段礼新 - 广州中医药大学 - 国际中医药转化医学研究所

研究领域

研究内容：综合运用多学科交叉技术，如基因组、转录组、代谢组，生物信息学技术，结合植物次生代谢物合成和积累的组织器官特异性，通过基因簇克隆与表达、基因敲除/敲入、异源表达等手段，对具有重要药用价值、低含量、结构新颖的天然产物生物合成途径，克隆并生化验证生物合成途径中的关键酶及基因，解析转录因子调控植物次生代谢的分子机制。研究方向1.药用植物活性天然产物生物合成途径解析研究方向2. 天然产物组合生物合成及代谢工程研究方向3. 药用植物活性天然产物调控研究

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Xiaojing Wang#, Chen Wang#, Lixin Duan#(co-first author), et al. Yuquan Xu *, István Molnár *. Rational Reprogramming of O‑Methylation Regioselectivity for Combinatorial Biosynthetic Tailoring of Benzenediol Lactone Scaffolds. Journal of the American Chemical Society. 2019,141:4355-4364. (Impact factor: 14.375) Mengyu Liu#, Cunjia Zhang#, Lixin Duan#(co-first author), et al, Xiaoquan Qi*, Zhonghai Ren*. CsMYB60 is a key regulator of flavonols and proanthocyanidans that determine the colour of fruit spines in cucumber. Journal of Experimental Botany.2018,70(1):69-84. (Impact factor: 5.354) Yuan Zhou#, Yongshuo Ma#, Jianguo Zeng#, Lixin Duan# (co-first author), et al, Yi Shang*, Sanwen Huang*. Convergence and divergence of bitterness biosynthesis and regulation in cucumber, melon and watermelon. Nature Plants. 2016, 28(2):16183. (Impact factor: 10.30) Lixin Duan, István Molnár, John Huge Snyder, Guo-an Shen, Xiaoquan Qi. * Discrimination and quantification of true biological signals in metabolomics analysis based on liquid chromatography-mass spectrometry. Molecular Plant, 2016, 9(8):1217-1220. (Impact factor: 9.326) Lixin Duan#, Tianlu Chen# (co-first author), et al, Luqi Huang*, Xiaoquan Qi*. Use of metabolomics approach to characterize Chinese medicinal material Huangqi. Molecular Plant. 2012, 5(2):376-386. (Impact factor: 9.326) Yi Shang#, Yongshuo Ma#, Yuan Zhou#, Huimin Zhang# (co-first author), Lixin Duan, et al, William J. Lucas, Sanwen Huang*. Biosynthesis, regulation, and domestication of bitterness in cucumber. Science. 2014, 28 (346):1084-1088. (Impact factor: 34.661) Yu Zhang # , Aijia Ji # (co-first author), Zhichao Xu, Hongmei Luo, Jingyuan Song*. The AP2/ERF transcription factor SmERF128 positively regulates diterpenoid biosynthesis in Salvia miltiorrhiza. Plant Molecular Biology. 2019, DOI:10.1007/s11103-0 19-00845-7. (Impact factor: 3.543) Aijia Ji, et al, Jingyuan Song*, Shilin Chen*. Genome-wide identification of the AP2/ERF gene family involved in active constituent biosynthesis in Salvia miltiorrhiza, Plant Genome. 2016, 9(2): DOI: 10.3835/plantgenome2015.08.0077.(Impact factor: 2.923) Aijia Ji #, Jing Jia #, Zhichao Xu, Ying Li, Wu Bi, Fengming Ren, Chunnian He, Jie Liu, Kaizhi Hu*, Jingyuan Song*. Transcriptome-guided Ming of Genes Involved in Crocin Biosynthesis. Frontiers in Plant Science. 2017 8:518. doi: 10.3389/fpls.2017.00518. (Impact factor: 3.677)