个人简介
工作经历
2013～今，副教授，南方科技大学
2008～2013，研究助理教授，香港大学生理系
2004～2008，博士后，美国哈佛医学院Dana-Farber Cancer Institute
学习经历
1999～2004, 生物学博士，中国科学技术大学生命科学学院
1995～1999，生命科学学士，中国科学技术大学生命科学学院
研究领域
实验室主要以X-射线晶体学手段进行结构生物学研究。这一研究包括目标蛋白的表达和纯化，蛋白晶体的筛选和优化，X-射线衍射数据的收集，相角测定，模型搭建以及结构修正和分析。结构生物学研究为解释生命现象、功能预测和药物研发奠定坚实的结构基础
近期论文
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（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）
1.Protein-complex structure completion using IPCAS (Iterative Protein
Crystal structure Automatic Solution)，Weizhe Zhang, Hongmin Zhang, Tao Zhang, Haifu Fan and Quan Hao，2015，Acta Cryst. D71, 1487–1492
2.“Anion clamp” allows flexible protein to impose coordination geometry on metal ions. M Wang, TP Lai, L Wang, H Zhang, N Yang, PJ Sadler, H Sun, Chemical Communications 2015, 51 (37), 7867-7870
3.Cyclic Adenosine 5′-Diphosphate Ribose Analogs without a “Southern” Ribose Inhibit ADP-ribosyl Cyclase-Hydrolase CD38. Swarbrick JM, Graeff R, Zhang H, Thomas MP, Hao Q, Potter BV. J Med Chem. 2014 Oct 1.
Crystallographic phasing with NMR models: an envelope approach. Zhang W, Zhang T, Zhang H, Hao Q. Acta Crystallogr D Biol Crystallogr. 2014 Jul;70(Pt 7):1977-82.
4.Hongmin Zhang, Richard Graeff, Hon Cheung Lee, and Quan Hao (2013) Crystal Structures of Human CD38 in Complex with NAADP and ADPRP Messenger Vol. 2, 44-53
5.Nan Yang, Hongmin Zhang, Minji Wang, Quan Hao and hongzhe Sun (2012) Iron and bismuth bound human serum transferrin reveals a partially-opened conformation in the N-lobe. Scientific Report , 2:999. doi: 10.1038/srep00999. Epub 2012 Dec 19
6.Kwong, A. K.; Chen, Z.; Zhang, H.; et al. (2012) Catalysis-based inhibitors of the calcium signaling function of CD38. Biochemistry Volume: 51 Issue: 1 Pages: 555-64 (co-first)
7.Zhang, H.; Wang, J. H. (2012) Protein expression and purification of integrin I domains and IgSF ligands for crystallography. Methods Mol Biol Volume: 757 Pages: 101-10 (corresponding)
8.Ng, A. K.; Lam, M. K.; Zhang, H.; et al. (2012) Structural basis for RNA-binding and homo-oligomer formation by influenza B virus nucleoprotein. J Virol 86(12): 6758-67
9.Zhou, Y.; Zhang, H.; He, B.; et al. (2012) The Bicyclic Intermediate Structure Provides Insights into the Desuccinylation Mechanism of Human Sirtuin 5 (SIRT5) J Biol Chem Volume: 287 Issue: 34 Pages: 28307-14
10.Zhou, B.; Chen, Q.; Mallis, R. J.; Zhang, H.; et al. (2011) A Conserved Hydrophobic Patch on Vβ Domains Revealed by TCRβ Chain Crystal Structures: Implications for Pre-TCR Dimerization. Front Immunol Volume: 2 Pages: 5
11.Zhang H, Hao Q. (2011) Crystal structure of NDM-1 reveals a common {beta}-lactam hydrolysis mechanism. FASEB J. Volume: 25 Issue: 8 Pages: 2574-2582 (co-corresponding)
12.Zhao YJ, Zhang HM, Lam CM, Hao Q, Lee HC. (2011) Cytosolic CD38 protein forms intact disulfides and is active in elevating intracellular cyclic adp-ribose. J Biol Chem. 286(25):22170-7.
13.Zhang H, Graeff R, Chen Z, Zhang L, Zhang L, Lee H, Hao Q. (2011) Dynamic conformations of the CD38-mediated NAD cyclization captured in a single crystal. J Mol Biol. 405(4):1070-8.
14.Zhang H, Liu JH, Yang W, Springer T, Shimaoka M, Wang JH. (2009) Structural basis of activation-dependent binding of ligand-mimetic antibody AL-57 to integrin LFA-1. Proc Natl Acad Sci U S A. 106(43):18345-50.
15.Zhang H, Astrof NS, Liu JH, Wang JH, Shimaoka M. (2009) Crystal structure of isoflurane bound to integrin LFA-1 supports a unified mechanism of volatile anesthetic action in the immune and central nervous systems. FASEB J. 23(8):2735-40.
16.Zhang H, Casasnovas JM, Jin M, Liu JH, Gahmberg CG, Springer TA, Wang JH. (2008) An unusual allosteric mobility of the C-terminal helix of a high-affinity alpha L integrin I domain variant bound to ICAM-5. Mol. Cell. 31(3):432-7.
17.Ng AK, Zhang H, Tan K, Li Z, Liu JH, Chan PK, Li SM, Chan WY, Au SW, Joachimiak A, Walz T, Wang JH, Shaw PC. (2008) Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design. FASEB J. 22(10):3638-47.
18.Sun JS, Zhang QR, Zhang TY, Zhu ZL, Zhang HM, Teng MK, Niu LW, Xu WH (2005) Developmental expression of FXPRLamide neuropeptides in peptidergic neurosecretory cells of diapause- and nondiapause-destined individuals of the cotton bollworm, Helicoverpa armigera, Gen Comp Endocrinol. 141(1): 48-57.
19.Zhang H, Yang Q, Sun M, Teng M, Niu L. (2004) Hydrogen peroxide produced by two amino acid oxidases mediates antibacterial actions. J. Microbiol. 42(4):336-9.
20.Zhang H, Teng M, Niu L, Wang Y, Wang Y, Liu Q, Huang Q, Hao Q, Dong Y, Liu P. (2004) Purification, partial characterization, crystallization and structural determination of AHP-LAAO, a novel L-amino-acid oxidase with cell apoptosis-inducing activity from Agkistrodon halys pallas venom. Acta Crystallogr D Biol Crystallogr. 60(Pt 5):974-7
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