Gardiner, John - The University of Manchester

个人简介

BSc (Durham), PhD (Durham). Postdoctoral research: University of California at Los Angeles (UCLA) 1988-90. Visiting Research Fellow: University of California at Los Angeles (UCLA), 1991 and 1992. Lecturer in Medicinal Chemistry : Aston University 1990-93

研究领域

Our research group has interests in synthetic and biological chemistry encompassing methodology, target synthesis, carbohydrate chemistry of various types including oligosaccharide synthesis, biocatalysis and heterocycle chemistry, and also interests in novel dendrimer material synthesis. The group currently comprises a mixture of PDRAs and research students and is based in the Manchester Institute of Biotechnology. Carbohydrates and Oligosaccharides: We have active interests in developing new methods to provide biologically-relevant oligosaccharides, with a focus on tools to probe chemical biology and for biomedical targets. Particularly significant interests are in the synthetic heparin oligosaccharide area where we have recently reported the a large jump in synthetic scalability for long heparins, a new accelerated block synthesis and have also developed the longest synthetic sequcnes yet reported. Biocatalysis: Collaboration with Prof Nigel Scruttons lab discoivering, developing, engineering and applying new enzyme catalysis for high valuae chemical synthesis, using screening, engineering and synthetic biology. Heterocycles: Oligo-heterocyclic synthesis and biological activities (eg DNA ligands). Dendrimers, polyaryls and nanographene: New arhcitectures based on polaryles and their applicatyions nanographenes.

近期论文

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Morjan, R. Y.; Mkadmh, A. M.; Beadham, I.; Elmanama, A. A.; Mattar, M. R.; Raftery, J.; Pritchard, R. G.; Adel M. Awadallah, A. M.; Gardiner, J. M. Antibacterial activities of novel synthetic N-acylhydrazones of nicotinic acid hydrazide and their conversion into N-acetyl-1,3,4-oxadiazoles. Bioorganic & Medicinal Chemistry Letters. 2014; eScholarID:237890 | DOI:10.1016/j.bmcl.2014.10.029 Kadirvel, M.; Fanimarvasti, F.; Forbes, S.; McBain, A.; Gardiner, J. M.; Brown, G. D.; Freeman, S. Inhibition of quorum sensing and biofilm formation in Vibrio harveyi by 4-Fluoro-DPD; a novel potent inhibitor of AI-2 signalling. Chemical Communications. 2014; 50: 5000-5002. eScholarID:237886 | DOI:10.1039/C3CC49678C Aslam, S.; Zaib, S.; Ahmad, M.; Gardiner, J. M.; Ahmad, A.; Hameed, A.; Furtmann, N.; Gütschow, M.; Bajorath, J.; Iqbal, J. Novel structural hybrids of pyrazolobenzothiazines with benzimidazoles as cholinesterase inhibitors. European Journal of Medicinal Chemistry. 2014; 78: 106-117. eScholarID:237887 | DOI:10.1016/j.ejmech.2014.03.035 Morjan, R. Y.; Qesta, B. S.; Al-Shayyah, H. T.; Gardiner, J. M.; Thaher, B. A. A.; Awadallah, A. M. Reaction of Nitrilimines with 2-Aminopicoline, 3-Amino-1,2,4-triazole, 5-Aminotetrazole and 2-Aminopyrimidine. International Journal of Organic Chemistry. 2014; 4: 201-207. eScholarID:237888 Miller, G. J.; Hansen, S. U.; Baráth, M.; Johannessen, C.; Blanch, E. W.; Jayson, G. C.; Gardiner, J. M. Synthesis of a heparin-related GlcN–IdoA sulfation-site variable disaccharide library and analysis by Raman and ROA spectroscopy. Carbohydrate Research. 2014; 400: 44-53. eScholarID:237889 | DOI:10.1016/j.carres.2014.06.026 Jayson, G. C.; Miller, G. J.; Hansen, S. U.; Barath, M.; Gardiner, J. M.; Avizienyte, E. The development of anti-angiogenic heparan sulfate oligosaccharides. Biochemical Society. Transactions. 2014 November; 42: 1596-1600. eScholarID:240415 | DOI:doi:10.1042/BST20140229 Mansell, D.; Toogood, H. S.; Waller, J.; Hughes, J. M. X.; Levy, C.; Gardiner, J. M.; Scrutton, N. S. Biocatalytic asymmetric alkene reduction: crystal structure and characterization of a double bond reductase from Nicotiana tabacum. ACS Catalysis. 2013; 3: 370-379. eScholarID:197146 Miller, G. J.; Hansen, S. U.; Cole. C.; Avizientye, E.; Rushton, G.; Jayson, G. C.; Gardiner, J. M. Efficient chemical synthesis of heparin-like octa-, deca- and dodecasaccharides and inhibition of FGF2- and VEGF165-mediated endothelial cell functions. Chemical Science. 2013; 4(8): 3218-3222. eScholarID:197134 | DOI:10.1039/C3SC51217G Hansen, S. U.; Miller, G. J.; Jayson, G. C.; Gardiner, J. M. First Gram-scale Synthesis of a Heparin-related Dodecasaccharide. Organic Letters. 2013 January; 15(1): 88-91. eScholarID:197133 | DOI:10.1021/ol303112y Takemoto, N.; Suehara, T.; Frisco, H.; Sato, S.-i; Sezaki, T.; Kusamori, K.; Kawazoe, Y.; Park, S. M.; Yamazoe, S.; Mizuhata, Y.; Inoue, R.; Hansen, S. U.; Jayson, G. J.; Miller, G. J.; Gardiner, J. M.; Kanaya, T.; Tokitoh, N.; Ueda, K.; Takakura, Y.; Kioka, N.; Nishikawa, M.; Uesugi, M. Small-Molecule-Induced Clustering of Heparan Sulfate Promotes Cell Adhesion. J. Am. Chem. Soc. 2013 July; 135: 11032-11039. eScholarID:207192 Ahmad, M.; Siddiqui, H. L.; Gardiner, J. M.; Parvez. M; Aslam, S. Synthesis and antioxidant studies of novel N-substituted benzyl/phenyl-2-(3,4-dimethyl-5,5-dioxidopyrazolo[4,3-c][1,2]benzothiazin-2(4H)-yl)acetamides. Med. Chem. Res. 2013; 22: 794-805. eScholarID:207193 Morjan, R. Y.; Mkadmh, A. M.; Abu-Awwad, F. M.; Helliwell, M.; Awadallah, A.M.; Gardiner, J. M. Synthesis, Structural Characterization, and Computational Study of Novel (E)-N’-(1-p-tolylethylidene)furan-2-carbohydrazide. J. Mol. Struct. 2013 September; 1051: 345-353. eScholarID:207191 Hansen, S. U.; Miller, G. J.; Cole. C.; Rushton, G Avizientye, E.; Jayson, G. C.; Gardiner, J. M. Tetrasaccharide iteration synthesis of a heparin-like dodecasaccharide and radiolabelling for in vivo tissue distribution studies. Nature Communications. 2013 July; 4(July): . eScholarID:197135 | DOI:10.1038/ncomms3016