个人简介

Director, W. M. Keck Center for RNA-Mediated Materials Synthesis: 2005-2007 Postdoctoral Fellow, Pennsylvania State University: 1995-1997 Graduate Research/Teaching Assistant, Colorado State University: 1990-1994

研究领域

Bioanalytical Chemistry Nanomedicine

The Feldheim lab is developing new reagents and methods for the diagnosis and treatment of diseases such as multi-drug resistant M. tuberculosis, K. pneumoniae, HIV, and lung cancer. Our methods are unique in that they exploit interactions between nanometer-sized inorganic particles and cellular biomolecules (e.g., proteins, oligosaccharides, DNA). Please visit our Research page to learn more about our projects.

近期论文

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J. Bresee, C. M. Bond, R. J. Worthington, C. Smith, J. Gifford, C. A. Simpson, G. Kim, C. J. Carter, G. Wang, J. Hartman, N. A. Osbaugh, R. Shoemaker, C. Melander, D. L. Feldheim "Nanoscale Structure-Activity Relationships, Mode of Action, and Biocompatibility of Gold Nanoparticle Antibiotics" J. Am. Chem. Soc. 2014, dx.doi.org/10.1021/ja408505n. C. Smith, C. A. Simpson, G. Kim, C. J. Carter, D. L. Feldheim “Gastrointestinal Bioavailability of 2.0 nm Diameter Gold Nanoparticles” ACS Nano, 2013, http://dx.doi.org/10.1021/nn305930e. C. A. Simpson, K. J. Salleng, D. E. Cliffel, D. L. Feldheim "In vivo Toxicity, Biodistribution, and Clearance of Glutathione-Coated Gold Nanoparticles" Nanomedicine, 2013, 9, 257-263. J. Bresee, K. E. Maier, A. Boncella, C. Melander, D. L. Feldheim, "Growth Inhibition of Staphyloccocus aureus by Mixed Monolayer Coated Gold Nanoparticles", Small, 2011, 7, No. 14, 2027–2031. J. Rouge, B. E. Eaton, D. L. Feldheim, “Biomolecules in the Synthesis and Assembly of Materials for Energy Applications”, Energy & Environmental Science, 2011, 4, 398. C. J. Carter, A. Owczarek, D. L. Feldheim "Methods for Isolating RNA Sequences Capable of Binding to or Mediating the Formation of Materials", in Bionanotechnology Protocols, Edited by Sandra Rosenthal and David Wright, Humana Press Inc. New Jersey, 2010, in press. J. Bresee, K. E. Maier, C. Melander, and D. L. Feldheim "Identification of Antibiotics Using Small Molecule Variable Ligand Display on Gold Nanocrystals" Chemical Communications, 2010, DOI: 10.1039/C0CC02663H. J. L. Rouge, C. J. Ackerson, D. L. Feldheim and B. E. Eaton "Cooperativity Between Two Selected RNA Pdases in the Synthesis of Pd Nanoparticles", J. Mater. Chem., 2010, 20, 8394 - 8398. C. J. Carter, C. J. Ackerson, D. L. Feldheim "Unusual Reactivity of a Ag Mineralizing Peptide" ACS Nano, 2010, 4, 3883. C. J. Carter, M. Dolska, C. J. Ackerson, B. E. Eaton, Daniel L. Feldheim "In Vitro Selection of RNA Sequences Capable of Mediating the Formation of Iron Oxide Nanoparticles" Journal of Materials Chemistry 2009, 19, 8320. D. H. McAdams, S. P. Cape, R. E. Sievers, R. A. Kudgus, Daniel L. Feldheim, et al. “Myo-Inositol as a Stabilizing Excipient for Inhaled Dry Aerosol Vaccines and Pharmaceuticals” Respiratory Drug Delivery Europe, 2009, 2, 399-404. G. Smith, C. J. Ackerson, K. J. Baustian, and Daniel L. Feldheim “Metal Oxide Nanoparticle Formation by Serine and Cysteine Proteases”, 2009, Journal of Materials Chemistry, 2009, 19, 8299. M. C. Bowman, E. T. Ballard, C. J. Ackerson, J. D’Antonio, Daniel L. Feldheim. D. Margolis, C. Melander “Inhibition of HIV Fusion with Multivalent Gold Nanoparticles” J. Am. Chem. Soc. 2008, 130, 6896. S. Kim, J. J. DeYoreo, Bruce E. Eaton, Daniel L. Feldheim, et al. “Scanning Probe-Based Fabrication of 3D Nanostructures Via Affinity Templates, Functional RNA, and Meniscus-Mediated Surface Remodeling” Scanning, 2008, 30, 159. Daniel L. Feldheim, Bruce E. Eaton “Selection of Biomolecules Capable of Mediating the Formation of Materials” ACS Nano, 2007, 1, 154. J. Ryan, M. Speight, W. Overton, W. Robarge, L. Loo, Daniel L. Feldheim “Cellular Uptake of Gold Nanoparticles Passivated with BSA-SV40 Large T Antigen Conjugates” Analytical Chemistry 2007, 79, 9150. Y. Liu, M. K. Shipton, J. Ryan, Daniel L. Feldheim “Synthesis, Stability and Cellular Internalization of Gold Nanoparticles Containing Mixed Peptide-Poly(Ethyleneglycol) Monolayers” Anal. Chem. 2007, 79, 2221. Daniel L. Feldheim “The New Face of Catalysis”, Science 2007, 316, 699. W. Zhang, T. E. Ballard, A. Tkachenko, V. Burns, Daniel L. Feldheim, Christian Melander “Mimicking the Biological Activity of Diazobenzo[b]fluorine Natural Products with Electronically Tuned Diazofluorene Analogs” Bioorganic and Medicinal Chemistry Letters 2006, 16, 5148. Chiamaka Agbasi-Porter, Jessica Ryman-Rasmussen, Daniel L. Feldheim “Transcription Inhibition Using Oligonucleotide-Modified Gold Nanoparticles” Bioconjugate Chem. 2006, 17(5), 1178.