杨青 - 复旦大学 - 生命科学学院

个人简介

杨青，女，博士，复旦大学生命科学学院教授。中国药理学会抗炎免疫药理专业委员会委员，上海市药学会理事，上海市药学会生化药物专业委员会副主任委员。上海市浦江人才。 2000年毕业于北海道大学生物有机化学专业，获博士学位。2001至2003年于北海道大学和岐阜大学进行博士后研究，2004-2006年任东京大学药学部JSPS外国人研究员。2006年回国，先后任复旦大学药学院、生命科学学院副教授，2011年任博士生导师，2012年任教授。先后主持“重大慢性非传染性疾病防控研究专项” 科技重大专项课题，“重大新药创制”科技重大专项课题，国家自然科学基金面上项目，上海市浦江人才计划，上海市生物医药重点课题，教育部博导基金，教育部留学回国人员基金等课题。先后获得中国药学会科学技术奖（2017年，三等；2012年，三等）、上海药学科技奖（2016年，一等；2011年度，三等）、复星医药奖教金（2011年、2012年）、陆宗霖奖教金（2017年）、中国侨界贡献奖（创新人才，2016年）、2016中国科学年度新闻人物候选人、中国技术市场协会金桥奖（2020年，项目二等）。

研究领域

利用生物化学、药物化学、分子药理学等手段，进行疾病发生的分子机制研究及相关药物的研发。重点研究：①IDO（吲哚胺-2,3双加氧酶）催化的色氨酸代谢通路失调与疾病的关系，筛选发现干预IDO及相应的信号传导的抑制剂；②Drug Transporter (药物转运蛋白) 在药物代谢中的功能及其表达、定位的调控机制研究

近期论文

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Yu Yao#, Heng Liang#, Xin Fang, Shengnan Zhang, Zikang Xing, Lei Shi, Chunxiang Kuang, Barbara Seliger, Qing Yang*. What is the prospect of indoleamine 2,3-dioxygenase 1 inhibition in cancer? Extrapolation from the past. Journal of Experimental & Clinical Cancer Research, 2021, 40: 60 Weirui Li, Leilei Guo, Zikang Xing, Xin Fang, Heng Liang, Shengnan Zhang, Lei Shi, Chunxiang Kuang, Leming Shi, Yuanting Zheng*, Yueqing Hu*, Qing Yang*. 43 key gene expressions involved in the effect of indoleamine 2,3-dioxygenase 1 (IDO1) expression on cancer prognosis may be a potential IDO1 inhibitor biomarker. Clinical and Translational Medicine, 2021;11:e330 Shengnan Zhang, Leilei Guo, Dan Yang, Zikang Xing, Weirui Li, Chunxiang Kuang, Qing Yang*. Evaluation and Comparison of the Commonly Used Bioassays of Human Indoleamine 2,3-dioxygenase 1(IDO1) and Tryptophan 2,3- dioxygenase (TDO) Bioorganic Chemistry, Volume 104, 2020, 104348 Zhenzhen Duan, Shengnan Zhang, Heng Liang, Zikang Xing, Leilei Guo, Lei Shi, Lisha Du, Chunxiang Kuang, Osamu Takikawa, Qing Yang*. Amyloid β neurotoxicity is IDO1-Kyn-AhR dependent and blocked by IDO1 inhibitor. Signal Transduction and Targeted Therapy, 2020, 5: 96. Lisha Du, Zikang Xing, Bangbao Tao, Tianqi Li, Dan Yang, Weirui Li, Yuanting Zheng, Chunxiang Kuang, Qing Yang*. Both IDO1 and TDO contribute to the malignancy of gliomas via Kyn-AhR-AQP4 signal pathway. Signal Transduction and Targeted Therapy. 2020, 5:10 Dan Yang, Shengnan Zhang, Xin Fang, Leilei Guo, Nan Hu, Zhanling Guo, Xishuai Li, Shuangshuang Yang, Jin Chao He, Chunxiang Kuang* andQing Yang* N-benzyl/aryl substituted Tryptanthrin as Dual Inhibitors of Indoleamine 2, 3-Dioxygenase and Tryptophan 2, 3-dioxygenase. J. Med. Chem.2019,62 (20), 9161-9174. Dan Yang, Tianqi Li, Yinlong Li, Shengnan Zhang, Weirui Li, Heng Liang, Zikang Xing, Lisha Du, Jinchao He, Chunxiang Kuang, Qing Yang*, H2S suppresses indoleamine 2, 3-dioxygenase 1 and exhibits immunotherapeutic efficacy in murine hepatocellular carcinoma. Journal of Experimental & Clinical Cancer Research, 2019, 38:88. Heng Liang?, Mantian Chen?, Fangfei Qi?, Lei Shi, Zhenzhen Duan, Ruoyu Yang, Jinchao He, Bin Lou, Yigang Li*, Qing Yang*.The proatherosclerotic function of indoleamine 2, 3-dioxygenase 1 in the developmental stage of atherosclerosis. Signal Transduction and Targeted Therapy, 2019, 4:23. Shengnan Zhang, Fangfei Qi, Xin Fang, Dan Yang, Hairong Hu, Qiang Huang, Chunxiang Kuang, Qing Yang*, Tryptophan 2,3-dioxygenase Inhibitory Activities of Tryptanthrin Derivatives. Eur J Med Chem. 2018,160, 133-145. Yang Li, Nan Hu, Dan Yang, Gregory Oxenkrug, Qing Yang*, Regulating the balance between the kynurenine and serotonin pathways of tryptophan metabolism, FEBS J., 2017, 284, 948-966. Juanjuan Li, Yang Li, Dan Yang, Nan Hu, Zhanling Guo, Chunxiang Kuang and Qing Yang*, Establishment of a human indoleamine 2, 3-dioxygenase2 (hIDO2) bioassay system and discovery of tryptanthrin derivatives as potent hIDO2 inhibitors. Eur J Med Chem. 2016, 123:171-179. Guiying Jin?, Yang Li?, Yuwen Zhu, Lisha Du, Junkai Yan and Qing Yang*, SMS regulates the expression and function of P-gp and MRP2 in Caco-2 cells. Cell Biology and Toxicology, 2016, 32(6):483-497. Yu D#, Tao BB#, Yang YY, Du LS, Yang SS, He XJ, Zhu YW, Yan JK, Yang Q*. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis,2015, 43(1):291-302. Junkai Yan, Guiying Jin, Lisha Du, and Qing Yang*. Modulation of intestinal folate absorption by erythropoietin in vitro. Mol. Pharmaceutics, 2014, 11(1), 358-366. Yang, Shuangshuang?, Li, Xishuai?, Hu, Fangfang, Li, Yinlong, Yang, Yunyun, Yan, Junkai, Kuang, Chunxiang, Yang, Qing*, Discovery of Tryptanthrin Derivatives as Potent Inhibitors of Indoleamine 2, 3-Dioxygenase with Therapeutic Activity in LLC tumor-bearing Mice.J. Med. Chem.2013, 56 (21),8321–8331. Xiao-Jie He, Wei-Rong Wang, Yun Zhang, Qing Yang*. The Effect of Radixin Knockdown on the Expression and Efflux Function of MRP2 in SGC-7901 Cells. Eur. J. Pharm. Sci, 2012, 46,426-434. Qiang Huang?, Maofa Zheng?, Shuangshuang Yang, Chunxiang Kuang, Cunjing Yu, Qing Yang*, Structure-activity relationship and enzyme kinetic studies on 4-aryl-1H-1, 2, 3-triazoles as indoleamine 2, 3-dioxygenase (IDO) inhibitors. Eur. J. Med. Chem, 2011, 46(11), 5680-5687. Yu Zhang, Jibin Dong, Xingang Zhu, Weirong Wang, Qing Yang*. The Effect of Sphingomyelin Synthase 2 (SMS2) Deficiency on the Expression of Drug Transporters in Mouse Brain. Biochem.Pharmacol, 2011, 82, 287–294. CunJing Yu, MaoFa Zheng, ChunXiang Kuang, WeiDa Huang, Qing Yang*. Oren-gedoku-to and its constituents with therapeutic potential of Alzheimer′s disease inhibit indoleamine 2, 3-dioxygenase activity in vitro. J Alzheimers Dis, 2010, 22 (1), 257-266. 张胜男,刘鑫, 杨青*. 吲哚胺2,3-双加氧酶1及其抑制剂的研究, 复旦学报(医学版), 2017, 44(1), 1-7. 孔令雷, 匡春香, 杨青*, IDO抑制剂的研究进展. 中国药物化学杂志. 2009, 19,147-154.