张雪莲 - 复旦大学 - 生命科学学院

个人简介

2003南京农业大学动物医学学院博士学位；2003-2005复旦大学生命科学学院博士后；2005–至今，复旦大学生命科学学院，讲师，副教授；2009- 2010 约翰霍普金斯大学公共卫生学院，访问学者。承担项目主持国家自然科学基金5项，上海市及新疆建设兵团项目3项，参加国家重点研发计划1项 2022.1-2026.12国家自然科学基金（面上） 2020.1-2023.12国家自然科学基金（面上） 2017.1-2020.12国家自然科学基金（面上） 2013.1-2015.12国家自然科学基金（国际合作） 2010.1-2012.12国家自然科学基金（青年）获奖情况 “结核杆菌耐药性分析及结核病防控策略基础研究” 获上海市自然科学三等奖（2015）。获得第三届全国大学生生命科学创新创业大赛，指导教师一等奖（创新类）（2018）

研究领域

主要从事结核病相关基础和应用研究，包括蛋白翻译后修饰调控结核杆菌感染致病的机制、结核杆菌与宿主细胞免疫互作机制，及抗结核新药及耐药机制方面研究

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Luyao Bao#, JuanHu#, Bowen Zhan#, MingzheChi, Zhengyang Li, SenWang,Chan Shan, Zhaozhao Zhao, Yanchao Guo, Xiaoming Ding, Chaoneng Ji,Shengce Tao, Ting Ni, Xuelian Zhang*, Guoping Zhao*，Jixi Li*，Structural insights into RNase J that plays anessential role inMycobacterium tuberculosisRNA metabolism. Nature Communications, 2023,14:2280-2294 Yuchang Di, Siyue Xu, Mingzhe Chi, Youwei Hu, Xiao Zhang, Honghai Wang, Wenhong Zhang*, Xuelian Zhang*, Acetylation of cyclic adenosine monophosphate receptor protein by acetyl phosphate modulates mycobacteria virulence. Microbiology Spectrum, 2023,11(1):e0400222. Weiheng Liao and Xuelian Zhang* Patpat: a public proteomics dataset search framework. Bioinformatics, 2023, 39(2): btad076. Jianing Qian, Youwei Hu, Xiao Zhang, Mingzhe Chi, Siyue Xu, Honghai Wang,Xuelian Zhang*, Mycobacterium tuberculosis PE_PGRS19 induces pyroptosisthrough a non-Classical caspase-11/GSDMD pathwayin macrophages, Microorganisms 2022, 10, 2473-2487. Qinglong Guo, Jing Bi, Honghai Wang,Xuelian Zhang*，Mycobacterium tuberculosis ESX-1-secreted substrate protein EspC promotes mycobacterial survival through endoplasmic reticulum stress-mediated apoptosis,Emerging Microbes &Infections,2021, 10(1)：19-36. Jing Bi (#),Zongchao Gou(#) , Fengzhu Zhou, Yiqing Chen, Jianhua Gan, Jun Liu, Honghai Wang, Xuelian Zhang *,Acetylation of lysine 182 inhibits the ability of Mycobacterium tuberculosis DosR to bind DNA and regulate gene expression during hypoxia, Emerging Microbes & Infections, 2018, (7): 108~120. Jianing Qian, Run Chen, Honghai Wang, Xuelian Zhang*, Role of the PE/PPE Family in Host–Pathogen Interactions and Prospects for Anti-Tuberculosis Vaccine and Diagnostic Tool Design, Frontiers in Cellular and Infection Microbiology 2020,10,article 594288. Qinglong Guo, Jing Bi, Ming Li, Wenxue Ge, Ying Xu, Weixing Fan, Honghai Wang, Xuelian Zhang*, ESX Secretion-Associated Protein C from Mycobacterium tuberculosis Induces Macrophage Activation Through the Toll-Like Receptor-4/Mitogen-Activated Protein Kinase Signaling Pathway, Frontiers in Cellular and Infection Microbiology, 2019,9,158-172.