Jiang, Hao - University of Virginia - Department of Biochemistry and Molecular Genetics

个人简介

PhD, Johns Hopkins School of Medicine BS, Tsinghua University Postdoc, Rockefeller University

研究领域

Regulation of stem cell function and tumorigenesis by epigenetics and biomolecular condensation (phase separation)

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Yang Z, Jiang H, A chromatin perspective on metabolic and genotoxic impacts on hematopoietic stem and progenitor cells., 2020; Cellular and molecular life sciences : CMLS. () . PMID: 32318759 Jiang H, The complex activities of the SET1/MLL complex core subunits in development and disease., 2020; Biochimica et biophysica acta. Gene regulatory mechanisms. 1863(7) 194560. PMID: 32302696 | PMCID: PMC7236065 Li W, Hu J, Shi B, Palomba F, Digman MA., Gratton Enrico, Jiang H, Biophysical properties of AKAP95 protein condensates regulate splicing and tumorigenesis, 2020; Nature Cell Biology (also as BioRxiv 536839). () . PMID: Yang Z, Shah K, Khodadadi-Jamayran A, Jiang H, Control of Hematopoietic Stem and Progenitor Cell Function through Epigenetic Regulation of Energy Metabolism and Genome Integrity., 2019; Stem cell reports. 13(1) 61-75. PMID: 31231026 | PMCID: PMC6627005 Shah K, King GD, Jiang H, A chromatin modulator sustains self-renewal and enables differentiation of postnatal neural stem and progenitor cells., 2019; Journal of molecular cell biology. () . PMID: 31065682 Shah KK, Whitaker RH, Busby T, Hu J, Shi B, Wang Z, Zang C, Placzek WJ, Jiang H, Specific inhibition of DPY30 activity by ASH2L-derived peptides suppresses blood cancer cell growth., 2019; Experimental cell research. 382(2) 111485. PMID: 31251903 | PMCID: PMC6717027 Yang Z, Shah K, Busby T, Giles K, Khodadadi-Jamayran A, Li W, Jiang H, Hijacking a key chromatin modulator creates epigenetic vulnerability for Myc-driven cancer., 2018; The Journal of clinical investigation. () . PMID: 29870403 Hu J, Khodadadi-Jamayran A, Mao M, Shah K, Yang Z, Nasim MT, Wang Z, Jiang H, AKAP95 regulates splicing through scaffolding RNAs and RNA processing factors., 2016; Nature communications. 7() 13347. PMID: 27824034 | PMCID: PMC5105168 Yang Z, Shah K, Khodadadi-Jamayran A, Jiang H, Dpy30 is critical for maintaining the identity and function of adult hematopoietic stem cells., 2016; The Journal of experimental medicine. 213(11) 2349-2364. PMID: 27647347 | PMCID: PMC5068233 Yang Z, Augustin J, Hu J, Jiang H, Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors., 2015; PloS one. 10(12) e0145336. PMID: 26691508 | PMCID: PMC4686221 Yang Z, Augustin J, Chang C, Hu J, Shah K, Chang CW, Townes T, Jiang H, The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells., 2014; Blood. 124(13) 2025-33. PMID: 25139354 | PMCID: PMC4507038 Jiang H, Lu X, Shimada M, Dou Y, Tang Z, Roeder RG, Regulation of transcription by the MLL2 complex and MLL complex-associated AKAP95., 2013; Nature structural & molecular biology. 20(10) 1156-63. PMID: 23995757 | PMCID: PMC3813012 Jiang H, Shukla A, Wang X, Chen WY, Bernstein BE, Roeder RG, Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains., 2011; Cell. 144(4) 513-25. PMID: 21335234 | PMCID: PMC3572774 Jiang H, Chang FC, Ross AE, Lee J, Nakayama K, Nakayama K, Desiderio S, Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle., 2005; Molecular cell. 18(6) 699-709. PMID: 15949444 Jiang H, Ross AE, Desiderio S, Cell cycle-dependent accumulation in vivo of transposition-competent complexes between recombination signal ends and full-length RAG proteins., 2003; The Journal of biological chemistry. 279(9) 8478-86. PMID: 14660558