郑煜芳 - 复旦大学 - 生命科学学院

个人简介

1993年进入清华大学生物科学与技术系，1997年获学士学位，1999年获理学硕士学位。1999年8月赴美国康奈尔大学医学院生理、生物物理和分子医学系，于2004年获博士学位。同年获美国耶鲁大学的Endowed Postdoctoral Fellowship，从事博士后研究。2007年起获聘为复旦大学副教授，硕导。2013年8月兼职复旦大学发育生物学研究所PI。2016年3月起任复旦大学附属妇产科医院生殖发育研究院副研究员PI，2017年12月起任研究员。曾获得上海市浦江人才计划，复旦大学卓学人才计划等奖项。曾承担的多项国家自然基金委项目和上海市科委项目；作为课题骨干参与基金委重点项目、国家重点研发计划、973计划、863等多项重大项目。

研究领域

胚胎发育异常导致的重大疾病的分子遗传和发育机制

近期论文

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Li C, Zheng Y, Zheng Y*, Xu Z*. SRPS Associated Protein WDR60 Regulates the Multipolar-to-Bipolar Transition of Migrating Neurons during Cortical Development. Cell Death & Dis. 2021 Jan 12;12(1):75. doi: 10.1038/s41419-020-03363-3. Yin H, Peng R, Chen Z, Wang H, Zhang T, Zheng Y*. WDR34 mutation from anencephaly patients impaired both SHH and PCP signaling pathways. Journal of Human Genetics, 2020 Nov; 65(11):985-993. doi: 10.1038/s10038-020-0793-z. Xu Y, Li X, Zhong Y, Zheng Y*. The evolution and diversity of axon guidance Robo receptor family genes. Journal of Systematics and Evolution, 2021, 59 (1): 169-182, DOI: 10.1111/jse.12587, Xie Y, Ma A, Wang B, Peng R, Jing Y, Wang D, Finnell RH., Qiao B, Wang Y*, Wang H*, Zheng Y*. Rare mutations of ADAM17 from TOFs induce hypertrophy in human embryonic stem cell-derived cardiomyocytes via HB-EGF signaling. Clin Sci (Lond). 2019 Jan 22;133(2):225-238. doi: 10.1042/CS20180842. Wang Y#, Zheng Y#,*, Yang S, Yang Z, Zhang L, He Y, Gong X, Liu D, Finnell R.H., Qiu Z, Du Y*, Wang H*. MicroRNA-197 controls ADAM10 expression to mediate MeCP2’s role in the differentiation of neuronal progenitors. Cell Death & Differ 2019 Oct;26(10):1863-1879. DOI: 10.1038/s41418-018-0257-6 Chen Z#, Lei Y#, Zheng Y#, Aguiar-Pulido V, Ross M.E., Peng R, Jin L, Zhang T*, Finnell R.H.*, Wang H*. Threshold for neural tube defect risk by accumulated singleton loss-of-function variants. Cell Res. 2018 Oct;28(10):1039-1041. doi: 10.1038/s41422-018-0061-3. Wang B, Zhang Y, Dong H, Gong S, Wei B, Luo M, Wang H, Wu X, Liu W, Xu X*, Zheng Y*, Miao Sun*. Loss of Tctn3 causes neuronal apoptosis and neural tube defects in mice. Cell Death & Dis. 2018 May 1; 9(520). doi: 10.1038/s41419-018-0563-4 Gao X, Finnell R, Wang H, Zheng Y*. Network correlation analysis revealed potential new mechanisms for neural tube defects beyond folic acid. Birth Defects Res 2018 Jul 17;110(12):982-993. doi: 10.1002/bdr2.1336. Shi Z, Yang X, Li B, Chen S, Yang L, Chen L, Zhang T, Wang H, Zheng Y*. Novel mutation of LRP6 identified in Chinese Han population links canonical WNT signaling to neural tube defects. Birth Defects Res2018 Jan 15;110(1):63-71. doi: 10.1002/bdr2.1122. Wang B#, Zheng Y#, Shi H, Du X, Zhang Y, Wei B, Luo M, Wang H, Wu X, Hua X, Sun M*, Xu X*. Zfp462 deficiency causes anxiety-like behaviors with excessive self-grooming in mice.Genes Brain Behav. 2017 Feb;16(2):296-307. Qiao X#, Liu Y#, Li P, Chen Z, Li H, Yang X, Finnell RH, Yang Z, Zhang T, Qiao B, Zheng Y*, Wang H*. Genetic analysis of rare coding mutations of CELSR1-3 in congenital heart and neural tube defects in Chinese people. Clin Sci (Lond). 2016 Dec 1; 130(24): 2329-40. Liu B, Ma A, Zhang F, Wang Y, Li Z, Li Q, Xu Z, Zheng Y*.MAZ mediates the cross-talk between CT-1 and NOTCH1 signaling during gliogenesis.Scientific reports 2016 Feb 12;6:21534. doi: 10.1038/srep21534.