个人简介
本科毕业于复旦大学,博士毕业于美国宾夕法尼亚大学,其后于国际领军药企任总裁博士后。获国家杰出青年基金、国家优秀青年基金、国家原创项目基金、英国医学院牛顿高级学者等项目资助。获科学探索奖(Xplorer Prize)、教育部青年科学奖、吴瑞纪念基金会顾孝诚奖、上海市青年科技英才等。主要项目研究神经退行性疾病机制,基于化学生物学、生物物理等交叉学科手段建立原创药物发现平台。
近期论文
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Li Z, et.al, Ding Y*, Fei Y*, Lu B*, “Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds”, Nature. 2019, 575(7781):203-209 (Selected as one of the “10 remarkable papers from 2019”)
Song H, et.al, Lu B, “Targeting Gpr52 lowers mutant HTT levels and rescues Huntington’s disease-associated phenotypes”, Brain. 2018, 141(6):1782-1798
Yu M, Fu Y, Liang Y, et.al, Lu B, “Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington’s disease models.” Cell Research. 2017 Dec;27(12):1441-1465.
Fu Y, Wu P, Pan Y, Sun X, Difiglia M, Lu B, "A Toxic Mutant Huntingtin Species Is Resistant to Selective Autophagy." Nature Chemical Biology. 2017 Nov;13(11):1152-1154.
Yao Y, Cui X, Al-Ramah I, Sun X, Li B, Hou J, Difiglia M, Palacino J,Wu Z, Ma L, Botas J, Boxun Lu,“A Striatal-enriched Intronic GPCR Modulates Huntingtin Levels and Toxicity.”eLife. 2015 Mar; 4:e05449