李学臣 - 香港大学

个人简介

2018- Professor, HKU 2014-2018 Associate Professor, HKU 2009-2014 Assistant Professor, HKU 2007-2009 Postdoc, Memorial Sloan Kettering Cancer Center(Professor Samuel Danishefsky) 2004-2007 Ph.D, Harvard University (Professor Dan Kahne) 2000-2003 M.Sc, University of Alberta (Professor Ole Hindsgaul) 1995-1999 B.Sc, Nankai University Awards and Honors 2023 Contribution Award in Carbohydrate Chemistry, Chinese Chemical Society 2020 The Cathay Award, Chinese Peptide Society 2019 The Rao Makineni Lectureship Award, American Peptide Society 2017 Croucher Senior Research Fellowship, Croucher Foundation

研究领域

I. Method developing for Bio-macromolecules synthesis II. Medicinal Chemistry of Natural Products III. Function Definition of Macromolecules and their PTMs IV. Drug Development

近期论文

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Wu, X.; Sun, Z.; Li, X.*N,O-Benzylidene Acetal Dipeptides (NBDs) Enable the Synthesis of Difficult Peptides via a Kinked Backbone Strategy.Angew. Chem. Int. Ed. 2023, e202310624 Zhang, Y.; Yin, R.; Jiang, H.; Wang, C.; Wang, X.; Wang, D.; Zhang, K.; Yu, R.*; Li, X.*; Jiang, T.*Peptide stapling through site-directed conjugation of triazine moieties to the tyrosine residues of the peptide.Org. Lett. 2023, 25, 2248-2252 Chen, Q.; Liu, H.; Li, X.*The Essential Functions, Syntheses and Detection of Sialyl Lewis X on Glycoproteins.Exploration of Drug Science 2023, 1: 31–54 Cheung C. H. P.; Chong, T. H.; Wei, T.; Liu, H.; Li, X.*Enabling intermolecular OPA-amine-thiol three-component reactions for modular construction.Angew. Chem. Int. Ed. 2023, 62, e202217150 Sun, Z.; Wei, T.; Cao, Y.; Li, X.*Protocol for semisynthesis of serotonylated histone H3 by rapid protein desulfurization in tandem with native chemical ligation.STAR Protocols 2023, 4, 102042 Wu, H.; Tan, Y.; Ngai, W. L.; Li, X.Total synthesis of interleukine-2 via Tunable Backbone Modification strategy Chem. Sci. 2023, 14, 1582-1589. Guo, X.; Shen, B.; Liu, C.; Zhao, H.; Li, X.*; Yu, P.*; Li, P*Rational design and organocatalytic enantioselective [1+4]-annualations of MBH carbonates with modified enones.Org. Chem. Front. 2023, 10, 150-156. Ma, W.; Wu, H.; Liu, S.; Wei, T.; Li, X. D.; Liu, H.*; Li, X.*Chemical synthesis of proteins with base-labile posttranslational modifications enabled by a Boc-SPPS based general strategy towards peptide C-terminal salicylaldehyde esters.Angew. Chem. Int. Ed. 2023. (hot paper), 62, e202214053 Gong, H-R.; Hu, Y-F.; Li, X.; Yau, T.; Zhang, B-Z.; Huang, J*Non-neutralising Epitopes Shade Neutralising Epitopes against Omicron in a Multiple Epitope-based Vaccine ACS Infect. Dis. 2022, 8, 2586 Ngai, P.; Cheng, Lee, A. H.; Xu, J.; Wei, C. J. W., Liu, J.; Hu, M.; Sun, Z. Neelakatan, P.; Li, X.*; Zhang, C.*Effects of L-Chg10-teixobactin on viability, proliferation and osteo/odontogenic differentiation of stem cells from apical apilla.J. Endodonitics 2022, S0099-2399, 22, 00758-0. Wei, T.#; Li, D.#; Zhang, Y.#; Tang, Y.; Zhou, H.; Liu, H.*; Li, X.*Thiophene-2,3-dialdehyde enables chemoselective cyclization on unprotected peptides, proteins and phage displayed peptides.Small Methods 2022, 6, 2201164. (impact factor: 15.367) Sun, Z.; Ma, W.; Cao, Y.; Wei, T.; Chow, H.Y.; Tan, Y.; Cheung, C.H.P.; Liu, J.; Lee, H.K.; Liu, H.; Li, X.* Superfast Desulfurization for Protein Chemical Synthesis and Modification. Chem 2022. 144, 14748-14757 Wu, H.; Wei, Tong.; Ngai, W. L.; Zhou, H. Y.; Li, X.* Ligation Embedding Aggregation Disruptor Strategy Enables the Chemical Synthesis of PD-1 Immunoglobulin and Extracellular Domains. J. Am. Chem. Soc. 2022. 144, 14748-14757 Chow, H. Y.; Po, K. H. L.; Chen, S.; Li, X.* Studies on daptomycin lactam-based analogues. J. Pept. Sci. 2022. e3430 Liu, J.; Li, X.* Serine/Threonine ligation and Cysteine/Penicillamine ligation. Methods Mol. Biol. 2022. 2530, 33-43. Included in Chemical Protein Synthesis for Methods in Molecular Biology. Springer Nature 2022. Jarkhi, A.; Lee, A.H.C.; Sun, Z.; Hu, M.; Neelakantan, P.; Li, X.; Zhang, C.* Antimicrobial effects of L-Chg10-teixobactin against Enterococcus faecalis in vitro.Microorganisms 2022. 10, 1099. Jiang, H.; Zhang, Q.; Zhang, Y.; Feng, H.; Pu, F.; Yu, R.; Zhong, Z.; Wang, C.; Fung, Y. M. E.; Blasco, P.; Li, Y.; Jiang, T.*; Li, X.* Triazin-pyridine chemistry for selective tyrosine labelling of proteins. Chem. Commun. 2022. 58, 7066-7069. Liu, J.; Wei, T.; Tan, Y.; Li, X.* Enabling chemical protein (semi)synthesis via Reducible solubilizing tags (RST). Chem. Sci. 2022. 13, 1367. Cheung, C. H. P.; Chow, H. Y.; Li, C.; Chen, K.; Chen, S.; Li X.* Synthesis of daptomycin thiolactone analogue via the MeDbz-linker based cyclative-cleavage approach. Pep. Sci. 2022. 114, e24255 Li, X.* Long journey on daptomycin. Synlett 2022. 33, 27-33 Wang, J.; Li, X.* Complex natural product synthesis via Serine/Threonine ligation. Bioorg. Med. Chem. Lett. 2021. 43, 128430 Wei, R.; Yang, X.; Liu, H.; Wei, T.; Chen, S.*; Li, X.* Synthetic pseudaminic-acid-based antibacterial vaccines confers effective protection against Acinetobacter baumannii infection. ACS Cent. Sci. 2021. 7, 1535-1542 Wang, J.; Lin, D.; Liu, M.; Blasco, P.; Sun, Z.; Cheung, Y.C.; Chen, S.; Liu, H.; Li, X.* Total synthesis of mannopeptimycin β via β-Hydroxyenduracididine Ligation. J. Am. Chem. Soc. 2021. 143, 12784-12790 Sun, Z.; Li, X.* Studies on 2-formylphenylboronic acid-based Ser/Thr ligation and Cys/Pen ligation. Chin. J. Chem. 2021. 39, 2795-2800 Wei, T.; Liu, H.; Wu, H.; Fan, P.; Li, X.* Chemical synthesis of HMGA1a with site-specific PTMs for biochemistry study. STAR Protocols 2021. 2, 100777 Po, K. H. L.; Chow, H. Y.; Cheng, Q.; Deng, X.; Wang, S.; Chan, E. W. C.; Chan, K. F.; Li, X.*; Chen, S.* Daptomycin exerts bactericidal effect through induction of excessive ROS production and blocking the function of stress response protein Usp2. Natural Science 2021. 1:e10023 Unarta, I. C.; Xu, J.; Shang, Y.; Cheung, C. H. P.; Zhu, R.; Chen, X.; Cao, S.; Bierer, D.; Zhang, M.; Huang, X*; Li, X.* Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain. RSC Chem. Biol. 2021. 2, 1274-1284 Wu, H.; Zhang, Y.; Li, Y.; Xu, J.; Wang, Y.*; Li, X.* Chemical Synthesis and Biological Evaluation of Adiponectin Collagenous Domain Glycoforms. J. Am. Chem. Soc. 2021, 143, 7808-7818. Blasco, P.; Zhang, C.; Chow, H. Y.; Chen, G.; Wu, Y.; Li, X.* An atomic perspective on improving daptomycin’s activity. Biochim Biophys Acta Gen Subj. 2021, 1865, 129918. Zhang, B.Z., Wang, X., Yuan, S., Li, W., Dou, Y., Poon, V.K.M., Chan, C.C.S., Cai, J.P., Chik, K.K., Tang, K., Chan, C.C.Y., Hu, Y.F., Hu,J.C., Badea, S.R., Gong, H.R., Lin, X.S., Chu, H., Li, X., To, K.K., Liu, L., Chen, Z.W., Hung, I.F.N., Yuen, K.Y. A novel linker-immunodominant site (LIS) vaccine targeting the SARS-CoV-2 spike protein protects against severe COVID-19 in Syrian hamsters. Emerging Microbes & Infection 2021, 10, 874-884. Cheung, C.; Xu, J.; Lee, C. L.; Zhang, Y.; Wei, R.; Bierer, D.; Huang, X.; Li, X*Construction of diverse peptide structural architectures via chemical ligation. Chem. Sci. 2021, 12, 7091-7097.