个人简介

EDUCATION : 1987 Ph.D., Department of Anatomy and Cell Biology, University of Illinois College of Medicine, Chicago, U.S.A. 1981 M.A., Department of Chemistry, University of Illinois at Chicago, Chicago, U.S.A. 1978 B.A., Double Major in Biology & Chemistry, Lewis University, Lockport, IL, U.S.A. PROFESSIONAL TRAINING: June, 1988 – Mar., 1991 Winston Foundation Fellow, Laboratory of Neurobiology and Behavior, Rockefeller University, New York, N.Y., USA Feb., 1987 - May, 1988 NIH Postdoctoral Fellow, Department of Physiology, Northwestern University Medical Center, Chicago, IL, USA ACADEMIC APPOINTMENTS: 2019-Present: Professor, Medical Faculty, Macao University of Science and Technology 2018-2019: Professor, Beijing Normal University-Hong Kong Baptist University, United International College 2015 - 2018: Professor, School of Biomedical Sciences (Merging of Anatomy, Physiology and Biochemistry), The University of Hong Kong 2006–2015: Professor, Department of Anatomy, The University of Hong Kong 2005–2006: Associate Professor, Department of Anatomy, The University of Hong Kong 1998-2005: Honorary Associate Professor, Department of Anatomy, The University of Hong Kong 1992–2005: Investigator, Institute of Molecular Biology, May, 2001 substantiated, The University of Hong Kong 1991-1998: Honorary Lecturer, Department of Anatomy, The University of Hong Kong 1991-1992:Research Officer, Institute of Molecular Biology, The University of Hong Kong 1988-1991: Winston Foundation Fellow, Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, USA 1987-1988: NIH Postdoctoral Fellow, Department of physiology, Northwestern University Medical Center, Chicago, USA, 1982-1987 Research and teaching assistant, Department of Anatomy and Cell Biology, Health Sciences Center, University of Illinois at Chicago, Chicago, IL, USA OTHER ACADEMIC APPOINTMENTS: 2007-Present: Visiting Professor, The Airforce Medical University (previously called The Fourth Military Medical University) 2018-Present: Honorary Professor, School of Biomedical Sciences, HKU 2019-Present: Honorary Professor, Beijing Normal-HKBU UIC, China 2017-Present: Honorary Professor, Chungnam National University Medical School, Korea 2007-2018: Honorary Professor, Dept Ophthalmology, The University of Hong Kong 2007-2010: Research Fellow (equivalent to Honorary Professor), Shanghai Jiao Tong University, China 2001-2011:Management Committee for the Area of Excellence in Molecular Neuroscience (hosting Institution, HKUST, Program Director Prof. Nancy Ip) 2012-present: Management Committee for the Theme-based Research Scheme (TBRS) Project “Stem Cell Stem for Nervous System Disorder” (T13-607/12R) UNDERGRADUATE TEACHING: 1978-1979: Department of Chemistry, University of Illinois at Chicago, IL., U.S.A. 1982 - 1987: Department of Anatomy (Histology and Gross Anatomy), College of Medicine University of Illinois, Chicago, IL, U.S.A. 1992 - 2016: Department of Anatomy Faculty of Medicine (Participated in teaching and examination for Histology and Gross Anatomy and Problem Based Learning tutoring to Medical students; Histology to Medical, Traditional Chinese Medicine, Nursing, Bioengineering, Pharmacy students) 2016- 2018: School of Biomedical Sciences, Faculty of Medicine (Organ system that integrate anatomy, biochemistry, and physiology) UNDERGRADUATE AND POSTGRADUATE TEACHING ADMINISTRATION: 1. Member and Chairman of Departmental Research Postgraduate Committee 2. Chair of Anatomy Departmental Postgraduate Symposium 4. Coordinator for Postgraduate Journal Club 5. Coordinator for Current Topics in Morphological Science 6. Departmental representative for Master of Medical Science Program 7. Coordinator for Histology 8. Recruit students from top Korean Universities for Graduate Programs in the Faculty of Medicine. 9. Serve as a reviewer for teaching assessment. 10. Invited to discuss the Anatomy teaching at the 4th International Anatomical Sciences and Cell Biology Conference, Hong Kong, Dec 4 – 6th, 2016. SUPERVISOR OF HIGH SCHOOL AND UNDERGRADUATE RESEARCH INTERNSHIPS: To provide research experience to younger students who aspire to be scientists I mentored several research interns in the past 10 years, including 1 high school students, 8 medical students, and 4 undergraduate students PRINCIPAL SUPERVISOR OF POSTGRADUATE STUDENTS: 34 PhD and MPhil students CO-SUPERVISOR OF POSTGRADUATE STUDENTS: 37 PhD and MPhil students

研究领域

Pathogenesis of diabetic and ischemic complications and drug discovery Cellular osmotic, oxidative and ischemic stress Development, degeneration and regeneration Diabetes mellitus and diabetes insipidus  Stem cells and drug discovery for stroke, Alzheimer’s Disease, Parkinson’s and depression Biopharmaceutical research for vascular disease

PATENTS OBTAINED: 1.Sookja Kim Chung, Stephen Chung and Chihiro Hibi, Preventive or therapeutic agent for cerebral ischemic injury or cerebral ischemia reperfusion in stroke, Filed on Aug 30, 2007, Patent No. 000144577 2. Sookja Kim Chung, Stephen Chung and Chihiro Hibi, Protective agent for retinal nerve or optic nerve, Patent Application 20100216856, 08/26/2010 3. Ip, Nancy Y, Ip, Fanny Chui Fun, Hu, Yueqing, Han, Yifan, Chung, Sookja Kim Heterodimers and methods of using them, United States Patent 7605265, Oct 20, 2009 4. Sookja Kim Chung, Stephen Chung and Chihiro Hibi, Protective agent for retinal nerve or optic nerve, European Patent Application, 13155114.5-1464, 23.04.13 CURRENT RESEARCH GRANTS 1.S.K. Chung, PI, To determine the role of exchange protein directly activated by cAMP in the blood-retinal barrier and pathogenesis of diabetic retinopathy, Health and Medical Research Fund, 13142231, HK$947,000, July 2016 – 2018 2. S.K. Chung, PI, Interaction between activated aldose reductase, non-enzymatic glycation, PKC and hexoamine pathways for the pathogenesis of diabetic complications, Health and Medical Research Fund, 13142221, HK$967,000, July 2016 – 2018 3. SK Chung, Travel grant to discuss collaborative research with the Fourth Military Medical University, Xian, China HKD12,482 4. Wai Ho Tang and SK Chung (co-PI), Guangdong and Hong Kong Joint Innovation Field of Scientific and Technological Cooperation Project. The role and mechanism of platelet transfer by miRNA-143/145 on diabetic vascular disease”, May 2017 to Apr 2019 Total cost: RMB1,000,000 5. SK Chung (PI), NSFC, Endothelin-1 and tanshinone IIA, Chinese RMB 540,000, Jan 2018 to Dec 31, 2021 6. Cheng Xiao (PI) and SK Chung (NSFC): RMB 250,000, Jan 2018 to Dec 31, 2021

近期论文

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LIST OF PUBLICATIONS: 143 full papers in ISI listed international journals 3 book chapters 4 invited review articles 6 242 conference papers 10 REPRESENTATIVE PUBLICATIONS: 2013 to 2018 Zeng Z, Xia L, Fan X, Ostriker AC, Yarovinsky T, Su M, Zhang Y, Peng X, Xie Y, Pi L, Gu X, Chung SK, Martin KA, Liu R, Hwa J, Tang WH. Platelet-derived miR-223 promotes a phenotypic switch in arterial injury repair. J Clin Invest. 2019 Mar 1;129(3):1372-1386. doi: 10.1172/JCI124508. Epub 2019 Feb 18. PubMed PMID: 30645204; PubMed Central PMCID: PMC6391113. Bian G, Yu C, Liu L, Fang C, Chen K, Ren P, Zhang Q, Liu F, Zhang K, Xue Q, Xiang J, Guo H, Song J, Zhao Y, Wu W, Chung SK, Sun R, Ju G, Wang J. Sphingosine 1-phosphate stimulates eyelid closure in the developing rat by stimulating EGFR signaling. Sci Signal. 2018 Oct 23;11(553). pii: eaat1470. doi: 10.1126/scisignal.aat1470. PubMed PMID: 30352949. He J, Xia M, Yeung PKK, Li J, Li Z, Chung KK, Chung SK, Xia J. PICK1 inhibits the E3 ubiquitin ligase activity of Parkin and reduces its neuronal protective effect. Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7193-E7201. doi: 10.1073/pnas.1716506115. Epub 2018 Jul 9. PubMed PMID: 29987020; PubMed Central PMCID: PMC6064985. Zhang SQ, Yung KK, Chung SK, Chung SS. Aldo-keto reductases-mediated cytotoxicity of 2deoxyglucose: A novel anticancer mechanism. Cancer Sci. 2018 Jun;109(6):1970-1980. doi: 10.1111/cas.13604. Epub 2018 May 3. PubMed PMID: 29617059; PubMed Central PMCID: PMC5989857 Liu XB, Lo CM, Cheng Q, Ng KT, Shao Y, Li CX, Chung SK, Ng IOL, Yu J, Man K. Oval Cells Contribute to Fibrogenesis of Marginal Liver Grafts under Stepwise Regulation of Aldose Reductase and Notch Signaling. Theranostics. 2017 Oct 24;7(19):4879-4893. doi: 10.7150/thno.20085. eCollection 2017. PubMed PMID: 29187911; PubMed Central PMCID: PMC5706107. Xu WW, Li B, Guan XY, Chung SK, Wang Y, Yip YL, Law SY, Chan KT, Lee NP, Chan KW, Xu LY, Li EM, Tsao SW, He QY, Cheung AL. Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression. Nat Commun. 2017 Feb 10;8:14399. doi: 10.1038/ncomms14399. PubMed PMID: 28186102; PubMed Central PMCID: PMC5309924. Patrick K.K.Yeung, Angela K.W.Lai, Hyo JinSon, XuZhang,, Stephen S.M.Chung & S K Chung, Aldose reductase deficiency leads to oxidative stress-induced dopaminergic neuronal loss and autophagic abnormality in an animal model of Parkinson's disease., Neurobiol Aging. 2017 Feb;50:119-133. https://doi.org/10.1016/j.neurobiolaging.2016.11.008 L Zhou, S L Ma, P K K Yeung, Y H Wong, K W K Tsim, K F So, L C W Lam, & S K Chung, Anxiety and depression with neurogenesis defects in exchange protein directly activated by cAMP 2-deficient mice are ameliorated by a selective serotonin reuptake inhibitor, Prozac., Translational Psychiatry (2016) 6, doi:10.1038/tp.2016.129, https://www.nature.com/articles/tp2016129.pdf Victor KL Hung, Patrick KK Yeung, Angela KW Lai, Maggie CY Ho, Amy CY Lo, Kevin C Chan, Ed XK Wu, Stephen SM Chung, Chi W Cheung, Sookja K Chung, Selective Astrocytic Endothelin-1 Overexpression Contributes to Dementia Associated with Ischemic Stroke by Exaggerating Astrocyte-Derived Amyloid Secretion . J Cereb Blood Flow Metab. 35(10):1687-96, 2015, http://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2015.109 Kai AK, Lam AK, Chen Y, Tai AC, Zhang X, Lai AK, Yeung PK, Tam S, Wang J, Lam KS, Vanhoutte PM, Bos JL, Chung SS, Xu A, Chung SK., Exchange protein activated by cAMP 1 (Epac1)-deficient mice develop β-cell dysfunction and metabolic syndrome. FASEB J. 2013 Oct;27(10):4122-35. doi: 10.1096/fj.13-230433. Epub 2013 Jun 27. http://www.fasebj.org/content/27/10/4122.short

学术兼职

REVIEWER FOR THE FOLLOWING JOURNALS: Diabetes; Biochim. Biophy Acta; Acta Pharmacologica Sinica; Diabetologia; Diabetes Care; Diabetes/Metabolism Research and Reviews Biochim Biophys Acta; Pharmacol Res; Diabetes and its complications; J. Neurochem.; Eur. J. of Biochem.; International J. Biochem. & Cell Biol.; International J. Andrology; J. of Biomedical Sci; Biological signal; The Journal of DNA Sequencing & Mapping; Neuroscience Letters; Neuro-signal; Molecular Genetics and Metabolism; IBRO Reports; Experimental Biology and Medicine; Clinical and Experimental Pharmacology and Physiology; Free Radical Biology and Medicine; J. Neuroscience Research; Experimental Eye Research; PLoS One; Genesis, The J Genetic and Development; Experimental Neurology; The Anatomical Record, Journal of Diabetes Investigation; Experimental Diabetes Research; Molecular Biology Reports; J. Peripheral Nervous System; J. of Diabetes Investigation; Liver International; Alcoholism: Clinical and Experimental Research; Experimental Gerontology; Developmental dynamics Society for Neurosciences American Association for the Advancement of Science The Rockefeller University Chapter of the Society of Sigma X  American Diabetes Association  The New York Academy of Science Hong Kong Society for Neuroscience  Korean Society for Neuroscience