Goodrich, James A. - University of Colorado - Chemistry and Biochemistry

个人简介

Ph.D.: Carnegie Mellon University, 1992 Postdoctoral Fellow: University of California at Berkeley, 1992-1996 Awards: Damon Runyon-Walter Winchell Cancer Fund, 1992-1994; Leukemia Society Special Fellow, 1995-1998; Pew Scholar in the Biomedical Sciences, 1999-2003

研究领域

Cell Signaling Molecular Biophysics Nucleic Acids Proteins & Enzymology Kinetics/Thermochemistry

近期论文

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Ponicsan, S.L., Houel, S., Old, W.M., Ahn, N.G., Goodrich, J.A., Kugel, J.F. (2013). The non-coding B2 RNA binds to the DNA cleft and active site region of RNA polymerase II. J. Mol. Biol. Epub ahead of print. Wagner, S.D., Yakovchuk, P., Gilman, B., Poniscan, S.L., Drullinger, L.F., Kugel, J.F., Goodrich, J.A. (2013). Mammalian RNA polymerase II acts as an RNA-dependent RNA polymerase to extend and destabilize a non-coding RNA. EMBO J. Epub ahead of print. Kassube, S.A., Fang, J., Grob, P., Yakovchuk, P., Goodrich, J.A., Nogales, E. (2012). Structural insights into transcriptional repression by ncRNAs that bind to human Pol II. J. Mol. Biol. Epub ahead of print. Blair, R.H. Goodrich, J.A., and Kugel, J.F. (2012). Single molecule FRET shows uniformity in TBP-induced DNA bending and heterogeneity in bending kinetics. Biochemistry. 51: 7444-7455. Dridi, S., Hirano, Y., Tarallo, V., Kim, Y., Fowler, B.J., Ambati, B.K., Bogdanovich, S., Chiodo, V.A., Hauswirth, W.W., Kugel, J.F., Goodrich, J.A., Ponicsan, S.L., Hinton, D.R., Kleinman, M.E., Baffi, J., Gelfand, B.D., and Ambati, J. (2012). ERK1/2 activation is a therapeutic target in age-related macular degeneration. Proc. Natl. Acad. Sci. USA. 109:13781-13786. Tarallo, V., Hirano, Y., Gelfand, B.D., Dridi, S., Kim, Y., Kerur, N., Cho, W.G., Kaneko, H., Fowler, B.J., Bogdanovich, S., Albuquerque, R.J.C., Hauswirth, W.W., Chiodo, V.A., Kugel, J.F., Goodrich, J.A., Ponicsan, S.L., Chaudhuri, G., Dunaief, J., Ambati, B.K., Ogura, Y., Yoo, J.W., Lee, D.-K., Provost, P., Hinton, D.R., Nú?ez, G., Baffi, J., Kleinman, M.E., and Ambati, J. (2012). DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell. 149:847-859. Kaneko, H., Dridi, S., Tarallo, V., Fowler, B.J., Gelfand, B.D., Cho, W.G., Kleinman, M.E., Ponicsan, S.L., Hauswirth, W.H., Chiodo, V.A., Karikó, K., Yoo, J.W., Lee, D.-K., Hadziahmetovic, M., Song, Y., Chaudhuri, G., Buaas, F.W., Braun, R.E., Hinton, D.R., Zhang, Q., Grossniklaus, H.E., Provis, J.M., Madigan, M.C., Milam, A.H., Justice, N.L., Albuquerque, R.J.C., Blandford, A.D., Bogdanovich, S., Hirano, Y., Witta, J., Fuchs, E., Littman, D.R., Ambati, B.K., Rudin, C.M., Chong, M.M.W., Provost, P., Kugel, J.F., Goodrich, J.A., Dunaief, J.L., Baffi, J.Z., Ambati, J. (2011). DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature. 471:325-330. Titov, D.V., Gilman, B., He, Q.-L., Bhat, S., Low, W.-K., Dang, Y., Smeaton, M., Demain, A.J., Miller, P.S., Kugel, J.F., Goodrich, J.A., Liu, J.O. (2011). XPB, a subunit of TFIIH, is a target of the natural product triptolide. Nature Chemical Biology. 7:182-188. PMID: 21278739 Yakovchuk, P., Goodrich J.A., and Kugel, J.F. (2011). B2 RNA represses TFIIH phosphorylation of RNA polymerase II. Transcription. 2:45-49. Nguyen, T.N., Kim, L.J., Walters, R.D., Drullinger, L.F., Lively, T.N., Kugel, J.F., and Goodrich, J.A. (2010). The C-terminal region of human NFATc2 binds cJun to synergistically activate IL-2 transcription. Mol. Immunol. 47: 2314-2322. Yakovchuk, P., Gilman, B, Goodrich, J.A., and Kugel, J.F. (2010). RNA polymerase II and TFIID undergo a rate limiting isomerization after recruitment to promoter DNA. J. Mol. Biol. 397: 57-68. Wagner, S.D., Kugel, J.F., Goodrich, J.A. (2010). TFIIF facilitates dissociation of RNA polymerase II from ncRNAs that lack a repression domain. Mol. Cell. Biol. 30: 91-97. Yakovchuk, P., Goodrich, J.A., and Kugel, J.F. (2009). B2 RNA and Alu RNA repress transcription by disrupting contacts between RNA polymerase II and promoter DNA within assembled complexes. Proc. Natl. Acad. Sci. USA. 106: 5569-5574. Gilman, B., Drullinger, L.F., Kugel, J.F., and Goodrich, J.A. (2009). TATA binding protein and transcription factor IIB induce transcript slipping during early transcription by RNA polymerase II. J Biol Chem. 284: 9093-9098. Mariner, P.D., Walters, R.D., Espinoza, C.A., Drullinger, L.F., Wagner, S.D., Kugel, J.F., and Goodrich, J.A. (2008). Human Alu ncRNA is a modular transacting repressor of mRNA transcription during heat shock. Mol. Cell. 29: 499-509. Hieb, A.R., Halsey, W.A., Betterton, M., Perkins, T., Kugel, J.F., and Goodrich, J.A. (2007). TFIIA changes the conformation of the DNA in TBP/TATA complexes and increases their kinetic stability. J. Mol. Biol. 372: 619-632. Weaver, J.R., Good, K., Walters, R.D., Kugel, J.F., and Goodrich, J.A. (2007). Characterization of the sequence and architectural constraints of the regulatory and core regions of the human interleukin-2 promoter. Mol. Immunol. 44: 2813-2819. Espinoza, C.A., Goodrich, J.A., and Kugel, J.F. (2007). Characterization of the structure, function and mechanism of B2 RNA, an ncRNA repressor of RNA polymerase II transcription. RNA. 13: 583-596. Hofmann, W.A., Vargas, G.M., Ramchandran, R., Ljuba, S., Goodrich, J.A., and de Lanerolle, P. (2006). Nuclear myosin I is necessary for the formation of the first phosphodiester bond by RNA polymerase II. J. Cell. Biochem. 99: 1001-1009. Hieb, A.R., Baran, S., Goodrich, J.A., and Kugel, J.F. (2006). An 8 nt RNA triggers a rate-limiting shift of RNA polymerase II complexes into elongation. EMBO J. 25: 3100-3109. Weaver, J.R., Kugel, J.F., and Goodrich, J.A. (2005). The sequence at specific positions in the early transcribed region sets the rate of transcript synthesis by RNA polymerase II in vitro. J. Biol. Chem. 280: 39860-39869. Hofmann, W.A., Stojiljkovic, L., Fuchsova, B., Vargas, G.M., Mavrommatis, E., Philimonenko, V., Kysela, K., Goodrich, J.A., Lessard, J.L., Hope, T.J., Hozak, P. and de Lanerolle, P. (2004). Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II. Nature Cell Biol. 6: 1094-1101. Espinoza, C.A., Allen, T.A., Hieb, A.R., Kugel, J.F., and Goodrich, J.A. (2004). B2 RNA binds directly to RNA polymerase II to repress transcript synthesis. Nature Struct. Mol. Biol. 11: 822-829. Allen, T.A., Von Kaenel, S., Goodrich, J.A., and Kugel, J.F. (2004). The SINE encoded mouse B2 RNA represses mRNA transcription in response to heat shock. Nature Struct. Mol. Biol. 11: 816-821. Lively, T.N., Nguyen, T.N., Galasinski, S.K., and Goodrich, J.A. (2004). The basic leucine zipper domain of cJun functions in transcriptional activation through interaction with the N terminus of hsTAF1 (human TAFII250). J. Biol. Chem. 279: 26257-26265.