丁晓明 - 复旦大学 - 生命科学学院

个人简介

男，博士，复旦大学生命科学学院微生物系副教授。1996年本科毕业于武汉大学生命科学学院，获学士学位。2001年毕业于中国科学院上海生命科学研究院植物生理生态研究所，获博士学位。2002-2003年在诺丁汉大学女王医学中心、2003-2005年在阿伯丁大学医学科学研究所进行博士后研究。2005年，进入复旦大学生命科学学院工作，历任讲师，副教授。

研究领域

微生物分子遗传学及代谢调控，合成生物学

近期论文

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Liang J, Wang H, Bian X, Zhang Y, Zhao G, Ding X*. (2020) Heterologous redox partners supporting the efficient catalysis of epothilone B biosynthesis by EpoK in Schlegelella brevitalea. Microb Cell Fact.19(1):180. doi: 10.1186/s12934-020-01439-5. Yu Y, Wang H, Tang B, Liang J, Zhang L, Wang H, Bian X, Li YZ, Zhang Y, Zhao GP*, Ding X*. (2020) Reassembly of the Biosynthetic Gene Cluster Enables High Epothilone Yield in Engineered Schlegelella brevitalea.ACS Synth Biol. 9(8):2009-2022. Tang B, Yu Y, Liang J, Zhang Y, Bian X, Zhi X*, Ding X*. (2019) Reclassification of ＇Polyangium brachysporum＇ DSM 7029 as Schlegelella brevitalea sp. nov. Int J Syst Evol Microbiol. 69(9):2877-2883. Lei X, Fan Q, Huang T, Liu H, Zhao G, Ding X*. (2019) Efficient circular gene knockout system for Burkholderiales strain DSM 7029 and Mycobacterium smegmatis mc2 155. Acta Biochim Biophys Sin. 51(7):697-706. Lei X, Wang L, Zhao G, Ding X*. (2018) Site-specificity of serine integrase demonstrated by the attB sequence preference of phiBT1 integrase. FEBS Lett. 592(8):1389-1399. Yu Y, Tang B, Dai R, Zhang B, Chen L, Yang H, Zhao G*, Ding X*. (2018) Identification of the streptothricin and tunicamycin biosynthetic gene clusters by genome mining in Streptomyces sp. strain fd1-xmd. Appl Microbiol Biotechnol. 102(6):2621-2633. Wang H, Zhao G*, Ding X*.(2017) Morphology engineering of Streptomyces coelicolor M145 by sub-inhibitory concentrations of antibiotics. Sci Rep. 7(1): 13226. Bian X, Tang B, Yu Y, Tu Q, Gross F, Wang H, Li A, Fu J, Shen Y, Li YZ, Stewart AF, Zhao G, Ding X*, Müller R*, Zhang Y*. (2017) Heterologous Production and Yield Improvement of Epothilones in Burkholderiales Strain DSM 7029. ACS Chem Biol. 12(7):1805-1812. Li C, Liu X, Lei C, Yan H, Shao Z, Wang Y, Zhao G, Wang J*, Ding X*. (2017) RifZ (AMED_0655) Is a Pathway-Specific Regulator for Rifamycin Biosynthesis in Amycolatopsis mediterranei. Appl Environ Microbiol. 83(8):e03201-16. Wang X, Tang B, Ye Y, Mao Y, Lei X, Zhao G*, Ding X*. (2017) Bxb1 integrase serves as a highly efficient DNA recombinase in rapid metabolite pathway assembly. Acta Biochim Biophys Sin. 49(1):44-50. Tang B ，Yu Y，Zhi X，Yang L，Cen X，Zhao G* ， Ding X*. (2016) Streptomyces yangpuensis sp. nov., isolated from soil， Int J Syst Evol Microbiol.， 66：1224–1229. Tang B, Yu Y, Zhang Y*, Zhao G*, Ding X*. (2015) Complete genome sequence of the glidobactin producing strain [Polyangium] brachysporum DSM 7029. J Biotechnol. 210:83-84. Bai J, Dan C, Zhang Y, Zhao G*, Ding X*. (2015) NGSmirPlant: comprehensive characterization of the small RNA transcriptomes of plants. Protein & Cell. 6(6): 397-402. Zhang L, Zhu B, Dai R, Zhao G*, Ding X*. (2013) Control of directionality in Streptomyces phage φBT1 integrase-mediated site-specific recombination. PLoS One. 8(11):e80434. Zhang B, Zhang L, Dai R, Yu M, Zhao G*, Ding X*.（2013）An efficient procedure for marker-free mutagenesis of S. coelicolor by site-specific recombination for secondary metabolite overproduction. PLoS One. 8(2) (2013): e55906. Zhang L, Zhao G*, Ding X*. (2011) Tandem assembly of the epothilone biosynthetic gene cluster by in vitro site-specific recombination. Sci Rep. 1:141. Zhang L., Wang L., Wang J., Ou X., Zhao G.*, Ding X.* (2010).DNA cleavage is independent of synapsis during Streptomyces phage phiBT1 integrase-mediated site-specific recombination. J Mol Cell Biol. 2(5):264-275. Zhao W., Zhong Y., Yuan H., Wang J., Zheng H., Wang Y., Cen X., Xu F., Bai J., Han X., Lu G., Zhu Y., Shao Z., Yan H., Li C., Peng N., Zhang Z., Zhang Y., Lin W., Fan Y., Qin Z., Hu Y., Zhu B., Wang S.*, Ding X.*, Zhao G.* (2010).Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism. Cell Res. 20(10):1096-108. Ou X., Zhang B., Zhang L., Zhao G.*, and Ding X.* (2009) Characterization of rrdA, a TetR Family Protein Gene Involved in the Regulation of Secondary Metabolism in Streptomyces coelicolor. Appl Environ Microbiol. 75(7): 2158-2165. Zhang L., Ou X., Zhao G.*, Ding X.* (2008).Highly Efficient In Vitro Site-Specific Recombination System Based on Streptomyces Phage BT1 Integrase. J Bacteriol. 190(19): 6392-6397.