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个人简介

复旦大学智能复杂体系基础理论与关键技术实验室、类脑智能科学与技术研究院, 教授,南京大学凝聚态物理学博士(2001),美国卡耐基梅隆大学计算神经科学博士后(2004),耶鲁大学医学院研究科学家(2010),上海高校特聘教授‘东方学者’(2013)和跟踪计划(2017)。上海生物物理学会理事,中国计算神经科学学会委员、自动化控制和生物工程协会委员,Frontiers in Computational Neuroscience副主编, Cognitive Neurodynamics编委。研究方向包括大脑神经信号动力学特性和生物物理机制、神经信息处理和神经计算、神经元和神经网络计算模型,仿生智能等。近年来构建了哺乳动物和人脑能量连接图谱三维数学模型,揭示脑皮层普适性信号传导和基础代谢依赖的大脑耗能规律和机制。从离子通道层次到神经元、神经网络和神经环路等多个尺度,研究了高等动物大脑如何实现低功耗神经网络线路连接、和高效节能处理信息和神经计算机制。在Nature, PNAS, Neuron, Physical Review Letters, J Neurosci, PLoS Comp Biol, J Cereb Blood Flow & Metabolism等学术期刊发表SCI论文60余篇,主持/承担国家基金项目10余项。 教育经历 兰州大学 物理学 学士 (1995) 南京大学凝聚态物理博士 (2001) 卡耐基梅隆大学 计算神经科学 博士后 (2004) 耶鲁大学神经生物学研究科学家(2011) 工作经历 智能复杂体系基础理论与关键技术实验室 (2020- ) 教授 复旦大学表型研究院 (2018- ) 教授 复旦大学生命科学学院 (2014-2020) 教授 复旦大学医学神经生物学国家重点实验室 (2015- ) 研究员 复旦大学计算系统生物学中心 (2011-2014) 研究员 耶鲁大学核磁共振成像中心 (2010-2012) 副研究员

研究领域

类脑智能和计算神经科学 神经计算模型 神经编码理论 网络拓扑分析 感知融合机制 脑联接网络图谱 自组织学习算法 多感知融合模型 人脑低功耗机制

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Mingyi Huang and Yuguo Yu* (2023). Wiring Cost Minimization: A Dominant Factor in the Evolution of Brain Networks across Five Species, 2023 CogSci (CCF-B). Hao Shen and Yuguo Yu* (2023). Robust Evaluation and Comparison of EEG Source Localization Algorithms for Accurate Reconstruction of Deep Cortical Activity. Mathematics, 11(11):2450. https://doi.org/10.3390/math11112450 Zhongyu Chen, Yuguo Yu*, and Xiangyang Xue (2023). A Connectome-Based Digital Twin Caenorhabditis elegans Capable of Intelligent Sensorimotor Behavior. Mathematics, 11(11):2442. https://doi.org/10.3390/math11112442 Ruizhe Zheng*, Jun Li*, Yi Wang, Tian Luo, and Yuguo Yu (2023). ScatterFormer: Locally-Invariant Scattering Transformer for Patient-Independent Multispectral Detection of Epileptiform Discharges. 37th AAAI Conference on Artificial Intelligence, Washington, DC. https://arxiv.org/abs/2304.14919 Peng Tao#, Qifan Wang#, Jifan Shi#, Xiaohu Hao, Xiaoping Liu, Bin Min, Yiheng Zhang, Chenyang Li, He Cui*, Luonan Chen*. Detecting dynamical causality by intersection cardinal concavity. Accepted by Fundamental Research. (2023). https://doi.org/10.1016/j.fmre.2023.01.007 Qunxi Zhu*, Xin Li, Wei Lin* [2023], Leveraging neural differential equations and adaptive delayed feedback to detect unstable periodic orbits based on irregularly-sampled time series, CHAOS, Fast Track, Editor's Pick, 33(3): 031101. https://aip.scitation.org/doi/10.1063/5.0143839 Jingdong Zhang, Qunxi Zhu*, Wei Yang*, Wei Lin* [2023], SYNC: Safety-aware Neural Control for Stabilizing Stochastic Delay-Differential Equations, The Eleventh International Conference on Learning Representations (ICLR 2023). https://openreview.net/forum?id=_8mS2NE-HXN Zhang J, Huang M, Gu Y, *Chen A and *Yu Y, (2022),Visual-based spatial coordinate dominates probabilistic multisensory inference in Macaque MST-d disparity encoding. Brain Sciences, 12,1387. https://doi.org/10.3390/brainsci12101387 *Yu Y, Herman P, Rothman DL, Agarwal D, & *Hyder F. (2022), A 3D atlas of functional human brain energetic connectome based on neuropil distribution, Cerebral Cortex, 1-17, https://doi.org/10.1093/cercor/bhac322 Zhang J, Gu Y, *Chen A and *Yu Y, (2022) Unveiling dynamical systems strategies for multisensory processing: from neuronal fixed-criterion integration to population Bayesian inference, Research, 2022,1-12. https://doi.org/10.34133/2022/9787040 Pei X, Xu G, Zhou Y, Tao L, Cui X, Wang Z, Xu B, Wang A, Zhao X, Dong H, An Y, Cao Y, Li R, *Hu H and *Yu Y, 2022, A simultaneous EEG and eye-tracking dataset in elite athletes during alertness and concentration tasks, Scientific Data, 9(1): 1-15. https://doi.org/10.1038/s41597-022-01575-0 Du, M., Li, J., Ying, W., & *Yu, Y. (2022). A dynamics model of neuron-astrocyte network accounting for febrile seizures. Cognitive Neurodynamics, 16(2), 411-423. https://doi.org/10.1007/s11571-021-09706-w Qi X, Wang Y, Lu Y, Zhao Q, Chen Y, Zhou C, & *Yu Y. (2022). Enhanced brain network flexibility by physical exercise in female methamphetamine users. Cognitive Neurodynamics, 1-17. https://doi.org/10.1007/s11571-022-09848-5 Jifan Shi, Kazuyuki Aihara, Tiejun Li, and Luonan Chen. Energy landscape decomposition for cell differentiation with proliferation effect. National Science Review, 9(8): nwac116, 2022.】 https://doi.org/10.1093/nsr/nwac116 Yang Li, Jifan Shi, and Kazuyuki Aihara. Mean-field analysis of Stuart-Landau oscillator networks with symmetric coupling and dynamical noise. Chaos, 32: 063114, 2022. https://doi.org/10.1063/5.0081295 Jingdong Zhang, Qunxi Zhu*, Wei Lin* [2022], Neural Stochastic Control, The Thirty-sixth Conference on Neural Information Processing Systems (NeurIPS 2022). https://openreview.net/forum?id=5wI7gNopMHW Qunxi Zhu*, Yifei Shen, Dongsheng Li, Wei, Lin* [2022], Neural Piecewise-Constant Delay Differential Equations, Proceedings of the Thirty-Sixth AAAI Conference on Artificial Intelligence (AAAI 2022). https://ojs.aaai.org/index.php/AAAI/article/download/20911/20670 Zheng G, Li YZ, Qi XY, Zhang W, *Yu Y, (2021) Mental Calculation Drives Reliable and Weak Distant Connectivity While Music Listening Induces Dense Local Connectivity, Phenomics, 1.6: 285-298. https://doi.org/10.1007/s43657-021-00027-w Lei Y, Li Y, Yu L, Xu L, Zhang X, Zheng G, Chen L, Zhang W, Qi X, *Gu Y, *Yu Y and Mao Y. (2021),Faded Critical Dynamics in Adult Moyamoya Disease Revealed by EEG and fMRI. Oxidative Medicine and, Cellular Longevity, 1-17. https://doi.org/10.1155/2021/6640108 Pei X, Qi X, Jiang Y, Shen X, Wang AL, Cao Y, Zhou C & Yu Y*. (2021) Sparsely Wiring Connectivity in the Upper Beta Band Characterizes the Brains of Top Swimming Athletes. Frontiers in Psychology, 12:661632. https://doi.org/10.3389/fpsyg.2021.661632 Lu Y, Qi X, Zhao Q, Chen Y, Liu Y, Li X, Yu Y* & Zhou C*. (2021) Effects of exercise programs on neuroelectric dynamics in drug addiction. Cognitive Neurodynamics, 15(1), 27-42. https://doi.org/10.1007/s11571-020-09647-w Zheng G, Lei Y, Li Y, Zhang W, Su J, Qi X, *Gu Y, *Yu Y & Mao, Y. (2021) Changes in Brain Functional Network Connectivity in Adult Moyamoya Diseases. Cognitive Neurodynamics, 15.5: 861-872. https://doi.org/10.1007/s11571-021-09666-1 Zhou Y and *Yu Y, (2021) Human Visual Search Follows Suboptimal Bayesian Strategy Revealed by a Spatiotemporal Computational Model and Experiment. Communications Biology, 4(1),1-16. https://doi.org/10.1038/s42003-020-01485-0 Wang X, Liu H, Morstein J, Novak AJE, Trauner DH, *Xiong Q, *Yu Y, and *Ge S, (2020) Metabolic tuning of inhibition regulates hippocampal neurogenesis in the adult brain, Proc Natl Acad Sci (PNAS), 117(41):25818-25829. https://doi.org/10.1073/pnas.2006138117 Zhou Y and *Yu Y, (2021) Human Visual Search Follows Suboptimal Bayesian Strategy Revealed by a Spatiotemporal Computational Model and Experiment.Communications Biology, 4,34. Lu Y, Qi X, Zhao Q, et al, *Yu Y and *Zhou C (2020) Effects of exercise programs on neuroelectric dynamics in drug addiction. Cognitive Neurodynamics, 1-16. Wang X, Liu H, Morstein J, Novak AJE, Trauner DH, *Xiong Q, *Yu Y, and *Ge S, (2020) Metabolic tuning of inhibition regulates hippocampal neurogenesis in the adult brain, Proc Natl Acad Sci (PNAS), 117(41):25818-25829. Lei Y, Song B, Chen L, et al. Yu Y and *Gu Y.(2020)Reconfigured functional network dynamics in adult moyamoya disease: a resting-state fMRI study. Brain Imaging and Behavior. 14:715–727 Chen Z, He Y, *Yu Y,(2020) Attention restoration during environmental exposure via alpha-theta oscillations and synchronization. Journal of Environmental Psychology, 68, 101406. Yang L, Jin Y, Wang X, Yu B, Chen R, Zhang C, Yu Y & Wei, D. (2020) Antifouling Field‐Effect Transistor Sensing Interface Based on Covalent Organic Frameworks. Advanced Electronic Materials, 6(5), 1901169. Fu X and *Yu Y. (2019) Reliable and efficient processing of sensory information at body temperature by rodent cortical neurons. Nonlinear Dynamics, 98(1):215-31. YZ Li, GX Zheng, XY Qi, *Yu Y. (2019) Critical Dynamics Characteristics of Human Brain EEG Activity During Music-listening State and Resting State, Journal of Fudan University 05-0586-10. Yu B, Jin Y, Shen Y, Yang Y, Wang G, Zhu H, *Yu Y & *Wang J. (2019) Loss of homeoprotein Msx1 and Msx2 leading to athletic and kinematic impairment related to the increasing neural excitability of neurons in aberrant neocortex in mice. Biochemical and Biophysical Research Communications. 516 (1), 229-235. *Yu Y, Herman P, Rothman DL, Agarwal D, & Hyder F. (2019). Human brain gray matter energy map computed on the basis of cellular staining from BigBrain. Journal of Cerebral Blood Flow & Metabolism, 39, 205. Qu G, Fan B, Fu X, & *Yu Y. (2019) The impact of frequency scale on the response sensitivity and reliability of cortical neurons to 1/fβ input signals. Frontiers in cellular neuroscience, 13, 311. Zhang W, Fan, B, Agarwal D, Li T, & *Yu Y. (2019) Axonal sodium and potassium conductance density determines spiking dynamical properties of regular-and fast-spiking neurons. Nonlinear Dynamics, 95(2), 1035-1052. Yu L, Shen Z, Wang C, & *Yu Y (2018) Efficient coding and energy efficiency are promoted by balanced excitatory and inhibitory synaptic currents in neuronal network.Frontiers in cellular neuroscience, 12, 123. Du MM, *Yu Y and *Wu Y, (2018) Astrocytic Kir4.1 channels and gap junctions account for spontaneous epileptic seizure, PLoS Comp. Biol. 14(3): e1005877 Zheng G, Qi X, Li Y, Zhang W, *Yu Y. (2018)A comparative study of standardized infinity reference and average reference for EEG of three typical brain states. Frontiers in Neuroscience. 2018;12:158. Liu Y, Yue Y, Yu Y, Liu L, and Yu LC, (2018) Effects of channel blocking on information transmission and energy efficiency in squid giant axons. Journal of Computational Neuroscience. 44(2):1-13. Zhou SL and *Yu Y, (2018) Synaptic E-I balance underlies efficient neural coding,Frontiers in Neuroscience. 12:46. Wang YY, Wang PX and *Yu Y, (2018) Decoding English alphabet letters using EEG phase information, Frontiers in Neuroscience. 12:62 *Yu Y, Herman P, Rothman DL, Agarwal D and Hyder F, (2018) Evaluating the gray and white matter energy budgets of human brain function, Journal of Cerebral Blood Flow & Metabolism, 38(8):1339-1353. Yu LC and *Yu Y, (2017) Energy-Efficient Neural Information Processing in Individual Neurons and Neuronal Networks, Journal of Neuroscience Research. 95(11):2253-2266. Li J, Xie Y, Yu Y, Wu Y, (2017) A neglected GABAergic astrocyte: Calcium dynamics and involvement in seizure activity. Sci. China Technol. Sci. 60: 1003. Fan, BQ, He Y, *Yu Y (2016) 1/f Characteristic in Natural Signals and Sensory Neural Response Properties. SCIENTIA SINICA Vitae, 46(4), 374-384. Chen Z, He Y, *Yu Y (2016) Enhanced functional connectivity properties of human brains during in- situ nature experience, PeerJ, 4:e2210 Ye W, Liu S, Liu X and Yu Y (2016) A neural model of the frontal eye fields with reward-based learning. Neural Networks 81:39–51. Ju H, Hines ML, *Yu Y (2016) Cable energy function of cortical axons,Scientific Report. 6:29686. Yu LC, Zhang C, Liu YW and *Yu Y (2016) Energy-efficient population coding constrains network size of a neuronal array system, Scientific Report. 6:193691-8 Zhou S, Migliore M and *Yu Y (2016) Odor experience facilitates sparse representations of new odors in a large-scale olfactory bulb model.Front in neuroanat. 10:10. Pan XL. et al, ... *Yu Y and *Zhong CJ. (*Co-PI) (2016)Measurement of Blood Thiamine Metabolites for Alzheimer’s disease Diagnosis, EBioMedicine, 26(3):155-162. Zhang W, Yang HL, Song JJ, Chen M, Dong Y, Lai B, Yu Y, Ma L and Zheng P, (2015) AMGO depresses inhibitory synaptic transmission via different downstream pathways of μ opioid receptors in ventral tegmental area and periaqueductal gray. Neuroscience 301, 144-154 Li JJ, Liu SB, Liu WM, Yu Y, Wu Y. (2015) Suppression of firing activities in neuron and neurons of network induced by electromagnetic radiation, Nonlinear Dynamics, 1-10 *Yu Y, Migliore M, Hines ML, and Shepherd GM (2014) Sparse coding and lateral inhibition arising from balanced and unbalanced dendrodendritic excitation and inhibition, Journal of Neuroscience 34: 13701-13713. *Yu Y, Karbowski J, Sachdev RN, Feng J. (2014) Effect of temperature and glia in brain size enlargement and origin of allometric body-brain size scaling in vertebrates. BMC Evol Biol, 2014, 14:71801-71814. *Yu Y. (2014) Constant Warm Body Temperature Ensures High Response Reliability of Neurons in Endothermic Brains. Austin J Comput Biol Bioinform, 1(1): 5. *Yu Y, McTavish TS, Valenti C, Hines ML, Shepherd GM and Migliore M. (2013) Sparse distributed representation of odors in a large-scale olfactory bulb circuit. PLoS Comp. Biol., 2013 9(3): e1003014. Yu Y, Hill A. and McCormick DA. (2012) Warm body temperature facilitates energy efficient cortical action potentials. PLoS Comp. Biol., 8(4) e1002456. Foust AJ, Yu Y, Popovic M, Zecevic D and McCormick DA (2011)Somatic Membrane Potential and Kv1 Channels Control Spike Repolarization in Cortical Axon Collaterals and Presynaptic Boutons.Journal of Neuroscience, 31(43):15490-15498. Yu Y, Maureira C and McCormick DA (2010) P/Q and N channels control baseline and spike-triggered calcium levels in neocortical axons and synaptic boutons, Journal of Neuroscience, 30: 118580-11869 Haider B, Krause MR, Duque A, Yu Y, Touryan J, Mazer JA, McCormick DA (2010) Synaptic and network mechanisms of sparse and reliable visual cortical activity during non-classical receptive field stimulation. Neuron, 65: 107-121 Ros H, Sashdev R, Yu Y, Sestan N and McCormick D.A.Neocortical Networks Entrain Neuronal Circuits in Cerebellar Cortex.Journal of Neuroscience, 29: 10309-20, (2009) Yu Y, Shu Y, Duque A, Haider B and McCormick DA (2008) Cortical Action Potential Back-propagation Explains Spike Threshold Variability and Rapid-Onset Kinetics. Journal of Neuroscience, 28: 7260-7272. PMCID: 2664555 McCormick DA, Shu Y and Yu Y (2007) Hodgkin and Huxley model—still standing? Nature. 445: E1-E2. Shu Y, Yu Y, Yang J and McCormick DA (2007) Selective control of cortical axonal action potentials by a slowly inactivating K+ current. Proc Natl Acad Sci USA (PNAS) 27: 11453-11458. Shu Y, Duque A, Yu Y, Haider B and McCormick DA (2007) Properties of action potential initiation in neocortical pyramidal cells: evidence from whole cell axon recordings. Journal of Neurophysiology 97: 746-760. Haider B., Duque A., Hasenstaub A.R., Yu Y.G., McCormick D.A. (2007) Enhancement of visual responsiveness by spontaneous local network activity in vivo. Journal of Neurophysiology 97: 4186-4202 Shu Y, Hasenstaub A, Duque A, Yu Y and McCormick DA (2006) Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential. Nature 441(7094):761-5. *Yu Y, Richard RD and Lee TS (2005) Preference of sensory neural coding for 1/f signals. Phys Rev Lett, 94, 1081031-4 *Yu Y, Potetz B and Lee TS (2005) The role of spiking nonlinearity in contrast gain control and information transmission. Vis Res 45(5) 583-92. Yu Y, Richard RD and Lee TS. (2005)Adaptive contrast gain control and information maximization. Neurocomputing, 65-66 111-116 *Yu Y, Liu F, Wang W. and Lee TS.(2004)Optimal synchrony state for maximal information transmission. NeuroReport, 15(10):1605-10 Wang S, Liu F, Wang W and Yu Y (2004)Impact of Spatially correlated noise on neuronal firing. Phys Rev E, 69, 0119091-0119097. Yu Y, Liu F, Wang J. and Wang W. (2003) Synchronized Rhythmic Oscillation in a Noisy Neural Network. Journal of the Physical Society of Japan. 72, 3291-3296 *Yu Y and Lee TS (2003) Dynamical mechanisms underlying contrast gain control in single neurons. Phys Rev E 68, 0119011-0119017. Yu Y and Lee TS. (2003)Adaptation of the transfer function of the Hodgkin-Huxley (HH) neuronal model. Neurocomputing 52-54, 441-446 Romero R, Yu Y, Afshar P and Lee TS. (2003) Adaptation of the temporal receptive fields of Macaque V1 neurons. Neurocomputing 52-54, 135-140. Yu Y, Wang W, Wang J, and Liu, F. (2001)Resonance-enhanced signal detection and transduction in Hodgkin-Huxley neuronal systems. Physical Review E, 63, 0219071-02190712 Yu Y, Liu F and Wang W. (2001)Spike timing precision for a neuronal array with periodic signal.Physics Letters A, 282, 23-30 Liu F, Yu Y and Wang W. (2001)Signal-to-noise gain in nervous systems. Physical Review E, 63, 0519121-0519124 Yu Y Liu F and Wang W. (2001)Frequency sensitivity in Hodgkin-Huxley systems. Biological Cybernetics, 84, 227-233 Yu Y and Wang W. (2001)Generation of Spontaneous Synchronized Rhythm and its Role in Information Processing. Chinese Physics Letters, 18, 295-298 Liu F, Yu Y, and Wang W,(2000)Information Representation and Its Application to Stochastic Resonance. Journal of the Physical Society of Japan, 69, 4107-4111

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