朱乃硕 - 复旦大学 - 生命科学学院

个人简介

复旦大学微生物感染与分子免疫学专业博士导师、教授；遗传工程国家重点实验室和复旦大学生物医学研究院双聘PI，国家863生物医药高技术项目终审评委。上海市免疫学会常务理事，美国杂志Regional Editor,西南大学客藉兼职教授。1983年于南京医科大学获医学士，1991年于上海交通大学获生物化学硕士，1994 年于上海交通大学获分子生物学博士，受教于上海生化与分子生物学会前理事长陈诗书教授，2001年于香港大学医学院微生物系访问学者。获奖情况 (Awards) 曾获中国高校科技进步二等奖两次，中国科协首届青年生命科学大会优秀科技论文奖，获上海第五届青年优秀科技论文奖，卫生厅科技进步二等奖，《免疫学导论》获教育部优秀教材二等奖。申请发明专利1６项, 获专利授权８项，其中３项专利分别获得美国、日本和印度授权

研究领域

分子生物学、免疫学，疾病发生的分子机理及表观遗传学干预和疫苗及免疫基因工程；免疫耐受诱导和免疫增效，肿瘤生长和转移的基因调控，基因检测诊断，器官移植免疫排斥机理和抗排斥研究，病毒免疫耐受形成机理及抗病毒研究

近期论文

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Zheng H, Du G, Zhao R , Tang B, Zhu N * (2009),Enhanced Allogeneic Skin Graft Survival using sCD95L、sCD152、IL-10 and TGF-β in Combination and Comparison with CsA. Clinical and Experimental Dermatology, 34:721-727. Chongwen Zhang，Li Gong，Yuanyuan Chen, Xiaohua Wang, Sibo Zhu, Ding Li, Yun Pang,Yue Yin, Xi Liu, Naishuo Zhu * (2013),A human-derived protein SBP (HBsAg-binding protein) can bind to hepatitis B virus surface antigen (HBsAg) and enhance the immune response to hepatitis B virus (HBV) vaccine,Molecular Immunology. 53: 60-71３. Xiaobo Hu, Rui Liu, Naishuo Zhu *（2013）Enhancement of humoral and cellular immune responses by monophosphoryl lipid A (MPLA) as an adjuvant to the rabies vaccine in BALB/c mice. Immunobiology. 218(2013):1524-1528. L. Xirong, L. Rui, Y. Xiaoli, H. Qiuyan, T. Bikui, Z. Sibo, and Z. Naishuo * (2014) Hepatitis B virus can be inhibited by DNAmMethyltransferase 3a via specific Zinc-Finger-induced methylation of the X promoter. Biochemistry (Moscow). 2014 (2) 13–249. Jiansheng Huang,Xirong Li, Naishuo Zhu * (2012),Genetic characteristics of one highly multi-drugresistantstrain of Klebsiella ozaenae.Journal of Medical Microbiology, 61（9）1303-05,DOI:jmm.0.044115-0. Zhao R, Tang B Zhu NS* NLS-dependent and insufficient nuclear localization of XAGE-1 splice variants. Oncology Reports, （2011）. 25(4):1083-1089. Xu Xiulin; Yang Yujing; Zhu Naishuo*.(2009). Characteristics and molecular mechanism of adhesion proteins on reused hemodialysis membranes. Blood purification 27(4):321-9. Liu Yang; Zhu Qiyun; Zhu Naishuo*.(2008).Recent duplication and positive selection of the GAGE gene family. Genetica 133(1):31-5. Yang Liu, Qiyun Zhu,Naishuo Zhu*.(2007)Rapid HLA-DR fluorotyping based on melting curve analysis. Immunological Investigations 36（4）:507 -521. Zhu NS*, Gao Neng, Wang YingMing, Wang, XiaoHua, Yang Yi. (2004). Expression of the negative co-stimulatory ligand sCD152 in the yeast, Pichia pastoris, and its regulation of antigen specific immune responses. International Immunopharmacology. 4(1):139-148. Zhu NS*, Yang JL, Wang YM, Guan XF. (2003). Study of the difference of high and low metastasis, cell line's gene expression map and metastasis-related genes of adenoid cystic carcinoma. Experiment Molecular Medicine.35 (4): 243-248. Yang JL, Zhu NS*, Wang Y, Guan XF, Zheng ZX.(2004). Protein and mRNA characterization in high and low metastasis adenoid cysticcarcinoma cell lines. Molecular Biology Reports. 31:241-248.