研究领域

Chemical Engineering and Technology

The research group “Industrial Biocatalysis” is focused on fundamental aspects of biocatalysis and genetic engineering to understand and predict the basic molecular and structural features that provide or impose industrial process fitness on biocatalytic systems. Research involves biocatalytic aspects of biomass transformation into building blocks for chemical, pharmaceutical, food and energy production. Cores themes are the isolation, characterization and process relevant optimization of novel biocatalysts utilizing modern genomics and proteomics tools. Additionally, we use the comprehensive toolbox of synthetic biology to create process tailored whole cell biocatalysts for transformation of biomass into value adding products. Associated with these efforts is the development of research tools for the utilization and optimization of phototrophic organisms that combine remediation of CO2 greenhouse gas effects with the production of value-adding product streams.

近期论文

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Brück WM, Gibson G, Brück TB. The effect of proteolysis on the induction of cell death by monomeric alpha-lactalbumin (2014) Biochimie 97, 138-143 Bohnen F, Brück TB. A critical review of algae process optimization using design of experiment methodologies (2013) JSM Biotechnol.Bioeng. 1(3), 1015 Sommer B, Garbe D, Brück TB. Catalytic modules in non-natural butanol biosynthesis: Conversion of the key intermediate crotylalcohol to n-butanol via a designed enzyme cascade, (2013) JSM Biotechnol.Bioeng. 1(2), 1010 Sommer B, Garbe D, Schrepfer P, Brück T. Characterization of a highly thermostable ß-hydroxybutyryl CoA dehydrogenase from Clostridium acetobutylicum ATCC 824, (2013) Journal of Molecular Catalysis. B, Enzymatic Volume 98, pp. 138–144 Brück TB, Bohnen F. The Biodiesel Dilemma: A techno- and socioeconomic review of EU legislative actions, (2013) JSM Biotechnol.Bioeng. 1(2), 1009 Görner C, Häuslein I, Schrepfer P, Eisenreich W, Brück TB. Targeted engineering of cyclooctat-9-en-7-ol synthase: A stereospecific access to two new, non-natural fusicoccane-type diterpenes, (2013) Chem.Cat.Chem. 5, pp. 3289–3298 Zhao C, Brück TB, Lercher JA. Catalytic deoxygenation of microalgae oil to green hydrocarbons, (2013) Green Chem 15, 1720-1739 Bis 2012 Guterl JK, Garbe D, Carsten J, Steffler F, Sommer B, Reiße S, Philipp A, Haack M, Rühmann B, Koltermann A, Kettling U, Brück T, Sieber V. Cell-free metabolic engineering: production of chemicals by minimized reaction cascades. (2012) Chem Sus Chem 5, pp. 2165-72 Brück TB, Brück DW. Oxidative metabolism of the anti-cancer agent mitoxantrone by horseradish, lacto-and lignin peroxidase.(2011) Biochimie 93, pp. 217-26 Brück WM, Brück TB, Self WT, Reed JK, Nitecki SS, McCarthy PJ. Comparison of the anaerobic microbiota of deep water Geodia sp. and sandy sediments in the Florida straits, (2010) ISME J 4, pp. 686-699 Ranzer L, Brueck TB, Lopez J, Kerr RG. A new prokaryotic farnesyldiphosphate synthase from the octocoral Eunicea fusca: differential display, inverse PCR, cloning, and characterization, (2009) Mar Biotechnol (NY) 11(1), pp. 62-73 Al-Ghoul M, Brück TB, Lauer-Fields JL, Asirvatham VS, Zapata C, Kerr RG, Fields GB. Comparative proteomic analysis of matched primary and metastatic melanoma cell lines, (2008) J Proteome Res 7(9), pp. 4107-18 Santiago LZ, Brück TB, Brück WB, Kerr RG. The diversity of the bacterial communities associated with the azooxanthellate hexacoral Cirrhipathes leutkeni, (2007) ISME J 1, pp. 654-659 Brück TB, Brück WM, Santiago-Vasquez LZ, McCarthy P, Kerr RG. Diversity of the bacterial communities associated with the azooxanthellate deep water octocorallia Leptogorgia minimata, Iciligorgia schrammi and Swiftia exertia, (2007) Mar Biotech 9, pp. 1-1 Brück TB, Kerr RG. Purification and kinetic properties of elisabethatriene synthase from the coral Pseudopterogorgia elisabethae, (2006). Comp Biochem Physiol B 143, pp. 295-302 Brück TB, Harvey PJ. Proteomics: advances, challenges and frontiers, (2005) The Biomedical Scientist 6, pp. 554-564 Brück TB, Harvey PJ. Oxidation of mitoxantrone by lactoperoxidase (2003) Biochim Biophys Acta 1649, pp. 154-163 Brück TB, Gerini MF, Baciocchi E, Harvey PJ. Oxidation of thioanisole and p-methoxythioanisole by lignin peroxidase: kinetic evidence of a direct reaction between Compound II and a radical cation, (2003) Biochem J 374, pp. 761-766 Brück TB, Harvey PJ. Spectrophotometric investigations with hexa-coordinate ferric lignin peroxidase, (2002) Biochem Biophys. Res. Comm. 297, pp. 406-411 Brück TB, Fielding RJ, Symons MCR, Harvey PJ. Mechanism of nitrite stimulated catalysis by lactoperoxidase, (2001) Eur J Biochem. 268, pp. 3214-3222 Brueck TB, Simpson D, Hoban P, Clayton RN, Farrell WC. Amplification of the Cyclin D1 gene in primary pituitary tumours, (1997) J Endocrinol 155, pp. 20-21