公晓红 - 复旦大学 - 生命科学学院

个人简介

北京大学医学学士、博士。2005-2007年在法国Institute Pasteur进行博士后研究。2007年起在复旦大学任教。

研究领域

精神分裂症、双相障碍、重性抑郁症、孤独症等重性精神疾病严重危害人类健康。课题组从基因组学、代谢组学、蛋白组学、脑影像等多层次研究精神疾病的基因型-表型关系，挖掘生物标志物以促进疾病的客观诊断；采用小鼠模型解析人类精神疾病重要基因变异的分子病理机制

近期论文

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Hao M#, Qin Y#, Li Y#, Tang Y, Ma Z, Tan J, Jin L, Wang F*, Gong X*.Metabolome subtyping reveals multi-omics characteristics and biological heterogeneity in major psychiatric disorders. Psychiatry Res. 2023 Nov 13;330:115605. Qin Y#, Zhang XY#, Liu Y#, Ma Z, Tao S, Li Y, Peng R, Wang F, Wang J, Feng J, Qiu Z, Jin L, Wang H*, Gong X*.Downregulation of mGluR1-mediated signaling underlying autistic-like core symptoms in Shank1 P1812L-knock-in mice. Transl Psychiatry. 2023 Oct 25;13(1):329. Yue Qin# , Yasong Du# , Liqiang Chen , Yanyan Liu , Wenjing Xu , Ying Liu , Ying Li , Jing Leng , Yalan Wang , Xiao-Yong Zhang , Jianfeng Feng , Feng Zhang , Li Jin , Zilong Qiu , Xiaohong Gong* , Hongyan Wang* . A recurrent SHANK1 mutation implicated in autism spectrum disorder causes autistic-like core behaviors in mice via downregulation of mGluR1-IP3R1-calcium signaling. Molecular Psychiatry. 2022 Jul;27(7):2985-2998. Kang J, Jiao Z, Qin Y, Wang Y, Wang J, Jin L, Feng J, Wang F, Tang Y*, Gong X*.Associations between polygenic risk scores and amplitude of low-frequency fluctuation of inferior frontal gyrus in schizophrenia.J Psychiatr Res. 2022 Jan 3;147:4-12. doi: 10.1016 Zhu Y#, Wang S#, Gong X#, Edmiston EK, Zhong S, Li C, Zhao P, Wei S, Jiang X, Qin Y, Kang J, Wang Y, Sun Q, Gong G, Wang F, Tang Y.Associations between hemispheric asymmetry and schizophrenia-related risk genes in people with schizophrenia and people at a genetic high risk of schizophrenia.Br J Psychiatry. 2021 Jul;219(1):392-400. Chang M#, Womer FY#, Gong X#, Chen X, Tang L, Feng R, Dong S, Duan J, Chen Y, Zhang R, Wang Y, Ren S, Wang Y, Kang J, Yin Z, Wei Y, Wei S, Jiang X, Xu K, Cao B, Zhang Y, Zhang W, Tang Y*, Zhang X*, Wang F*. Identifying and validating subtypes within major psychiatric disorders based on frontal-posterior functional imbalance via deep learning. Mol Psychiatry. 2021 Jul;26(7):2991-3002. Qin Y#, Kang J#, Jiao Z, Wang Y, Wang J, Wang H, Feng J, Jin L, Wang F, Gong X. Polygenic risk for autism spectrum disorder affects left amygdala activity and negative emotion in schizophrenia. Transl Psychiatry. 2020 Sep 21;10(1):322. Zhang L#, Qin Y#, Gong X#, Peng R, Cai C, Zheng Y, Du Y, and Wang H. A promoter variant in ZNF804A decreasing its expression increases the risk of autism spectrum disorder in the Han Chinese population. Transl Psychiatry. 2019 Jan 22;9(1):31.