovic R.; Hovatta O.; Wong G. (2015) Selective MicroRNA-Offset RNA Expression in Human Embryonic Stem Cells. PloS one. 10(3):e0116668.
Srinivasan J, Dillman AR, Macchietto MG, Heikkinen L, Lakso M, Fracchia KM, Antoshechkin I, Mortazavi A, Wong G, Sternberg PW (2013)The Draft Genome and Transcriptome of Panagrellus redivivus are Shaped by the Harsh Demands of a Free-Living Lifestyle. Genetics. 193(4):1279-95.
Wong G and Nass R (2012) miRNAs and their putative roles in the development and progression of Parkinson’s disease. Front. Genetics. 3:315.
Asikainen S, Rudgalvyte M, Heikkinen L, Louhiranta K, Lakso M, Wong G, Nass R (2010) Global microRNA Expression Profiling of Caenorhabditis elegans Parkinson’s Disease Models. J Mol Neurosci 41(1):210-218.
Asikainen S, Heikkinen L, Wong G, Storvik M (2008) Functional characterization of endogenous siRNA target genes in Caenorhabditis elegans. BMC Genomics, 9:270.
Bioinformatic Tools:
Korpelainen E, Tuimala J, Somervuo P, Huss M, Wong G (2014) RNA-seq Data Analysis: A Practical Approach, Chapman & Hall/CRC Mathematical and Computational Biology Paperback – ISBN-13: 978-1466595002.
Kurki MI, Paananen J, Storvik M, Ylä-Herttuala S, Jääskeläinen JE, von Und Zu Fraunberg M, Wong G, Pehkonen P (2011)TAFFEL: Independent Enrichment Analysis of gene sets. BMC Bioinformatics;12:171.
Heikkinen L, Kolehmainen M, Wong G (2011) Prediction of microRNA targets in Caenorhabditis elegans using a self-organizing map. Bioinformatics. 27(9):1247-54.
Paananen J, Ciszek R, Wong G (2010) Varietas: a functional variation database portal. Database, vol. 2010, article ID baq016, doi:10.1093/database/baq016
Pehkonen P, Wong G, Törönen P (2010)Heuristic Bayesian segmentation for discovery of coexpressed genes within genomic regions. IEEE/ACM Trans Comput Biol Bioinform, 7(1):37-49.