个人简介
王永明博士，复旦大学生命科学学院教授。2001年本科毕业于兰州大学；2004硕士毕业于东北师范大学，导师为刘宝教授。2005-2010年在德国马克思戴尔布吕克分子医学中心（MDC）师从Zsuzsanna Izsvak教授研究睡美人转座子，取得了柏林自由大学博士学位。2010-2013年在斯坦福大学师从Joseph Wu教授做博士后，用基因编辑技术和多能干细胞技术研究心肌病。
获奖情况
2015年获得年国家青年人才项目
2020年获得中国技术市场协会金桥奖
2020年获得金龙鱼合成生物学学者奖
2022年获得国家高层次领军人才项目
近期论文
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Man Qi#, Shuhong Ma#, Jingtong Liu#, Xujie Liu, Jingjing Wei, Wen-Jing Lu, Siyao Zhang, Yun Chang, Yongshuai Zhang, Kejia Zhong, Yuting Yan, Min Zhu, Yabing Song, Yundai Chen, Guoliang Hao, Jianbing Wang, Li Wang, Andrew S Lee, Xiangbo Chen*, Yongming Wang*, Feng Lan*. In vivo base editing of Scn5a rescues type 3 long QT syndrome in mice. Circulation. 2023 Nov 15.
Chengdong Zhang#, Yuan Yang#, Tao Qi, Yuening Zhang, Linghui Hou, Jingjing Wei, Jingcheng Yang, Leming Shi, Sang-Ging Ong, Hongyan Wang, Hui Wang*, Bo Yu*, Yongming Wang*. Prediction of base editor off-targets by deep learning. Nature communications. 2023 Sep 2;14(1):5358.
Siqi Gao1#, Yao Wang1#, Tao Qi#, Jingjing Wei, Ziying Hu, Jingtong Liu, Shuna Sun*, Huihui Liu*, Yongming Wang*. Genome editing with natural and engineered CjCas9 orthologs. Molecular Therapy. 2023 Apr 5; 31(4): 1177-1187.
Yao Wang, Tao Qi, Jingtong Liu, Yuan Yang, Ziwen Wang, Ying Wang, Tianyi Wang, Miaomiao Li, Mingqing Li, Daru Lu, Alex Chia Yu Chang, Li Yang, Song Gao, Yongming Wang*, Feng Lan*. A highly specific CRISPR-Cas12j nuclease enables allele-specific genome editing. Science Advances. 2023 Feb 10;9(6):eabo6405.
Shuai Wang#, Chen Tao#, Huilin Mao, Linghui Hou, Yao Wang, Tao Qi, Yuan Yang, Sang-Ging Ong, Shijun Hu*, Renjie Chai*, Yongming Wang*. Identification of SaCas9 orthologs containing a conserved serine residue that determines simple NNGG PAM recognition. PLoS Biology. 2022 Nov 30;20(11): e3001897.
Jingjing Wei, Linghui Hou, Jingtong Liu, Ziwen Wang, Siqi Gao, Tao Qi, Song Gao, Shuna Sun*, Yongming Wang*. Closelyrelated type II-C Cas9 orthologs recognize diverse PAMs. eLife. 2022 Aug 12;11:e77825.
Shuai Wang, Huilin Mao, Linghui Hou, Ziying Hu, Yao Wang, Tao Qi, Chen Tao, Yuan Yang, Chengdong Zhang, Miaomiao Li, Huihui Liu, Shijun Hu, Renjie Chai*, Yongming Wang*. Compact SchCas9 Recognizes the Simple NNGR PAM. Advanced Science. 2022 Feb;9(4):e2104789.
Shuhong Ma#, Wenjian Jiang#, Xujie Liu#, Wen-Jing Lu, Tao Qi, Jingjing Wei, Fujian Wu, Yun Chang, Siyao Zhang, Yabing Song, Rui Bai, Jianbing Wang, Andrew S. Lee, Hongjia Zhang*, Yongming Wang*, Feng Lan*. Efficient Correction of a Hypertrophic Cardiomyopathy Mutation by ABEmax-NG. Circulation Research. 2021 Oct 29;129(10):895-908.
Ziying Hu #, Chengdong Zhang#, Shuai Wang, Siqi Gao, Jingjing Wei, Miaomiao Li, Linghui Hou, Huilin Mao, Yanyan Wei, Tao Qi, Hongmao Liu, Dong Liu, Feng Lan, Daru Lu, Hongyan Wang*, Jixi Li*, Yongming Wang*. Discovery and engineering of small SlugCas9 with broad targeting range and high specificity and activity. Nucleic Acids Research. 2021 Apr 19 ;49(7): 4008-4019.
Daqi Wang#, Chengdong Zhang#, Bei Wang, Bin Li, Qiang Wang, Dong Liu, Hongyan Wang, Yan Zhou, Leming Shi, Feng Lan*, Yongming Wang*. Optimized CRISPR guide RNA design for two high-fidelity Cas9 variants by deep learning. Nature Communications. 2019 Sep 19;10(1):4284.
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