Heath, Sarah - The University of Manchester

个人简介

BSc. University of Kent at Canterbury 1989, PhD University of East Anglia 1992, Research Fellow University of East Anglia 1993, HCM Fellow, University of Trieste, Italy 1994, Temporary Lecturer, University of Newcastle-Upon-Tyne 1995, Royal Society URF and Lecturer, University of Sheffield 1996-1999, Royal Society URF and Lecturer, University of York 1999-2002 Senior Lecturer, University of Manchester 2002 - 2005 Reader, University of Manchester 2005 -

研究领域

1. 5f coordination chemistry We are interested in the behaviour in aqueous solution of the actinide ions. Our previous work with lewis acidic transition metal ions has shown that it is possible to control the hydrolysis products of these metals in the presence of chelating organic ligands by carefully controlling the pH of the system. The same principles should apply to the chemistry of the actinide ions as they too are lewis acidic. Therefore we hypothesize that we can control the hydrolysis products of the actinide ions in the presence of chelating organic ligands by careful control of pH and conversely we will be able to predict the types of actinide hydrolysis products that will form under specific pH conditions depending on the types of ligands present. Such chemistry has obvious implications for understanding the behaviour of the waste in the high pH storage ponds in sites. This chemistry could also be applied to understanding and controlling the chemistry of effluent waste. . 2. 4f coordination chemistry There is intense interest in the synthesis of non-radioactive reagents for use as labels for macromolecules in biotechnology applications. This work is driven by the fact that many of the radio-labels used presently have high costs and hazards, short lived half lives and intrinsically limited sensitivity. One of our aims in this area is to develop new lanthanide labels, which are easier to synthesise than their polypyridyl/imidazole and macrocyclic counterparts, are easily functionalised with linkers for attachment to biomolecules. The structure on the left shows an example of a dinuclear terbium complex we have synthesized which exhibits long-lived fluorescence lifetimes. We are also interested in the synthesis of lanthanide cluster species, such materials may find future applications in magnetic storage, imaging and future energy applications.

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C. May, L. Young, P. Worsfold, S. Heath, N. Bryan, M. Keith-Roach. The effect of EDTA on the groundwater transport of thorium through sand. Water Research. 2012 October; 46(15): 4870-4882. eScholarID:171808 | DOI:10.1016/j.watres.2012.06.012 Natrajan, Louise S.; Khoabane, Ntai M.; Dadds, Benjamin L.; Muryn, Christopher A.; Pritchard, Robin G.; Heath, Sarah L.; Kenwright, Alan M.; Kuprov, Ilya; Faulkner, Stephen. Probing the Structure, Conformation, and Stereochemical Exchange in a Family of Lanthanide Complexes Derived from Tetrapyridyl-Appended Cyclen. Inorganic Chemistry. 2010; 49(17): 7700-7709. eScholarID:112080 | DOI:10.1021/ic100447m Natrajan L, Timmins P, Lunn M, Heath S. Luminescent dinuclear lanthanide complexes of 5-Me-HXTA. Inorganic Chemistry. 2007 December; 46(25): 10877-10886. eScholarID:1f618 | DOI:10.1021/ic701366f Wood N, Brannigan J, Duckett S, Heath S, Wagstafft J. Detection of picomole amounts of biological substrates by para-hydrogen-enhanced NMR methods in conjunction with a suitable receptor complex. Journal of the American Chemical Society. 2007 September; 129(36): 11012-+. eScholarID:1f533 | DOI:10.1021/ja074286k HEATH SL; JIM A. THOMAS; H. M. MEIJER; PAUL DE WOLF; . Self-Assembled, Kinetically Locked, RuII-Based Metallomacrocyles: Physical, Structural, and Modeling Studies. Chemistry: A European Journal. 2005 December; 12(8): 2188-2195. eScholarID:1a10612 | DOI:10.1002/chem.200500623