王纲 - 复旦大学 - 生命科学学院

个人简介

王纲，复旦大学生命科学学院特聘教授，长期研究发育与疾病的转录及表观遗传调控；作为通讯作者在Mol Cell，Dev Cell，Genes Dev，EMBO J，PNAS，Nature Comm，PloS Biol等杂志发表论文。多项工作作为Mol Cell，EMBO J等重要学术期刊的封面文章发表，获同期专评，以及Faculty1000, Nature Asia-AIMBN, BioArt,“知识分子”的亮点评论。现任中国细胞生物学学会资深理事、Asian Transcription Conference 国际组委、JBC、TRANSCRIPTION学术期刊编委，获“百人计划”和“上海浦江人才计划”及“国务院特殊津贴”支持，作为首席科学家先后主持国家重大科学研究计划、国家重点研发计划项目及国家自然科学基金重点项目。

研究领域

本实验室长期专注于转录中介体的分子调控机理及其在发育（成体干细胞分化等）和疾病（代谢疾病、神经相关疾病、癌症等）中的功能研究。发现转录中介体（Mediator）在mRNA剪切加工、转录延伸、以及DNA损伤修复过程中的非经典功能；首次提出平滑肌与脂肪细胞的“双向调控”及其共同起源；发现Mediator不同亚基在胚胎干细胞干性维持及多谱系细胞分化中的不同功能；发现转录中介体亚基MED23参与调控间充质干细胞向成骨细胞分化过程并影响成骨的发育；揭示Mediator作为表观遗传调控因子,调控癌症与肌肉细胞分化之间的拮抗作用等

近期论文

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Xiaobo Fu#, Siming Liu#, Dan Cao, Chonghui Li, Hongbin Ji, Gang Wang*. Med23 deficiency reprograms the tumor microenvironment to promote lung tumorigenesis. British Journal of Cancer 2023; In press Yenan Yang#, Chonghui Li#, Ziying Chen, Yiyang Zhang, Qing Tian, Meiling Sun, Shuai Zhang, Miao Yu*, Gang Wang*. An intellectual disability-related MED23 mutation dysregulates gene expression by altering chromatin conformation and enhancer activities. Nucleic Acids Research 2023, 51(5), 2137-2150. Yenan Yang#, Qi Xiao#, Jingwen Yin, Chonghui Li, Decai Yu, Yulong He, Zhongzhou Yang*, Gang Wang*. Med23 supports angiogenesis and maintains vascular integrity through negative regulation of angiopoietin2 expression. Communications Biology 2022, 5: 374. Yangyang Li#, Ying Lu#, Shuhai Lin, Ning Li, Yichao Han, Qianru Huang, Yi Zhao, Feng Xie, Yixian Guo, Biaolong Deng, Andy Tsuna, Juan Du, Dan Li, Joanne Sun, Guochao Shi, Fang Zheng, Xiao Su, Shengzhong Duan, Song Guo Zheng, Gang Wang*, Xuemei Tong* & Bin Li*.Insulin signaling establishes a developmental trajectory of adipose Treg cells. Nature Immunology 2021, 22(9):1175-1185. Xiaoli Sun#, Jing-wen Yin#, Yan Liang, Chonghui Li, Pingjin Gao, Ying Yu, Gang Wang*. Mediator Med23 deficiency in smooth muscle cells prevents neointima formation after arterial injury. Cell Discovery 2021, 7(1):59. Yenan Yang, Xiaoli Zhu, Xiang Jia, Wanwan Hou, Guoqiang Zhou, Zhangjing Ma, Bin Yu, Yan Pi, Xumin Zhang, Jingqiang Wang, and Gang Wang*. Phosphorylation of Msx1 promotes cell proliferation through the Fgf9/18-MAPK signaling pathway during embryonic limb development. Nucleic Acids Research 2020, 48(20): 11452-11467. Zhichao Wang#, Dan Cao#, Chonghui Li, Lihua Min, Gang Wang*. Mediator MED23 regulates inflammatory responses and liver fibrosis. PLoS Biology 2019;17(12): e3000563. Min Xia, Kun Chen,Xiao Yao, Yichi Xu,Jiaying Yao, Jun Yan, ZhenShao, andGang Wang*. Mediator subunit MED23 links pigmentation and DNA repair through the transcription factor MITF. Cell Reports 2017; 20(8):1794-1804. Zhen Liu, Xiao Yao, Guang Yan, Yichi Xu, Jun Yan, Weiguo Zou*, Gang Wang*. Mediator MED23 cooperates with RUNX2 to drive osteoblast differentiation and bone development. Nat Commun 2016; 7:11149. Xiao Yao, Zhanyun Tang, Jingwen Yin, Yan Liang, Xing Fu, Robert G. Roeder,Gang Wang*. The Mediator subunit MED23 couples H2B mono-ubiquitination to transcriptional control and cell fate determination. EMBO J 2015; 34(23):2885-902. (Cover story with commentary) Wanqu Zhu, Xiao Yao, Yan Liang, Dan Liang, Lu Song, Naihe Jing, Jinsong Li, Gang Wang*. Mediator Med23-deficiency Enhances Neural Differentiation of Embryonic Stem Cells through Modulating BMP Signaling. Development 2015; 142(3):465-76. Yang Sun, Xiaoyan Zhu, Xufeng Chen, Haifeng Liu, Yu Xu, Yajing Chu, Gang Wang*, Xiaolong Liu*. The mediator subunit Med23 contributes to controlling T-cell activation and prevents autoimmunity. Nat Communs 2014; 5:5225. Jingwen Yin, and Gang Wang*. The Mediator complex: a master coordinator of transcription and cell lineage development. Development 2014; 141:977-987. (Invited review) Yajing Chu, Leonardo Gomez Rosso, Ping Huang, Zhichao Wang, Yichi Xu, Xiao Yao, Menghan Bao, Jun Yan, Haiyun Song, Gang Wang*. Liver Med23 ablation improves glucose and lipid metabolism through modulating FOXO1 activity. Cell Res 2014; 24:1250-1265. Yong Yu, Dan Liang, Qing Tian, Xiaona Chen, Bo Jiang, Binkuan Chou, Ping Hu, Linzhao Cheng, Ping Gao, Jinsong Li, Gang Wang*. Stimulation of somatic cell reprogramming by ERas-Akt-FoxO1 signaling axis. Stem Cells 2014; 32:349-363. Meng Zhao, Xu Yang, Yu Fu, Haifang Wang, Yuanheng Ning, Jun Yan, Ye-Guang Chen, Gang Wang*. Mediator MED15 modulates transforming growth factor beta (TGFβ)/Smad signaling and breast cancer cell metastasis. J Mol Cell Biol2013 Feb;5(1):57-60. Jingwen Yin, Yan Liang, JiYeon Park, Dongrui Chen, Xiao Yao, Qi Xiao, Zhen Liu, Bo Jiang, Yu Fu, Menghan Bao, Yan Huang, Yuting Liu, Jun Yan, Minsheng Zhu, Zhongzhou Yang, Pingjin Gao, Bin Tian, Dangsheng Li, GangWang*. The Mediator MED23 plays opposing roles in directing smooth muscle cell and adipocyte differentiation. Genes & Dev 2012; 26(19):2192-2205. (Highlighted by Nature Asia – AIMBN) Xu Yang, Meng Zhao, Min Xia, Yuting Liu, Jun Yan, HongbinJi, and Gang Wang*. Selective Requirement for Mediator MED23 in Ras-active Lung Cancer. PNAS 2012; 109(41):E2813-22. (Highlighted by Nature Asia – AIMBN) Yan Huang, Wencheng Li, Xiao Yao, Qijiang Lin, Jingwen Yin, Yan Liang, Monika Heiner, Bin Tian, Jingyi Hui, and Gang Wang*. Mediator Complex Regulates Alternative mRNA Processing via the MED23 Subunit. Mol Cell 2012; 45:459-469. (Cover story with commentary; Highlighted in Faculty 1000) Wei Wang, Lu Huang, Yan Huang, Jingwen Yin, Arnold J. Berk, Jeffrey Friedman, Gang Wang*. Mediator MED23 links insulin signaling to the adipogenesis transcription cascade. Dev Cell 2009; 16:764-771.