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个人简介

国家杰出青年科学基金获得者、英国皇家化学会会士、复旦大学特聘教授、国家重点研发计划项目首席。1986年获西北轻工业学院(现陕西科技大学)学士、1994年获伦敦大学博士学位。1992-2005年先后在英国BBSRC食品研究所、帝国理工学院生物医学部任Senior Scientist等职。2005-14年先后任中科院武汉物数所研究员、博导、研究部副主任、中科院生物磁共振分析重点实验室创建主任。2014年加盟复旦大学生命科学学院。曾任英国NHS、科技部973及蛋白质重大计划等评审专家、J Proteome Res编委。在Nature及PNAS等上发表SCI论文210余篇,被引1.2万余次(h指数~63)。获批发明专利6项。部分工作被Science、Nature等作为“研究亮点”专文评述。现任国际实验核磁共振大会(ENC)执委、中国生物物理学会代谢组学分会会长、自由基生物学及医学分会常务理事、生物磁共振专委会委员,中国抗癌协会肿瘤代谢专委会常务理事,中国营养学会基础营养学分会理事,Metabolomics、Curr Metabolomics、Arch Pharm和《基础医学与临床》等编委,Nutrition & Metabolism及Phenomics等副主编。 获奖情况 英国皇家化学会会士(2005) 国家杰出青年科学基金(2008) 王天眷波谱学奖(2010) 武汉市优秀科技工作者(2011) “精准医学研究”国家重点研发计划项目首席(2017-2020) “生物前沿技术”国家重点研发计划项目首席(2022-2027)

研究领域

发展并应用代谢组学新技术,研究疾病发生发展的机制。包括代谢组学与脂质组学新技术体系、疾病发生发展和有效干预的分子机制、宿主代谢与肠道菌群相互作用机制与健康。本人研究代谢物结构功能及代谢组学30余年,发展高通量超灵敏代谢组学、代谢组与转录组/蛋白质组/微生物组数据整合分析等技术并用以研究疾病发生发展机制。曾主持国家杰出青年科学基金、精准医学与生物前沿技术等国家重点研发计划、国家自然科学基金、973课题等项目多项。现承担“生物前沿技术”国家重点研发计划、国家创新群体、上海市级重大专项等项目。

近期论文

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Y. B. Feng, et al, “Anopheline mosquitoes are protected against parasite infection by tryptophan catabolism in gut microbiota”, Nat Microbiol, 7:707-715, 2022.【IF~31】 Z. M. Hou, et al, “Inhibiting 3bHSD1 to eliminate the oncogenic effects of progesterone in prostate cancer”, Cell Rep Med, 3:100561, 2022.【IF~17】 J. H. Liu, et al, “Simultaneous quantification of 70 elements in biofluids within 5 min using inductively coupled plasma mass spectrometry to reveal elementomic phenotypes of healthy Chinese adults”, Talanta, 238:123720, 2022.【IF~6.6】 Q. Y. Hu, et al, “Quantitative structure-retention relationship for reliable metabolite identification and quantification in metabolomics using ion-pair reversed-phase chromatography coupled with tandem mass spectrometry”, Talanta, 238:123059, 2022.【IF~6.6】 M. F. Xia, et al, “NAFLD-related gene polymorphisms and all-cause and cause-specific mortality in an Asian population: the Shanghai Changfeng Study”, Aliment Pharm Ther, 55:705-21, 2022【IF~9.5】 M. F. Xia, et al, “Insights into contribution of genetic variants towards the susceptibility of MAFLD revealed by the NMR_based lipoprotein profiling”, J Hepatol, 74:974-977, 2021.【IF~30】 Y. Xu, et al, “Asparagine reinforces mTORC1 signaling to boost thermogenesis and glycolysis in adipose tissues”, EMBO J, e108069, 2021.【IF~14】 M. Wang, et al, “Glucose-mediated proliferation of a gut commensal bacterium promotes Plasmodium infection by increasing mosquito midgut pH”, Cell Rep, 35:108992, 2021【IF~10】 R. Loo, et al, “A feasibility study of metabolic phenotyping of dried blood spot specimens in rural Chinese women exposed to household air pollution”, J Expo Sci Env Epid, 31:328, 2021【IF~6.4】 Y. P. An, et al, “Development and validation of an improved probabilistic quotient normalization method for LC/MS- and NMR-based metabonomic analysis”, Chin Chem Lett, 31:1827, 2020.【IF~8.5】 J. Xue, et al, “A vitamin-C-derived DNA modification catalysed by an algal TET homologue”, Nature, 569:581–585, 2019【IF~69】 H. Lin, et al, “Alterations of bile acids and gut microbiota in obesity induced by high fat diet in rat model”, JAFC, 67:3624-32. 2019.【IF~5.9; 高被引, 年均20余次】 J. Gou, et al, “Discovery of a non-stereoselective cytochrome P450 catalyzing either 8α- or 8β-hydroxylation of germacrene A acid from the Chinese medicinal plant, Inula hupehensis”, Plant J, 93:92-106, 2018.【IF~7.1】 F. Chen, et al, “Combined metabonomic and quantitative RT-PCR analyses revealed metabolic reprogramming associated with Fusarium graminearum resistance in transgenic Arabidopsis thaliana”, Front Plant Sci, 8:2177, 2018.【IF~6.6】 L. Zhang, et al, “Metabolomics reveals that dietary ferulic acid and quercetin modulate metabolic homeostasis in rats”, J Agric Food Chem, 66: 1723?1731, 2018. 【IF~5.9】 C. Liu, et al, Dynamic metabolic responses of brown planthoppers towards susceptible and resistant rice plants, Plant Biotechnol J, 15:1346, 2017.【IF~13】 Q. Wan, et al, Quantitative 13C traces of glucose fate in hepatitis B virus infected hepatocytes, Anal Chem, 89:3293–3299, 2017【IF~8】 H. Li, et al,Decreased glutathione biosynthesis contributes to EGFR T790M-driven erlotinib resistance in non-small cell lung cancer, Cell Discov, 2:16031, 2016.【IF~38】 L. Sun, et al, cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions, Cell Res, 25:429, 2015.【IF~46】 M. Li, et al, “Human symbiotic gut microbes specifically modulate metabolic phenotypes”, PNAS, 105:2117-2122, 2008.【IF~12.8; 高被引, 年均被引>50次】

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