个人简介
Dr. Paolo Coghi is University lecturer specializing in Organic Chemistry with 10 years of postdoctoral research experience covering Pharmaceutical Science, Drug Design, Biochemistry with 24 peer reviewed journals internationally and 1 patent. Currently is laboratory teacher at school of Pharmacy for course Fundamental of chemistry and Medicinal chemistry.
He received his MPhil degree (2005) from Milan’s University Statale. In 2008, he received his Ph.D. Degree from the University of Milan and then worked as post-doctoral research fellow at National Research Council in 2009-11 in project ‘“Hybrid nanoparticles with biomedical applications” in collaboration with CISI (Center for biomolecular interdisciplinary studies and industrial applications).
From 2011 to 2013 he worked at Bicocca University of Milan in project “Study and analysis of new photosensible polymers” in collaboration with Research Center “Donegani institute” of ENI. He continued in 2014 with project “Study of morphology of photosensible polymers”.
He has been involved in teaching activities (“Chemistry I” course) for the Chemical Sciences and Technologies (Bachelor), University of Milano-Bicocca 2012-14.
From 2015 to 2017 has collaborated at SKL-State Key Laboratory of Chinese Medicine in synthesis of triterpenoids Ca-ATPase (SERCA) inhibitors.
Dr Coghi has been involved in numerous European project (“Development of New Drugs for the Treatment of Malaria"ANTIMAL 2005-2011 and COST B22 “Drug development for parasite disease” 2007, MIUR Italian financed projects and international collaboration (MRC flagship project 2014 and MRC 2015-18 “Rational Development of Combinations of Known and Novel Drugs for Chemotherapy of Cancer” with North-West University, South Africa).
His research cover three major research, including infective disease, Medicinal chemistry and study of mechanism of action of drugs.
Membership toWorld Federation of Chinese medicine Societies from December 2015.
He is also reviewers for many journal, including Phytochemistry review, journal of Ethnopharmacology, Chemmedchem, Biomedical Reports, International journal of Molecular medicine, Oncology Letters, Bioorganic and Medicinal chemistry.
学历:
2005 MSc in Chemistry and Pharmaceutical Technology, University of Milan, Italy. Title: “Parallel synthesis and antileishmanial activity of ether-linked phospholipid”Supervisor: Prof. Sergio Romeo (University of Milan, Department of Pharmaceutical Science). Final grade 103/110.
2008 PhD in Pharmaceutical Science, University of Milan, Italy, Title: “Synthesis and mechanism of action of antimalarial compounds” Supervisor : Dr. Diego Monti (National Research Council, ISTM-CNR, Milan). Final grade Excellent.
⼯作履历:
2008-2011, University of Milan, Italy Title: “Hybrid nanoparticles with biomedical applications”Supervisor: Prof. Pierfausto Seneci at CISI (Center for biomolecular interdisciplinary studies and industrial applications) and National Research Council ISTM-CNR Milan; Dr. Diego Monti (National Research Council)
2011-2013, University of Milan Bicocca, Italy Title: “Study and analysis of new photosensible polymers”
Supervisor: Prof. Antonio Papagni, Dr. Vincenzo Malatesta (University of Milan Bicocca) in collaboration with Research Center “Donegani Institute” of ENI (Novara, Italy).
Oct 2013-Mar 2015, University of Milan Bicocca, Italy Title: “Study of morphology of photosensible polymers”Supervisor: Prof. Antonio Papagni, Dr. Vincenzo Malatesta (Milan Bicocca) in collaboration with Research Center “Donegani Institute” of ENI (Novara, Italy).
Sep 2015-Sep 2017, Macau University of Science and Technology, Macau Title: "Lead optimization of triterpenoids as sarcoplasmic/endoplasmic reticulum Ca-ATPase (SERCA) pro-inhibitor for therapeutic intervention of prostrate cancer. Supervisor: Dr. Vincent Kam Wai Wong (State Key Laboratory of Quality Research in Chinese Medicine).
教学科目：Pharmaceutical chemistry, Organic chemistry
研究领域
Chemistry of Natural compound. Anti-infective disease (Malaria, Leshmania), Anticancer therapy, Material chemistry, Organic Solar cells.
近期论文
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近年发表的主要 SCI 期刊论⽂:
1. Luca Vaghi, Mattia Coletta, Paolo Coghi, Ivan Andreosso, Luca Beverina, Riccardo Ruffo and Antonio Papagni. Fluorine substituted non symmetric phenazines: a new synthetic protocol from polyfluorinated azobenzenes. Arkivoc 2019, 1970.
2. Carolyne Chepkirui, Purity Jael Ochieng, Biswajyoti Sarkar, Chiranjib Pal, Paolo Coghi, Hoseah M. Akala, Solomon Derese, Albert Ndakala, Matthias Heydenriech, Vincent K. W. Wong, Máté Erdélyi, Abiy Yenesew Bioactive Flavonoids from Mundulea sericea (in preparation, October 2019).
3. Moses Andima, Paolo Coghi, Crispus M. Ngule, Li Jun, , Albert J Ndakala , Abiy Yenesew and Solomon Derese . In vitro antiproliferative and in silico anticancer mechanism of action of secondary metabolites from Zanthoxylum zantoxyloides. Phytomedicine (submitted august 2019).
4. Daniel Buyinza, Li Jun Yang, Solomon Derese, Albert Ndakala, Paolo Coghi, Matthias Heydenreich, Vincent Kam Wai Wong, Heiko M. Möller, Abiy Yenesew. Cytotoxicity of Isoflavones from Millettia dura, Natural Product research, 2019, 1660335.
5. Giovanni Ribaudo, Paolo Coghi, Enrico Zanforlin, Yuki Yu Jun Wu, Yu Han, Alena Congling Qiu, Betty Yuen Kwan Law, Giuseppe Zagotto Vincent K. W. Wong,. Semi-synthetic isoflavones as BACE-1 inhibitors and P-glycoprotein
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ATPase stimulator against Alzheimer’s disease., Bioorg Chem. 2019;87:474-483. (Co- First author).
6. CIFAL: A Method for Rapid Screening of Anilide-containing AMPK Modulators Based on Computational Docking and Biological Validation Simon Wing Fai Mok, Wu Zeng, Yuzhen Niu, Paolo Coghi, Yujun Wu, Wai Man Sin, Sio Ian Ng, Flora Gordillo-Martinez, Jia Ying Gao, Betty Yuen Kwan Law, Liang Liu, Xiao Jun Yao, Vincent Kam Wai Wong , Journal: Frontiers in Pharmacology, section Experimental Pharmacology and Drug Discovery, 2018, 9, 710.
7. Souaibou Yaouba, Arto Valkonen, Paolo Coghi, Jiaying Gao, Eric M. Guantai, Solomon Derese, Vincent Kam Wai Wong, Máté Erdélyi, Abiy Yenesew. Crystal Structures and Cytotoxicity of ent-Kaurane-Type Diterpenoids from two Aspilia species, Molecules, 2018, 4; 23(12), E3199.
8. Novel peroxides as promising anticancer agents with unexpected depressed antimalarial activities. P.Coghi, Ivan A. Yaremenko, Parichat Prommana, Peter S. Radulov, Mikhail A. Syroeshkin, Yu Jun Wu , Jia Ying Gao, Floria M. Gordillo, Simon Mok, Vincent Kam Wai Wong, Chairat Uthaipibull, and Alexander O. Terent’ev. Chemmedchem. 2018 (Front Cover may, VIP paper, first author).
9. N-desmethyldauricine induces autophagic cell death in apoptosis-defective cells via Ca2+ mobilization Betty Yuen Kwan Law, Simon Mok, Paolo Coghi, Vincent Kam Wai Wong. Frontiers in Pharmacology 2017, 16, 8, 388.
10. Four flavones with modified prenyl groups from the stem of Tephrosia purpurea supsp leptostachya Yoseph Atilaw, Lois Muiva-Mutisya, Albert Ndakala, Hoseah M. Akala, Matthew L. Brown, Agnes C. Cheruiyot, Paolo Coghi, Vincent Kam Wai Wong, Abiy Yenesew, Máté Erdélyi. Molecules 2017, 10, 22(9).
11. Thalidezine, A Novel AMPK Activator, Eliminates Apoptosis-resistant Cancer Cells Through Energy-mediated Autophagic Cell Death, Law BYK, GordilloMartínez F, Qu YQ, Zhang N, Xu SW, P.Coghi, Mok SWF, Guo J, Zhang W, Leung ELH, Fan XX, Wu AG, Chan WK, Yao XJ, Wang JR, Liu L, Wong VKW. Oncotarget 2017, 2, 8(18), 30077-30091.
12. Autophagy degradation of epidermal growth factor in getifinib-resistant lung cancer -Su Wei Xu, Betty Yuen Kwan Law,Simon W.F. Mok, P. Coghi, Leung EL, Fan XX, , Zeng W, Leung CH, Ma DL, Liu L, Wong VKW. International journal of oncology, 2016; 49(4), 1576-88.
13. Paolo Coghi, Antonio Papagni, Riccardo Po, Anna Calabrese, Alessandra Tacca, Alberto Savoini Carolyne Reactivity of Decafluorobenzophenone and decafluoroazobenzene towards aromatic diamines: a potential entry to DonorAcceptor systems New Journal of Chemistry, 2015, 39, 3615-3623.
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