Wong, Lu Shin - The University of Manchester

个人简介

Lu Shin Wong graduated with a Bachelor of Pharmacy from the University of Nottingham in 1997. He then practised as a hospital pharmacist for four years while completing his postgraduate diploma in clinical pharmacy from the University of Bradford. He subsequently undertook his PhD studies in organic and analytical chemistry at the University of Southampton with Prof. Mark Bradley. Upon completing this in 2005, he joined the Manchester Interdisciplinary Biocentre as a postdoctoral research associate with Prof. Jason Micklefield on the application of chemical biology to surface chemistry and biomolecular-array technologies. In 2008, Lu Shin was awarded an EPSRC Life Science Interface research fellowship, which enabled him to work with Prof. Chad A. Mirkin at the International Institute for Nanotechnology, Northwestern University. In 2011, he was appointed as a lecturer at the School of Chemistry.

研究领域

Our multidisciplinary research combines chemical biology and nanotechnology toward developing applications for the life sciences, sustainable chemical processing and nanofabrication. These research areas are thus underpinned by components of molecular biology (to enable the mutagenic engineering of recombinant proteins), organic chemistry (for the synthesis of building blocks, linkers and enzyme substrates) and surface nanofabrication (to produce tailored materials as platforms for our applications).

近期论文

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Joseph Hosford, Sarah A. Shepherd, Jason Micklefield, Lu Shin Wong. A High-Throughput Assay for Arylamine Halogenation Based on a Peroxidase Mediated Quinone-Amine Coupling with Applications in the Screening of Enzymatic Halogenations. Chemistry: A European Journal. 2014; 20: 16759-6763. eScholarID:233555 | DOI:10.1002/chem.201403953 Stewart A. M. Carnally Lu Shin Wong. Harnessing catalysis to enhance scanning probe nanolithography. Nanoscale. 2014; 6: 4998-5007. eScholarID:223991 | DOI:10.1039/C4NR00618F L. S. Wong, C. V. Karthikeyan. A Multidisciplinary Approach to Protein Nanoarrays. 2012: -. eScholarID:187454 Anna-Winona Struck, Mark L. Thompson, Lu Shin Wong and Jason Micklefield. S-Adenosyl-Methionine-Dependent Methyltransferases: Highly Versatile Enzymes in Biocatalysis, Biosynthesis and Other Biotechnological Applications. ChemBioChem. 2012; 13: 2642-2655. eScholarID:192041 | DOI:10.1002/cbic.201200556 L. R. Giam, M. D. Massich, L. Hao, L. S. Wong, C. C. Mader, C. A. Mirkin. Scanning probe-enabled nanocombinatorics define the relationship between fibronectin feature size and stem cell fate. Proceedings of the National Academy of Sciences of the United States of America. 2012; 109(12): 4377-4382. eScholarID:162690 | DOI:10.1073/pnas.1201086109 Wong L, Karthikeyan C, Eichelsdoerfer D, Micklefield J, Mirkin C. A Methodology for Preparing Nanostructured Biomolecular Interfaces with High Enzymatic Activity. RSC Nanoscale. 2012; 4: 659-666. eScholarID:141815 | DOI:10.1039/c1nr11443c Alang Ahmad S, Wong L, ul-Haq E, Hobbs J, Leggett G, Micklefield J. Protein micro- and nano-patterning using aminosilanes with protein-resistant photolabile protecting groups. J. Am. Chem. Soc. 2011; 133: 2749-2759. eScholarID:141819 | DOI:10.1021/ja1103662 Chai J, Wong L, Giam L, Mirkin C. Single-molecule protein arrays enabled by scanning probe block copolymer lithography. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108(49): 19521-19525. eScholarID:141821 | DOI:10.1073/pnas.1116099108 Giam L, Senesi A, Liao X, Wong L, Chai J, Eichelsdoerfer D, Shim W, Rasin B, He S, Mirkin C. Direct-write scanning probe lithography: towards a desktop fab. Proc. SPIE. 2011; 8031: 803103-1. eScholarID:141818 | DOI:10.1117/12.884665 ul-Haq E, Liu Z, Zhang Y, Alang Ahmad S, Wong L, Hobbs J, Leggett G, Micklefield J, Roberts C, Weaver J. The Snomipede: A Parallel Platform for Scanning Near-Field Photolithography. J. Mater. Res. 2011; 26: in press. eScholarID:141820 | DOI:10.1557/jmr.2011.370