Greaney, Michael - The University of Manchester

个人简介

Michael Greaney took his MChem degree at Oxford, then moved to London to carry out PhD work with William Motherwell FRS at UCL, completing his thesis in the area of new fluorinating agents in 2000. Following postdoctoral research with Jeffrey Winkler at the University of Pennsylvania, working on the total synthesis of ingenol, he returned to the UK to a lectureship position at the University of Edinburgh in 2002. He moved to his current position as Professor of Organic Chemistry at the University of Manchester in 2011.

研究领域

The Greaney group works in organic chemistry, developing new methods that enable faster, cleaner and better synthesis. Principal research themes are: 1) Metal-free arylation strategies; 2) Transition metal catalysed C-H activation and 3) Chemicobiological catalysis for new transformations in synthesis.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Aminoarylation of Alkynes using Diarylanilines Greaney, M. & Liu, Z., 22 May 2024, (E-pub ahead of print) In: Chemical Communications. Cascade Aryne Aminoarylation for Biaryl Phenol Synthesis Das, A., Myers, D. L., Ganesh, V. & Greaney, M., 15 Mar 2024, (Accepted/In press) In: Organic Letters. Regiodivergent Arylation of Pyridines via Zincke Intermediates Wang, H. & Greaney, M. F., 11 Jan 2024, (E-pub ahead of print) In: Angewandte Chemie International Edition. Synthesis of benzenes from pyridines via N to C switch Conboy, A. & Greaney, M. F., 5 Jun 2024, (E-pub ahead of print) In: Chem. An NHC-Catalyzed Desulfonylative Smiles Rearrangement of Pyrrole and Indole Carboxaldehydes Swaby, C., Taylor, A. & Greaney, M., 17 Aug 2023, In: The Journal of organic chemistry. Aryne-Enabled C-N Arylation of Anilines Sephton, T., Charitou, A., Trujillo Del Valle, C., Large, J. M., Butterworth, S. & Greaney, M., 4 Dec 2023, In: Angewandte Chemie. International Edition. 62, 49, 7 p., e202310583. Synthesis of Functionalized Pyrrolidinone Scaffolds via Smiles-Truce Cascade Sephton, T., Large, J. M., Butterworth, S. & Greaney, M. F., 5 Sept 2023, (E-pub ahead of print) In: Organic Letters. Chemoselective cascade arylation Wu, T. & Greaney, M. F., 10 Mar 2022, In: Chem. 8, 3, p. 609-611 Diarylamine Synthesis via Desulfinylative Smiles Rearrangement Sephton, T., Large, J. M., Butterworth, S. & Greaney, M. F., 30 Jan 2022, In: Organic Letters. NHC Catalysis for Umpolung Pyridinium Alkylation via deoxy‐Breslow Intermediates Wu, T., Tatton, M. R. & Greaney, M., 1 Feb 2022, In: Angewandte Chemie International Edition. Integrated Electro‐Biocatalysis for Amine Alkylation with Alcohols Greaney, M., Turner, N., Dryfe, R. & Penafiel, I., 2021, In: ChemCatChem. 13, 3, p. 864-867 4 p. Programmable late-stage C−H bond functionalization enabled by integration of enzymes with chemocatalysis Craven, E. J., Latham, J., Shepherd, S. A., Khan, I., Diaz-Rodriguez, A., Greaney, M. F. & Micklefield, J., May 2021, In: Nature Catalysis. 4, 5, p. 385-394 10 p. Recent Advances in The Smiles Rearrangement: New Opportunities for Arylation Whalley, D. M. & Greaney, M. F., 1 Dec 2021, In: Synthesis. Truce–Smiles Rearrangements by Strain Release: Harnessing Primary Alkyl Radicals for Metal-Free Arylation Whalley, D. M., Seayad, J. & Greaney, M., 4 Oct 2021, In: Angewandte Chemie International Edition. 60, 41, p. 22219-22223 5 p. Arylation and Alkenylation of Activated Alkyl Halides using Sulfonamides Greaney, M., Johnson, S. & Kovács, E., 14 Mar 2020, In: Chemical Communications. 56, 21, p. 3222-3224 3 p. A Visible Light-Mediated, Decarboxylative, Desulfonylative Smiles Rearrangement for General Arylethylamine Syntheses Whalley, D. M., Duong, H. A. & Greaney, M., 4 Oct 2020, In: Chemical Communications. 56, 77, p. 11493-11496 4 p. ortho C-H Arylation of Arenes at Room Temperature Using Visible Light Ruthenium C-H Activation Arunachalam, S., Charitou, A., Wang, F., Ivanova, M., Vuagnat, M. & Greaney, M., 7 May 2020, In: Chemical Science. 11, 17, p. 4439-4443 5 p. α-Fluorination of Nitrobenzenes and Nitropyridines via Vicarious Nucleophilic Substitution of Hydrogen Al-mkhaizim, F. Y. & Greaney, M. F., 1 Jul 2020, In: SYNLETT. 31, 11, p. 1094-1096 3 p. Alkene Carboarylation via Catalyst‐Free, Visible Light‐Mediated Smiles Rearrangement. Whalley, D., Duong, H. & Greaney, M., 2019, In: Chemistry – A European Journal. 25, p. 1927-1930 Arylation Using Sulfonamides: Phenylacetamide Synthesis through Tandem Acylation–Smiles Rearrangement Barlow, H. L., Rabet, P. T. G., Durie, A., Evans, T. & Greaney, M. F., 1 Nov 2019, In: Organic Letters. p. 9033-9035 meta-Selective C−H Activation of Arenes at Room Temperature Using Visible Light: Dual-Function Ruthenium Catalysis Sagadevan, A. & Greaney, M. F., 2019, In: Angewandte Chemie International Edition. 58, p. 9826-9830 Concurrent Biocatalytic Oxidation and C–C Bond Formation via Gold Catalysis: One-Pot Alkynylation of N-Alkyl Tetrahydroisoquinolines Odachowski, M., Greaney, M. F. & Turner, N. J., 2 Nov 2018, In: ACS Catalysis. 8, 11, p. 10032-10035 An Engineered Tryptophan Synthase Opens New Enzymatic Pathways to β-Methyltryptophan and Derivatives. Francis, D., Winn, M., Latham, J., Greaney, M. & Micklefield, J., 20 Jan 2017, In: ChemBioChem: a European journal of chemical biology . 18, 4, p. 382-386 5 p. Domino N- / C-arylation via in situ generation of a directing group: Atom efficient arylation using diaryliodonium salts Teskey, C., Sohel, S. M. A., Bunting, D., Modha, S. & Greaney, M., 2017, In: Angewandte Chemie - International Edition. 56, 19, p. 5263–5266 Metal-free intermolecular aminoarylation of alkynes Rabet, P., Boyd, S. & Greaney, M., 3 Apr 2017, In: Angewandte Chemie - International Edition. 56, 15, p. 4183–4186 4 p. Modern Aspects of the Smiles Rearrangement Holden, C. & Greaney, M., 2017, In: Chemistry: A European Journal. 23, p. 8992–9008 RadH a Versatile Halogenase for Integration into Synthetic Pathways. Menon, B., Brandenburger, E., Sharif, H., Klemstein, U., Shepherd, S., Greaney, M. & Micklefield, J., 15 Sept 2017, In: Angewandte Chemie. 56, 39, p. 11841-11845 4 p. Ruthenium Catalyzed meta-Carboxylation Barlow, H., Teskey, C. & Greaney, M., 2017, In: Organic Letters. Synthesis of Triarylamines via Sequential C−N Bond Formation Modha, S., Popescu, M. & Greaney, M., 17 Nov 2017, In: The Journal of organic chemistry. 82, p. 11933–11938 Benzylic C-H Azidation Using the Zhdankin Reagent and a Copper Photoredox Catalyst Rabet, P., Fumagalli, G., Boyd, S. & Greaney, M., 2016, In: Organic Letters. 18, 7, p. 1646-1649 4 p. Copper catalysis in a blue light Greaney, M., 12 Feb 2016, In: Science. 351, p. 666 Integrated catalysis opens new arylation pathways via regiodivergent enzymatic C-H activation Latham, J., Henry, J-M., Sharif, H., Menon, B., Shepherd, S., Greaney, M. & Micklefield, J., 10 Jun 2016, In: Nature Communications. 7, 11873. Metal Free Bi-(hetero)aryl Synthesis via Benzyne Truce-Smiles Rearrangement Greaney, M. F., Holden, C. M. & Sohel, S. A. M., 13 Jan 2016, In: Angewandte Chemie (International Edition). 55, p. 2450-2453 Structure and biocatalytic scope of thermophilic flavin-dependent halogenase and flavin reductase enzymes Menon, B., Latham, J., Dunstan, M., Brandenburger, E., Klemstein, U., Leys, D., Karthikeyan, C. V., Greaney, M., Shepherd, S. & Micklefield, J., 6 Sept 2016, In: Organic and Biomolecular Chemistry. 14, p. 9354-9361 Synthesis of biaryls using aryne intermediates Greaney, M. & Garcia-Lopez, J-A., 2016, In: Chemical Society Reviews. 45, p. 6766-6798 The Cross-Dehydrogenative-Coupling of Alkoxybenzenes with Toluenes: Copper(II) Halide Mediated Tandem Halo/Benzylation of Arenes Storr, T., Teskey, C. & Greaney, M., 12 Dec 2016, In: Chem.Eur. J.. 22, 50, p. 18169-18178