蒯本科 - 复旦大学 - 生命科学学院

个人简介

复旦大学生命科学学院教授、生物化学与分子生物学专业博士生导师。英国威尔士大学生物工程学博士，英国草地环境研究所（BBSRC-IGER）博士后，美国杜克大学（Duke）访问教授。中国植物生理与分子生物学学会成熟与衰老专业委员会主任委员，上海市植物生理与分子生物学学会副理事长，上海市农业工程学会副理事长。本人领导的实验室在国际上率先克隆了绿色器官衰老进程中叶绿素降解的第一个关键酶基因NYEs/SGRs（孟德尔豌豆和大豆绿粒性状的调控因子）和第二个关键酶基因CRN1/PPH。揭示了主要植物激素、光信号和甲基化调控叶绿素降解和叶片衰老的多个关键调控路径。获奖情况 (Awards) 主持培育出了衰老叶片不黄化和抵抗锈病的草坪草新品种“滞绿1号”，获得上海市优秀发明选拔赛一等奖（2004年）曾获上海市优秀青年教师和曙光学者称号曾被委任为上海市科委重大攻关研究计划《重要转基因作物安全性研究》首席专家

研究领域

1）蔬果成熟过程中营养成分/风味物质形成的调控机理主要探索番茄、水果玉米等生食蔬果成熟过程中营养成分/风味物质形成的协同调控机理。生食蔬果是健康营养物质的主要来源之一，长期以提高产量与效益为主的品种改良使得其营养品质和风味口感大大降低。我们以遗传学、分子生物学和代谢组学等手段研究其营养成分/风味物质形成的遗传基础和分子机理，并探索其改良路径。 2）绿色器官成熟衰老进程中叶绿素降解的调控机理重点研究主要植物激素、环境因子和表观遗传调控绿色器官成熟衰老进程中叶绿素降解的特异性机理及其关联调控关系。我们借助于拟南芥模式体系，利用分子生物学、基因组学和生物信息学等技术手段，系统研究了绿色器官衰老的关键生化事件---叶绿素降解启动的信号与关键调控节点，并解析了与叶片衰老进程关联调控的网络关系。 3）叶片衰老与抗逆性之间的协同调控机理试图阐释叶片衰老与抗旱性/抗病性之间的协同调控关系。植物的自养属性和固着生活方式决定了其叶片在营养运筹方面的双重功能：发育成熟的叶片主营光合同化功能，而在遭遇逆境胁迫启动衰老时叶片则营营养物质的再动员功能。叶片衰老的适时启动，使得其同化能力和营养物质再动员能力双双达到最大化，不仅能够保障植株生长发育的竞争优势，也能够有助于作物产量和品质的提高。

近期论文

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Wang X, Gao J, Gao S, Song Y, Yang Z, Kuai B* (2019) The H3K27me3 demethylase REF6 promotes leaf senescence through directly activating major senescence regulatory and functional genes in Arabidopsis. PLoS Genet. 15(4): e1008068. https:// i.org/10.1371/journal.pgen.1008068 Xie Z, Wu S, Chen J, Zhu X, Zhou X, H?rtensteiner S, Ren G*, Kuai B* (2019) The C-terminal cysteine-rich motif of NYE1/SGR1 is indispensable for its function in chlorophyll degradation in Arabidopsis. Plant Mol.Biol. https://doi.org/10.1007/s11103-019-00902-1 Li Z, Wu S, Chen J, Wang X, Gao J, Ren G*, Kuai B* (2017) NYEs/SGRs-mediated chlorophyll degradation is critical for detoxification during seed maturation in Arabidopsis. Plant J. 92:650-661 Chen J, Zhu X, Ren J, Qiu K, Li Z, Xie Z, Gao J, Zhou X*, Kuai B* (2017) Suppressor of Overexpression of CO 1 negatively regulates dark-induced leaf degreening and senescence by directly repressing pheophytinase and other senescence-associated genes in Arabidopsis. Plant Physiol. 173(3):1881-1891 Gao S, Gao J, Zhu X, Song Y, Li Z, Ren G, Zhou X*, Kuai B* (2016) ABF2, ABF3, and ABF4 promote ABA-mediated chlorophyll degradation and leaf senescence by transcriptional activation of chlorophyll catabolic genes and senescence-associated genes in Arabidopsis. Mol. Plant 9(9):1272-1285 Wu S, Li Z, Yang L, Xie Z, Chen J, Zhang W, Liu T, Gao S, Gao J, Zhu Y, Xin J, Ren G*, Kuai B* (2016) NON-YELLOWING2 (NYE2), a close paralog of NYE1, plays a positive role in chlorophyll degradation in Arabidopsis. Mol. Plant 9(4):624-627 Li Z, Wang X, Chen J, Gao J, Zhou X*, Kuai B* (2016) CCX1, a putative cation / Ca2+ exchanger, participates in the regulation of reactive oxygen species homeostasis and leaf senescence. Plant and Cell Physiol. 57 (12):2611-2619 Li S, Gao J, Yao L, Ren G, Zhu X, Gao S, Qiu K, Zhou X*, Kuai B* (2016) The role of ANAC072 in the regulation of chlorophyll degradation during age- and dark-induced leaf senescence. Plant Cell Rep. 35 (8):1729-1741 Zhu X, Chen J, Xie Z, Gao J, Ren G, Gao S, Zhou X*, Kuai B* (2015) Jasmonic acid promotes degreening via MYC2/3/4- and ANAC019/055/072-mediated regulation of major chlorophyll catabolic genes. Plant J. 84:597-610 Qiu K, Li Z, Yang Z, Chen J, Wu S, Zhu X, Gao S, Gao J, Ren G, Kuai B*, Zhou X* (2015) EIN3 and ORE1 accelerate degreening during ethylene-mediated leaf senescence by directly activating chlorophyll catabolic genes in Arabidopsis. PLoS Genet. 11(7): e1005399 doi:10.1371/journal.pgen.1005399 Wang X, Gao J, Zhu Z, Dong X, Wang X, Ren G, Zhou X*, Kuai B*（2015） TCP transcription factors are critical for the coordinated regulation of ISOCHORISMATE SYNTHASE 1 expression in Arabidopsis thaliana. Plant J. 82:151-162 Song Y, Yang C, Gao S, Zhang W, Li L*, Kuai B*(2014) Age-Triggered and Dark-Induced leaf senescence require the bHLH transcription factors PIF3, 4 and 5. Mol. Plant 7:1776-1787 Ren G, Zhou Q, Wu S, Zhang Y, Zhang L, Huang J, Sun Z, Kuai B*（2010）Reverse genetic identification of CRN1 and its distinctive role in chlorophyll degradation in Arabidopsis. J. Integr. Plant Biol. 52 (5):496-504 Ren G, An K, Liao Y, Zhou X, Cao Y, Zhao H, Ge X, Kuai B*（2007） Identification of a novel chloroplast protein AtNYE1 regulating chlorophyll degradation during leaf senescence in Arabidopsis. Plant Physiol. 144:1429-1441 综述与评述 Kuai B, Chen J, H?rtensteiner S* (2018) The biochemistry and molecular biology of chlorophyll breakdown, J EXP BOT. 69(4):751-767 Zhu X, Chen J, Qiu K, Kuai B* (2017) Phytohormone and light regulation of chlorophyll degradation. Front Plant Sci, doi: 10.3389/fpls.2017.01911 Chen J, Ren G, Kuai B* (2016) The Mystery of Mendel's stay-green: magnesium stays chelated in chlorophylls. Mol. Plant 9(12):1556-1558