个人简介

Education PhD Department of Biology, University of Utah, Salt Lake City, UT, USA (1992) MS Institute of Hydrobiology, Academia Sinica, Wuhan, China (1984) BS Department of Biology, West China Normal University, Nanchong, China (1982) Academic and Professional Experience 2014.12-present Faculty Dean / Chair Professor, Faculty of Health Sciences, University of Macau 2000.3-2014.11 Senior Investigator, Senior Biomedical Research Service (SBRS) Chief, Mammalian Genetics Section, National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, MD, USA 1995.5-2000.3 Investigator (Tenure-Track), Laboratory of Biochemistry and Metabolism, NIDDK, NIH, Bethesda, MD, USA 1992.7-1995.5 Associate, Howard Hughes Medical Institute. Fellow, Genetics Department, Harvard Medical School, Boston, MA, USA 1986.9-1992.7 Dept. of Biology, University of Utah, SLC, UT, USA 1984.9-1986.9 Assistant Investigator, Institute of Hydrobiology, Academia Sinica, Wuhan, China Professional Activities Scientific Leadership and Editorial ExperienceFounding Editor-in-Chief of “International Journal of Biological Sciences” since 2006 (http://www.biolsci.org), IF (2013): 4.372 -Organizing reviewing, extensive interaction with authors/reviewers/editors, and making decisions regarding all the manuscripts received for publication in the journal. President (2008) for Baltimore-Washington DC Chapter, Society of Chinese Bioscientists in America (SCBA) -Direct over 150 scientists to facilitate networking, discuss their research interesting, and organize annual scientific retreat. President-elect (for 2016-2017) for SCBA. NIH Equal Opportunity and Employment Committee (2008-2011) NIH Central Tenure Committee (2013-2014) ORWH-FAES-NIH High School Summer Student Program (2013-2014) Course Outlines Advanced Molecular Cell Biology

研究领域

Oncogenes and tumor suppressor genes, Sirtuins; Cancer, Metabolic diseases; Aging; Stem cells, Cancer metastasis, Drug development, Cell cycle, Bioinformatics, Genome stability, Development, Gene targeting

Ongoing Research Grants and Support Chair Professor DENG (PI) Since 2015 Macao Government Grant 065A2 DENG (PI) 2016 – 2019 Single cell research for BRCA1-related breast stem cells and breast cancer stem cells Macao Government Grant 094A3 DENG (PI) 2016 – 2019 Using precise medicine approaches to identify cancer drivers for personalized cancer therapy Macao Government Grant MYRG2016-00139-FHS DENG (PI) 2016 – 2019 Use Sleeping Beauty system mediated insertion mutagenesis in BRCA1 breast tissue specific gene knockout mice to identify cancer-promoting network Macao Government Grant MYRG2016-00132-FHS DENG (PI) 2016 – 2019 Identification of TGF-β signaling pathway mediated signaling for the inhibition of cancer metastasis Macao Government Grant MYRG2017-00113-FHS DENG (PI) 2017 – 2020 Fibroblast Growth Factor Receptor 2 (FGFR2) and Its Cooperating Factors in Mammary Tumor Initiation and Progression Patents Patent: AU5028500, Publication date: 2001-12-03 Inventors: Anita B Robert, GS. Ashcorft, A Russo, James B. Mitchell, and Chuxia DENG Title: Inhibition of smad3 to prevent fibrosis and improve wound healing http://v3.espacenet.com/textdoc?DB=EPODOC&I=AU5028500&F=0

近期论文

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30 representative publications Chuxia DENG, and Mario, R. Capecchi (1992). Reexamination of gene targeting frequency as a function of the extent of homology between the targeting vector and the target locus. Mol. and Cell. Biol. 12, 3365-3371. Chuxia DENG, Pumin Zhang, J. Wade Harper, Stephen J. Elledge, and Philip Leder (1995). Mice lacking p21cip1/waf1undergo normal development, but are defective in G1 checkpoint control. Cell 82, 675-684. PMID: 7664346. Chuxia DENG, Tony Wynshaw-Boris, Fen Chou, Ann Kuo and Philip Leder (1996). FGFR-3 is a negative regulator in bone growth. Cell 84, 911-921. PMID: 8601314. Xiaoling Xu, Zoë Weaver, Steven P. Linke, Cuiling Li, Jessica Gotay, Xin-Wei Wang, Curtis C. Harris, Thomas Ried and Chuxia DENG (1999). Centrosome Amplification and a Defective G2-M Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform-Deficient Cells. Molecular Cell 3, 389-396. PMID: 10198641. Xiaoling Xu, Kay-Uwe Wagner, Cuiling Li, Anthony Wynshaw-Boris, Lothar Hennighausen and Chuxia DENG(1999). Conditional knockout of BRCA1 in mammary glands results in abnormal ductal morphogenesis and tumor formation. Nature Genetics 22, 37-43. PMID: 10319859. Xiaoling Xu, Wenhui Qiao, Steven P. Linke, Liu Cao, Wen-Mei Li, Cuiling Li, Curtis C. Harris, and Chuxia DENG(2001). Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle, genomic stability and tumorigenesis. Nature Genetics 28, 266-271. PMID: 11431698. Yi Tang, M. Katuri, A. Dillner, B. Mishra*, Chuxia DENG*, (*Corresponding authors). and L. Mishra*.(*Corresponding authors) (2003). Disruption of TGF-beta signaling in ELF-beta-spectrin deficient mice. Science299, 574-7. PMID: 12543979. Liu Cao, Wenmei Li, Sangsoo Kim, Steven G. Brodie, and Chuxia DENG (2003). Senescence, ageing and malignant transformation mediated by p53 in mice lacking Brca1 exon 11 isoform. Genes and Development 17, 201-213. James MA Turner*, Olga Aprelikova*, Xiaoling Xu*(*equal contribution), Ruihong Wang, Sangsoo Kim, GVR Chandramouli, JC Barrett, Paul S Burgoyne, and Chuxia DENG (2004). BRCA1 interacts with ATR and H2AX and plays an essential role in meiotic sex chromosome inactivation during spermatogenesis. Current Biology 14(23):2135-42. Ruihong Wang, Cuiling Li, Xiaoling Xu, Yin Zheng, Cuiying Xiao, Patricia Zerfas, Sharon Cooperman, Michael Eckhaus, Tracey Rouault, Lope Mishra, and Chuxia DENG (2005). A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metabolism 2(6):399-409. PMID: 16330325. Xiaoling Xu, S. Kobayashi, W. Qiao, C. Li, C. Xiao, S. Radaeva, B. Stiles, R.H. Wang, N. Ohara, T. Yoshino, LeRoith, M.S. Torbenson, G.J. Gores, H. Wu, B. Gao and Chuxia DENG (2006). Induction of intrahepatic cholangiocellular carcinoma by liver specific disruption of Smad4 and Pten in mice. Journal of Clinic Investigation116(7):1843-1852. Chuxia DENG. (2006). BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution. Nucleic Acids Res. 34(5):1416-26. Xiao C#, Sharp JA# (#equal contribution), Kawahara M, Davalos AR, Difilippantonio MJ, Hu Y, Li W, Cao L, Buetow K, Ried T, Chadwick BP, Chuxia DENG* (*Corresponding authors), Panning B*(*Corresponding authors). (2007). The XIST noncoding RNA functions independently of BRCA1 in X inactivation. Cell 128(5):977-89. Shukla V, Coumoul X, Wang RH, Kim HS, Chuxia DENG (2007). RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis. Nat Genet. 39(9):1145-50. PMID: 17694057. Wang RH, Sengupta K, Li C, Kim HS, Cao L, Xiao C, Kim SS, Xu X, Zheng Y, Chilton B, Jia R, Zheng ZM, Appella E, Wang XW, Ried T, and Chuxia DENG (2008). Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell 14, 312–323. PMCID: PMC2643030. Wang RH, Zheng Y, Kim HS, Xu X, Cao L, Luhasen T, Lee MY, Xiao C, Vassilopoulos A, Chen W, Man YG, Hung MC, Finkel T, and Chuxia DENG (2008). Interplay among BRCA1, SIRT1, and SURVIVIN during BRCA1-associated Tumorigenesis. Mol. Cell 32, 11–20. PMCID: PMC2577018. Toren Finkel, Chuxia DENG *(*Corresponding author), Raul Mostoslavsky (2009). Recent progress in the biology and physiology of sirtuins. Nature, 460(7255):587-91. PMID: 19641587. Liu Cao, Xioaling Xu, Samuel F. Bunting, Rui-Hong Wang, Jie Liu, Longyue L. Cao, Junjie Chen, Andre Nussenzweig, Chuxia DENG* (*Corresponding author) and Toren Finkel* (*Corresponding author) (2009). A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency. Molecular Cell, 35(4):534-41. Hyun-Seok Kim#, Krish Patel# (#equal contribution), Kristi Muldoon-Jacobs, Kheem S. Bisht, Nukhet Aykin-Burns, J. Daniel Pennington, Riet van der Meer, Phuongmai Nguyen, Jason Savage, Kjerstin M. Owens, Athanassios Vassilopoulos, Ozkan Ozden, Keshav K. Singh, Sarki A. Abdulkadir, Douglas R. Spitz, Chuxia DENG*(*Corresponding authors), and David Gius* (*Corresponding authors). (2010). SIRT3 is a Mitochondrially Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress. Cancer Cell, 17, 41-52. Hyun-Seok Kim, Cuiying Xiao, Rui-Hong Wang, Tyler Lahusen, Xiaoling Xu, Athanassios Vassilopoulos, Guelaguetza Vazquez-Ortiz, Won-Il Jeong, Ogyi Park, Sung Hwan Ki, Bin Gao, and Chuxia DENG. (2010). Hepatic specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. Cell Metabolism, 12(3):224-36. PMCID: PMC2935915. Hyun-Seok Kim, Athanassios Vassilopoulos, Rui-Hong Wang, Tyler Lahusen, Zhen Xiao, Xiaoling Xu, Cuiling Li, Timothy D. Veenstra, Bing Li, Hongtao Yu, Junfang Ji, Xin Wei Wang, Seong-Hoon Park, Yong I. Cha, David Gius, and Chuxia DENG. (2011). SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity. Cancer Cell, 20, 487–499. PMCID: PMC3199577. Seung Min Jeong* (equal contribution), Cuiying Xiao* (equal contribution), Lydia W.S Finley, Tyler Lahusen, Amanda L. Souza, Kerry Pierce, Ying-Hua Li, Xiaoxu Wang, Gaëlle Laurent, Natalie J. German, Xiaoling Xu, Cuiling Li, Rui-Hong Wang, Jaewon Lee, Alfredo Csibi, Richard Cerione, John Blenis, Clary B. Clish, Alec Kimmelman, Chuxia DENG* (Corresponding authors) & Marcia C. Haigis* (Corresponding authors) (2013). SIRT4 is a tumor suppressor that regulates cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. Cancer Cell, 23(4):450-63. Willis NA, Chandramouly G, Huang B, Kwok A, Follonier C, Chuxia DENG, Scully R. (2014). BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks. Nature. 2014 Apr 28. doi: 10.1038/nature13295. Masri S, Rigor P, Cervantes M, Ceglia N, Sebastian C, Xiao C, Roqueta-Rivera M, Chuxia DENG, Osborne TF, Mostoslavsky R, Baldi P, Sassone-Corsi P. (2014). Partitioning Circadian Transcription by SIRT6 Leads to Segregated Control of Cellular Metabolism. Cell. 2014 Jul 31;158(3):659-72. PMID: 25083875 Athanassios Vassilopoulos, Yohei Tominaga, Hyun-Seok Kim, Tyler Lahusen, Bing Li, Hongtao Yu, David Gius and Chuxia DENG. (2015). WEE1 Murine Deficiency Induces Hyper-activation of APC/C and Results in Genomic Instability and Carcinogenesis. Oncogene. 34(23):3023-35. Tyler J. Lahusen, and Chuxia DENG. (2015). SRT1720 induces lysosomal-dependent cell death in breast cancer cells. Molecular Cancer Therapy. 14(1):183-92. doi: 10.1158/1535-7163. Ada Hang-Heng Wong and Chuxia DENG (2015). Precision medicine for personalized cancer therapy. Int J Biol Sci. Nov 17;11(12):1410-2. doi: 10.7150/ijbs.14154. Qiang Chen, Wenhui Hao, Cuiying Xiao, Ruihong Wang, Xiaoling Xu, Huiyan Lu, Weiping Chen, Chuxia DENG(2017). SIRT6 is Essential for Adipocyte Differentiation through Regulating Mitotic Clonal Expansion. Cell Reports. Mar 28;18(13):3155-3166. doi: 10.1016/j.celrep.2017.03.006 Tyler J. Lahusen, Seung-Jin Kim, Kai Miao, Zebin Huang, Xiaoling Xu and Chuxia DENG. (2018). BRCA1 function in the intra-S checkpoint is activated by acetylation via a pCAF/SIRT1 axis. Oncogene, Apr;37(17):2343-2350. doi: 10.1038/s41388-018-0127-1. Sun H, Miao Z, Zhang X, Chan UI, Su SM, Guo S, Wong CKH, Xu X, Chuxia DENG. 2018. Single-cell RNA-Seq reveals cell heterogeneity and hierarchy within mouse mammary epithelia. J Biol Chem. Jun 1;293(22):8315-8329. doi: 10.1074/jbc.RA118.002297.

学术兼职

Editorial Board of “Developmental Dynamics” since 2003 Editorial Board of “Cancer Biology & Therapy” since 2002 Editorial Board of “Cancer Epidemiology” from 2009-2014 Editorial Board of “Chinese Journal of Biotechnology” since 2007 Editorial Board of “Cell & Bioscience” since 2012 Editorial Board of “Journal of Genomics” since 2011