黄钢锋 - 农业部沼气科学研究所 -

个人简介

2015-2019于德国马普陆地微生物研究所(Max Planck Institute for Terrestrial Microbiology)攻读博士学位及博士后研究，现就职于农业农村部沼气科学研究所微生物研究中心，课题组组长。

研究领域

主要从事厌氧微生物代谢途径功能酶(氢酶、烷基-辅酶M还原酶及厌氧烃降解酶)的研究，运用生化分析(酶动力学)、突变分析(定点突变)、结构分析(X-ray衍射晶体学)、谱学(红外光谱、电子顺磁共振、穆斯堡尔谱学)及计算化学(DFT、QM/MM)等技术手段阐释酶的结构、功能与催化机理，为理解代谢途径功能酶的生物学功能提供理论依据。在此基础上，结合有机小分子合成及合成生物学，构建具有高催化活性、高应用价值的人造酶及生物催化剂(artificial enzymes and bio-inspired catalysts)。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Huang G, Wagner T, Ermler U, Shima S. Methanogenesis involves direct hydride transfer from H2 to an organic substrate. Nature Reviews Chemistry 2020, https://doi.org/10.1038/s41570-020-0167-2 Huang G#, Wagner T#, Demmer U, Warkentin E, Ermler U, et al. The hydride transfer process in NADP dependent methylene-tetrahydromethanopterin dehydrogenase. Journal of Molecular Biology 2020, https://doi.org/10.1016/j.jmb.2020.01.042 Huang G#, Wagner T#, Wodrich MD, Ataka K, Bill E, et al. The atomic-resolution crystal structure of activated [Fe]-hydrogenase. Nature Catalysis 2019, 2, 537-543. https://doi.org/10.1038/s41929-019-0289-4 Pan HJ, Huang G, Wodrich MD, Tirani FF, Ataka K, et al. A catalytically active [Mn]-hydrogenase incorporating a non-native metal cofactor. Nature Chemistry 2019, 11, 669–675. https://doi.org/10.1038/s41557-019-0266-1 Wagner T#, Huang G#, Ermler U, Shima S. How [Fe]-hydrogenase from Methanothermobacter is protected against light and oxidative stress. Angew. Chem. Int. Ed. 2018, 57, 15056-15059. https://doi.org/10.1002/anie.201807203 Huang G, Wagner T, Ermler U, Bill E, Ataka K, et al. Dioxygen sensitivity of [Fe]- hydrogenase in the presence of reducing substrates. Angew. Chem. Int. Ed. 2018, 57, 4917-4920. https://doi.org/10.1002/anie.201712293