Nilsson, Mathias - The University of Manchester

个人简介

I obtained my BSc in Food Chemistry form the University of Kalmar, Sweden (1993), and subsequently my PhD in Food Science (supervised by Per Aman) from the Swedish University of Agricultural Sciences (1999), Uppsala Sweden. I later spent two years as a post doctoral research associate in Aveiro, Portugal (2002-2003), working in Food Science and NMR. In 2004 I moved to Manchester where I spent three years as a postdoctoral research associate. In 2007 I was awarded an EPSRC Advance Research Fellowship. 2012 I became Lecturer and 2013 Reader in Physical Chemistry. My current research interest includes the development and application of novel methods in liquids NMR spectroscopy.

研究领域

The focus of our research is the development and application of novel methods in liquids NMR spectroscopy. NMR is most commonly applied to relatively pure substances in solution, where it is unparalleled as a technique for extracting structural, chemical and physical information. The analysis of mixtures ,a large part of our work, is a particularly challenging area because it is often difficult to tell which NMR signals come from which molecular species. The most important current method for analysis of intact mixtures by NMR is diffusion-ordered spectroscopy (DOSY), where signals from different molecular species are differentiated by their diffusion behaviour (i.e. molecular size). When NMR signals are well separated, analysis of DOSY data is relatively straightforward, but when signals overlap (as is common) analysis is much more difficult. We are developing methods to deal with such overlapping data. The effects of overlap can be attacked both from the signal processing end and from the spectroscopy end of the problem; both these approaches form part of our current research. From the spectroscopy end, a reduction in overlap can be achieved either by reducing spectral complexity, as in pure shift DOSY, or by increasing the number of spectroscopic dimensions, as in the variety of 3D DOSY methods we have developed. From the signal processing end, covariance of the experimental data (e.g. the fact that all the signals from a particular species should show the same diffusion properties) can be taken advantage of by using multivariate methods for analysis. We are also looking at combining DOSY with other types of experiment to increase the resolving power in the diffusion dimension, as well as properties other than diffusion that may allow the signals from different chemical species to be separated.

近期论文

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L. Kaltschnee, A. Kolmer, I. Timári, V. Schmidts, R. W. Adams, M. Nilsson, K. E. Kövér, G. A. Morris and C. M. Thiele. "Perfecting" pure shift HSQC: full homodecoupling for accurate and precise determination of heteronuclear couplings. Chemical Communications. 2014 October; eScholarID:242670 Acar E, Papalexakis E, Gurdeniz G, Rasmussen M, Lawaetz A, Nilsson M, Bro R. Structure-revealing data fusion. Bmc Bioinformatics. 2014; 15: 17. eScholarID:248680 | DOI:10.1186/1471-2105-15-239 Acar E, Papalexakis E, Gurdeniz G, Rasmussen M, Lawaetz A, Nilsson M, Bro R. Structure-revealing data fusion. BMC bioinformatics. 2014; 15(1): 239-239. eScholarID:248676 | DOI:10.1186/1471-2105-15-239 Adams R, Byrne L, Kiraly P, Foroozandeh M, Paudel L, Nilsson M, Clayden J, Morris G. Diastereomeric ratio determination by high sensitivity band-selective pure shift NMR spectroscopy. Chemical Communications. 2014; 50(19): 2512-2514. eScholarID:248668 | DOI:10.1039/c3cc49659g Aguilar J, Adams R, Nilsson M, Morris G. Suppressing exchange effects in diffusion-ordered NMR spectroscopy. Journal of Magnetic Resonance. 2014; 238: 16-19. eScholarID:248682 | DOI:10.1016/j.jmr.2013.10.018 Bjorneras J, Botana A, Morris G, Nilsson M. Resolving complex mixtures: trilinear diffusion data. Journal of Biomolecular Nmr. 2014; 58(4): 251-257. eScholarID:248678 | DOI:10.1007/s10858-013-9752-8 Dal Poggetto G, Favaro D, Nilsson M, Morris G, Tormena C. F-19 DOSY NMR analysis for spin systems with (n)J(FF) couplings. Magnetic Resonance in Chemistry. 2014; 52(4): 172-177. eScholarID:248670 | DOI:10.1002/mrc.4047 Ebrahimi P, Nilsson M, Morris G, Jensen H, Engelsen S. Cleaning up NMR spectra with reference deconvolution for improving multivariate analysis of complex mixture spectra. Journal of Chemometrics. 2014; 28(8): 656-662. eScholarID:248671 | DOI:10.1002/cem.2607 Foroozandeh M, Adams R, Meharry N, Jeannerat D, Nilsson M, Morris G. Ultrahigh-Resolution NMR Spectroscopy. Angewandte Chemie-International Edition. 2014; 53(27): 6990-6992. eScholarID:248683 | DOI:10.1002/anie.201404111 Foroozandeh M, Adams R, Nilsson M, Morris G. Ultrahigh-Resolution Total Correlation NMR Spectroscopy. Journal of the American Chemical Society. 2014; 136(34): 11867-11869. eScholarID:248677 | DOI:10.1021/ja507201t Kaltschnee L, Kolmer A, Timari I, Schmidts V, Adams R, Nilsson M, Koever K, Morris G, Thiele C. "Perfecting'' pure shift HSQC: full homodecoupling for accurate and precise determination of heteronuclear couplings. Chemical Communications. 2014; 50(99): 15702-15705. eScholarID:248669 | DOI:10.1039/c4cc04217d Mikkelsen M, Cornali S, Jensen M, Nilsson M, Beeren S, Meier S. Probing Interactions between beta-Glucan and Bile Salts at Atomic Detail by H-1-C-13 NMR Assays. Journal of Agricultural and Food Chemistry. 2014; 62(47): 11472-11478. eScholarID:248675 Petersen B, Nilsson M, Bojstrup M, Hindsgaul O, Meier S. H-1 NMR spectroscopy for profiling complex carbohydrate mixtures in non-fractionated beer. Food Chemistry. 2014; 150: 65-72. eScholarID:248679 | DOI:10.1016/j.foodchem.2013.10.136 Timari I, Kaltschnee L, Kolmer A, Adams R, Nilsson M, Thiele C, Morris G, Kover K. Accurate determination of one-bond heteronuclear coupling constants with "pure shift" broadband proton-decoupled CLIP/CLAP-HSQC experiments. Journal of Magnetic Resonance. 2014; 239: 130-138. eScholarID:248673 | DOI:10.1016/j.jmr2013.10.023 Vieira M, Gramosa N, Ricardo N, Morris G, Adams R, Nilsson M. Natural product mixture analysis by matrix-assisted DOSY using Brij surfactants in mixed solvents. Rsc Advances. 2014; 4(79): 42029-42034. eScholarID:248681 | DOI:10.1039/c4ra04433a