个人简介

Matthias Feige studied biochemistry at the Swiss Federal Institute of Technology (ETHZ) and the Technische Universität München (TUM), where he obtained his PhD in biochemistry. As a postdoctoral fellow at the St. Jude Children’s Research Hospital in Memphis, TN, USA, he expanded his research towards cell biology. In 2014 Matthias Feige was appointed as a Rudolf Mößbauer Tenure Track Professor at the TUM-IAS. From March 2015 on he will head the laboratory for Cellular Protein Biochemistry at the TUM Department of Chemistry (cv).

研究领域

Organic Chemistry and Biochemistry

How do cells control that the proteins they produce possess the correct structure? How is it ensured that defective proteins are recognized and degraded instead of having potentially harmful effects on the organism? Which molecules and mechanisms underlie this molecular quality control? Professor M. Feige (b. 1979) addresses these questions with a particular focus on both secretory and membrane proteins. These protein classes play an important role in the interaction of cells with their environment, e.g. in the human immune system. In Professor Feige’s lab for Cellular Protein Biochemistry a particular emphasis is laid on proteins of direct medical relevance so that insights into the principles of cellular quality control might ultimately be translated into new biomedical and biotechnological applications.

近期论文

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Behnke J1, Feige M1, Hendershot LM* BiP and Its Nucleotide Exchange Factors Grp170 and Sil1: Mechanisms of Action and Biological Functions. J Mol Biol 2015, 427(7):1589-1608. Otero JH1, Lizák B1, Feige MJ, Hendershot LM* Dissection of structural and functional requirements that underlie the interaction of ERdj3 protein with substrates in the endoplasmic reticulum. J Biol Chem 2014, 289(40):27504-12. Feige MJ*, Buchner J* Principles and engineering of antibody folding and assembly. Biochim Biophys Acta 2014, 1844(11):2024-2031. Feige MJ1,*, Gräwert MA1,, Marcinowski M1,, Hennig J1,, Behnke J, Ausländer D, Herold EM, Peschek J, Castro CD, Flajnik M, Hendershot LM, Sattler M, Groll M, Buchner J. The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins. Proc Natl Acad Sci U S A 2014, 111(22):8155-60. Feige MJ*, Hendershot LM* Quality control of integral membrane proteins by assembly-dependent membrane integration. Mol Cell 2013, 51(3):297-309. Hendershot LM*, Feige MJ*, Buchner J* Acidification activates ERp44--a molecular litmus test for protein assembly. Mol Cell 2013, 50(6):779-81. Marcinowski M, Rosam M, Seitz C, Elferich J, Behnke J, Bello C, Feige MJ, Becker CF, Antes I*, Buchner J* Conformational selection in substrate recognition by Hsp70 chaperones. J Mol Biol 2013, 425(3):466-74. Howes J, Shimizu Y, Feige MJ, Hendershot LM* C-terminal mutations destabilize SIL1/BAP and can cause Marinesco-Sjögren syndrome. J Biol Chem 2012, 287(11):8552-60.