刘东 - 南方科技大学

个人简介

工作经历 2017-至今南方科技大学生物系，副教授 2008-2017 北京大学生命科学学院，研究员, 博士生导师 1999-2008 俄勒冈大学神经所，博士后转高级助研（senior research associate） 1990-1991 淡水生态学及生物技术国家重点实验室（中科院武汉水生所），助研（research assistant）教育背景 1999-2004 俄勒冈大学神经所，发育生物学博士后 1992-1999 多伦多大学生化系，分子内分泌学硕士、博士（PhD，哲学博士） 1987-1990 中国科学院水生生物研究所，遗传学硕士 1983-1987 武汉大学生物系，理学学士

研究领域

1. 斑马鱼内耳（外周神经系统器官）的发育机制 2. 斑马鱼侧线毛细胞损伤/再生机制 3. 构建人类神经性疾病的斑马鱼模型，并进行治疗性先导化合物的筛选，靶标确定及作用机理研究 4. 基因组编辑技术研发

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Sun P, Zhang Y, Zhao F, Wu J-P, Pun SH, Peng C, Du M, Vai MI, Liu D*, Chen F*. (2018). An Assay for Systematically Quantifying the Vestibulo-Ocular Reflex to Assess Vestibular Function in Zebrafish Larvae. Front Cell Neurosci, doi:10.3389/fncel.2018.00257 Li X, Song G, Zhao Y, Zhao F, Liu C, Liu D*, Li Q*, Cui Z*. (2017). Claudin7b is required for the formation and function of inner ear in zebrafish. J Cell Physiol, doi: 10.1002/jcp.26162 Yang L, Chang S, Lu Q, Zhang Y, Wu Z, Sun X, Cao Q, Qian Y, Jia T, Xu B, Duan Q, Li Y., Zhang K, Schumann G, Liu D*, Wang J*, Wang Y*, Lu L. (2017). A new locus regulating MICALL2 expression was identified for association with executive inhibition in children with attention deficit hyperactivity disorder. Mol Psychiatry, doi:10.1038/mp.2017.74 张汀樾等(2017). 绝经前后女性听力变化相关因素分析. 中国妇产科临床杂志, 2017(4):324-327 Gao H, Bu Y, Wu Q, Wang X, Chang N, Lei L, Chen S, Liu D, Zhu X, Hu K, Xiong J. (2015). Mecp2 regulates neural cell differentiation by suppressing the Id1-Her2/Hes5 axis in zebrafish. J Cell Sci, 128(12):2340-2350. Long L, Guo H, Yao D, Xiong K, Li Y, Liu P*, Zhu Z, Liu D*. (2015). Regulation of transcriptionally active genes via the catalytically inactive Cas9 in elegansand rerio. Cell Res, 25:638-641. Wang J, Zhao F, Wu Y, Wu YT, Yao D, Dong W, Zhao J, Zhu Z, Liu D*. (2015). Fgf signaling dependent Sox9a and Atoh1a regulate otic neural development in zebrafish. J Neurosci, 35:234-244 (one of two highlighted article of the issue). Yao D, Zhao F, Wu Y, Wang J, Zhao J, Zhu Z, Liu D*. (2014). Dissecting the differentiation process of the pre-placodal ectoderm in zebrafish. Dev Dyn, 243:1328-1337. Liu P, Long L, Xiong K, Yu B, Chang N, Xiong J-W, Zhu Z, Liu D*. (2014). Heritable/Conditional Genome Editing inelegansusing a CRISPR-Cas9 Feeding System. Cell Res, 24:886-889. Sheehan-Rooney K, Swartz ME, Zhao F, Liu D, Eberhart JK. (2013). Ahsa1 and Hsp90 activity confers more severe craniofacial phenotypes in a zebrafish model of hypoparathyroidism, sensorineural deafness and renal dysplasia (HDR). Dis Model Mech, 6(5):1285-1291. Li H, Huang P, Dong W, Zhu Z and Liu D*. (2013). A brief history of zebrafish research-toward biomedicine. Hereditas (Beijing), 35(4): 410-420 (in Chinese). Dong W, Yang Z, Yang F, Wang J, Zhuang Y, Xu C, Zhang B, Tian X*, Liu D*. (2012). Suppression of Rap1 impairs cardiac myofibril and conduction system in zebrafish. PLoS ONE, 7(11): e50960. Doi:10.1371/journal.pone.0050960. Liu M, Liu P, Zhang L, Gao G, Zhang W, Zhu Z, Liu D*, Fan Q*. (2011). mir-35 is involved in control of intestine cell G1/S transition and germ cell proliferation in C. elegans. Cell Res, 21(11):1605-1618. Choy SW, Cheng CW, Lee ST, Li VWT, Hui MNY, Hui C, Liu D, Cheng SH. (2010). A cascade of irx1a and irx2a controls shh expression during retinogenesis. Dev Dyn, 239:3204-3214. Shen YC, Jeyabalan AK, Wu KL, Hunker KL, Kohrman DC, Thompson DL, Liu D and Barald KF. (2008). The transmembrane inner ear (time) gene contributes to vestibular and lateral line development and function in the Zebrafish (Danio rerio). Dev Dyn, 237(4):941-952. Rotllant J, Liu D, Yan Y-L, Postlethwait JP, Westerfield M, Du SJ. (2008). SPARC (Osteonectin) functions in morphogenesis of the pharyngeal skeleton and inner ear. Matrix Biol 27(6):561-572. Hans S, Christison J, LIU D, Westerfield M. (2007). Fgf-dependent otic induction requires competence provided by FoxiI and Dlx3b. BMC Dev Biol, 7(1):5. Doi:10.1186/1471-213X-7-5. Liu D, Yan Y_L, Hans S, Westerfield M. (2006). Sox9 genes mediate Fgf-dependent otic induction. Dev Biol, 295(1):385-386. Yan Y-L, Willoughby J, Liu D, Crump JG, Wilson C, Miller CT, Singer A, Kimmel C, Westerfield M, Postlethwait JH. (2005). A pair of Sox: distinct and overlapping functions of zebrafish Sox9 co-orthologs in craniofacial and pectoral fin development. Development, 132: 1069-1083. Hans S, Liu D, Westerfield M. (2004). Pax8 and Pax2a function synergistically in otic specification, downstream of the Foxi1 and Dlx3b transcription factors. Development, 131: 5091-5102. Liu D, Chu H, Maves L, Yan YL, Morcos PA, Postlethwait JH, Westerfield M. (2003). Fgf3 and Fgf8 dependent and independent transcription factors are required for otic placode specification. Development, 130: 2213-2224. Yan Y-L, Miller CT, Nissen R, Singer A, Liu D, Kirn A, Draper B, Willoughby J, Morcos PA, Amsterdam A, Chung B, Westerfield M, Haffter P, Hopkins N, Kimmel C and Postlethwait JH. (2002). Zebrafish sox9gene required for cartilage morphogenesis. Development, 129: 5065-5079. Liu D, Chandy M, Lee SK, Le Dréan Y, Ando H, Xiong F, Woon Lee J, Hew CL. (2000). A zebrafish ftz-F1 (Fushi tarazu factor 1) homologue requires multiple subdomains in the D and E regions for its transcriptional activity. J Biol Chem, 2;275(22):16758-16766.