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个人简介

Andrew Hutchins 博士毕业于英国东安格利亚大学,曾长时间任职于新加坡基因组研究所和日本大阪大学的免疫学前沿研究中心。在来南方科技大学之前,任职于中国科学院广州生物医药与健康研究院,进行多能干细胞重编程的分子障碍和重编程途径的研究,长期从事干细胞、转座子研究,细胞命运调控和转换研究,在生物信息学、计算基因组学、诱导多能干细胞和表观遗传学领域做出了系统与创新性工作。对于多能干细胞的研究有着丰富的经验,近5年来以第一作者或者合作作者身份,在Nature Communications,Cell Stem Cell,Nature Cell Biology,Nucleic Acids Research,Stem Cells,Blood, Cell Research等知名国际期刊发表文章40多篇学术论文。

研究领域

我们团队在hESCs 基础研究,hESCs 分化巨噬细胞,细胞重编程,先天性免疫细胞、转座子和细胞分化机制有着丰富的研究经验和研究成果,同时专注于下一代测序生物学数据的计算分析,以及基因组学、生物信息学分析等。

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Steffens, Simon, Xiuling Fu, Fangfang He, Yuhao Li, Isaac A. Babarinde, andAndrew P. Hutchins. "DPre: computational identification of differentiation bias and genes underlying cell type conversions." Bioinformatics (2019). Babarinde, Isaac A., Yuhao Li, and Andrew P. Hutchins. "Computational methods for mapping, assembly and quantification for coding and non-coding transcripts." Computational and structural biotechnology journal(2019). Vikas Malik, Laura V. Glaser, Dennis Zimmer, Sergiy Velychko, Mingxi Weng, Markus Holzner, Marius Arend, Yanpu Chen, Yogesh Srivastava, Veeramohan Veerapandian, Zahir Shah, Miguel A. Esteban, Huating Wang, Jiekai Chen, Hans R. Schöler, Andrew P. Hutchins, Sebastiaan H. Meijsing, Sebastian Pott & Ralf Jauch. "Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2." Nature communications10, no. 1 (2019): 1-16. He J, Fu X, Zhang M, He F, Li W, Abdul M, Zhou J, Sun L, Chang C, Li Y, Liu H, Wu K, Babarinde IA, Zhuang Q, Loh YH, Chen J, Esteban MA, Hutchins AP. (2019). Transposable elements are regulated by context-specific patterns of chromatin marks in mouse embryonic stem cells. Nature Communications. 10(1);34. Guo L, Lin L, Wang X, Gao M, Cao S, Mai Y, Wu F, Kuang J, Liu H, Yang J, Chu S, Song H, Li D, Liu Y, Wu K, Liu J, Wang J, Pang G,Hutchins AP, Liu J, Pei D, Chen J. (2019) Resolving Cell Fate Decisions during Somatic Cell Reprogramming by Single-Cell RNA-Seq. Mol Cell, 73(4)815-829. Li J, Huang K, Hu G, Babarinde IA, Li Y, Dong X, Chen Y, Shang L, Guo W, Wang J, Chen Z, Hutchins AP, Yang Y, Yao H. (2019) An alternative CTCF isoform antagonizes canonical CTCF occupancy and changes chromatin architecture to promote cell apoptosis. Nature Communications. Accepted. Zhuang Q*, Li W*, Benda C*, Huang Z, Ahmed T, Liu P, Guo X, Ibañez D, Luo Z, Zhang M, Abdul M, Yang Z, Yang J, Huang Y, Zhang H, Huang D, Zhou J, Zhong X, Zhu X, Fu X, Fan W, Liu Y, Xu Y, Ward C, Khan M, Kanwal S, Mirza B, Tortorella M, Tse HF, Chen J, Qin B, Bao X, Gao S, Hutchins AP#, Esteban MA#. (2018) NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming. Nature Cell Biology. 20(4):400-412. *Co-first, #Co-corresponding Yao M. Zhou X. Zhou J. Gong S. Hu G. Li J. Huang K. Lai P. Shi G. Hutchins AP. Sun H. Wang H. Yao H. (2018) PCGF5 is required for neural differentiation ofembryonic stem cells. Nature Communications. 9(1);1463 Bao X*, Guo X*, Yin M, Tariq M, Lai Y, Kanwal S, Zhou J, Li N, Lv Y, Pulido-Quetglas C, Wang X, Ji L, Khan M, Zhu X, Luo Z, Shao C, Lim D, Liu X, Li N, Wang W, He M, Liu Y, Ward C, Wang T, Zhang G, Wang D, Yang J, Chen Y, Zhang C, Jauch R, Yang Y, Wang Y, Qin B, Anko M, Hutchins AP, Sun H, Wang H, Fu X, Zhang B#. Esteban MA#. (2018) Capturing the Interactome of Newly Transcribed RNA. Nature Methods. 15(3)213-220. *Co-first, #Co-corresponding Li D*, Liu J*, Yang X*, Zhou C, Guo J, Wu C, Qin L, He J, Yu S, Liu H, Wang X, Wu F, Kuang J, Hutchins AP#, Chen J#, Pei D# (2017) Chromatin accessibility dynamics during iPSC reprogramming. Cell Stem Cell.21(6):819-833. *Co-first, #Co-corresponding Zhou Z, Yang Y, He J, Liu J, Wu F, Yu S, Liu Y, Lin R, Liu H, Cui Y, Wang X, Cao S, Guo L, Lin L, Wang T, Peng X, Hutchins AP, Pei D#, Chen J#. (2017) Kdm2b regulates somatic reprogramming through variant PRC1 complex dependent function. Cell Reports. 21(8):2160-2170. #Co-corresponding Fu X, He F, Li Y, Shahveranov A, Hutchins AP# (2017) Genomic and molecular control of cell type and cell type conversions. Cell Regeneration. 6:1. #Corresponding Hutchins AP#, Yang Z, Li Y, He F, Fu X, Wang X, Li D, Liu K, He J, Wang Y, Chen J, Esteban MA, Pei D#. (2017) Models of global gene expression define major domains of cell type and tissue identity. Nucleic Acids Research. 45(5):2354. #Co-corresponding Andrabi M, Hutchins AP, Miranda-Saavedra D, Kono H, Nussinov R, Mizugichi K, Ahmad S. (2017) Predicting conformational ensembles and genome-wide transcription factor binding from DNA sequences. Scientific Reports. 7(1):4071 Li Q*, Hutchins AP*, Chen Y, Li S, Shan Y, Liao B, Zheng D, Shi X, Li Y, Chan W, Pan G, Wei S, Shu X#, Pei D#. (2017) A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes. Nature Communications. 8:15166. *Co-first, #Co-corresponding Yang J*, Wang Y*, Zhou T, Wong L, Tian X, Hong X, Lai W, Au K, Wei R, Liu Y, Cheng L, Liang G, Huang Z, Fan W, Zhao P, Wang X, Ibanez DP, Luo Z, Li Y, Chen S, Wang D, Li L, Lai L, Qin B, Hutchins AP, Siu C, Huang Y, Esteban MA#, Tse H#. (2017) Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells. Stem Cell Reports. 8(3):605-618. *Co-first, #Co-corresponding Li H*, Lai P*, Jia J*, Song Y, Xia Q, Huang K, He N, Ping W, Chen J, Yang Z, Li J, Yao M, Gong X, Zhao J, Hou C, Esteban MA, Gao S, Pei D, Hutchins AP, Yao H. (2017) RNA Helicase DDX5 Inhibits Reprogramming to pluripotency by miRNA-based repression of RYBP and its PRC1-dependent and -independent Functions. Cell Stem Cell. 20(4):462 *Co-first authors Huang K*, Gao J*, Du J*, Ma N, Zhu Y, Wu P, Zhang T, Wang W, Li Y, Chen Q, Hutchins AP, Yang Z, Zheng Y, Shan Y, Li X, Liao B, Liu J, Wang J, Liu D, Pan G (2016) Generation and analysis of GATA2w/eGFP human ESCs reveal ITGB3/CD61 as a reliable marker for defining hemogenic endothelial cells during hematopoiesis. Stem Cell Reports. 7(5):854-868. *Co-first authors Pugacheva E, Teplyakov E, Wu Q, Li J, Chen C, Meng C, Liu J, Robinson S, Loukinov D, Hutchins AP, Boukaba A, Lobanenkov V, Strunnikov AV. (2016) The cancer-associated CTCFL/BORIS protein targets multiple classes of genomic repeats, with a distinct binding and functional preference for humanoid-specific SVA transposable elements. Epigenetics & Chromatin. 9(1):35 Xu Y, Zhang M, Li W, Zhu X, Bao X, Hutchins AP#, Esteban MA#. (2016) Transcriptional control of somatic cell reprogramming. Trends in Cell Biology. 26(4):272-88 #Co-corresponding

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