Greaney, Michael - The University of Manchester

个人简介

Michael Greaney took his undergraduate degree at Oxford, completing his part II research project in the group of Sir Jack Baldwin in 1996. He then moved to London to carry out PhD work with William Motherwell at UCL, completing his thesis in the area of new fluorinating agents in 1999. He then left the UK on a GlaxoWellcome scholarship to take up a postdoctoral position with Jeffrey Winkler at the University of Pennsylvania, where he worked on the total synthesis of the tumour-promoting diterpene ingenol. He returned to the UK in early 2002, to a lectureship position at the University of Edinburgh. He was awarded an EPSRC Leadership Fellowship in 2008, and in 2011 moved to the University of Manchester to a personal chair in organic chemistry.

研究领域

The Greaney group works in organic chemistry, developing new methods that enable faster, cleaner and better synthesis. Principal research themes are: 1) Capturing the benzyne reactive intermediate for arene synthesis; 2) Transition metal catalysed C-H activation; 3) Tandem reactions for natural product synthesis; 4) Dynamic covalent chemistry in chemical biology.

近期论文

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An Engineered Tryptophan Synthase Opens New Enzymatic Pathways to β-Methyltryptophan and Derivatives. Francis, D., Winn, M., Latham, J., Greaney, M. & Micklefield, J. 20 Jan 2017 In : ChemBioChem: a European journal of chemical biology . Domino N- / C-arylation via in situ generation of a directing group: Atom efficient arylation using diaryliodonium salts Teskey, C., Sohel, S. M. A., Bunting, D., Modha, S. & Greaney, M. 2017 In : Angewandte Chemie - International Edition. 56, 19 Metal-free intermolecular aminoarylation of alkynes Rabet, P., Boyd, S. & Greaney, M. 2017 In : Angewandte Chemie - International Edition. 56, p. 4183–4186 Structure and biocatalytic scope of thermophilic flavin-dependent halogenase and flavin reductase enzymes Menon, B., Latham, J., Dunstan, M., Brandenburger, E., Klemstein, U., Leys, D., Karthikeyan, C. V., Greaney, M., Shepherd, S. & Micklefield, J. 6 Sep 2016 In : Organic and Biomolecular Chemistry. 14, p. 9354-9361 Integrated catalysis opens new arylation pathways via regiodivergent enzymatic C-H activation Latham, J., Henry, J-M., Sharif, H., Menon, B., Shepherd, S., Greaney, M. & Micklefield, J. 10 Jun 2016 In : Nature communications. 7, 11873 Copper catalysis in a blue light Greaney, M. 12 Feb 2016 In : Science. 351, p. 666 Metal Free Bi-(hetero)aryl Synthesis via Benzyne Truce-Smiles Rearrangement Greaney, M. F., Holden, C. M. & Sohel, S. A. M. 13 Jan 2016 In : Angewandte Chemie (International Edition). 55, p. 2450-2453 Benzylic C-H Azidation Using the Zhdankin Reagent and a Copper Photoredox Catalyst Rabet, P., Fumagalli, G., Boyd, S. & Greaney, M. 2016 In : Organic Letters. 18, 7, p. 1646-1649 4 p. Synthesis of biaryls using aryne intermediates Greaney, M. & Garcia-Lopez, J-A. 2016 In : Chemical Society Reviews. 45, p. 6766-6798 The Cross-Dehydrogenative-Coupling of Alkoxybenzenes with Toluenes: Copper(II) Halide Mediated Tandem Halo/Benzylation of Arenes Storr, T., Teskey, C. & Greaney, M. 2016 In : Chem.Eur. J.. 22, 50, p. 18169-18178