个人简介

Oct 2009 Dr. rer. nat. Technische Universität München, Germany Aug 2003 Diploma in Biochemistry, Universität Bayreuth, Germany 1998-2003 Study of Biochemistry, Universität Bayreuth, Germany and Stockholm University, Sweden

研究领域

Organic Chemistry and Biochemistry

Our research is focussed on nuclear magnetic resonance (NMR) spectroscopy of membrane proteins. This protein class is essential for signal transduction and the transfer of proteins and small molecules across the biological membrane barrier. The key to understanding these processes is to study these systems in a native environment provided by a phospholipid bilayer. These membrane mimics are being developed and established in the lab and subsequently applied to biologically interesting systems like mitochondrial membrane proteins, G-protein coupled receptors (GPCRs) and their associated G-proteins, which are involved in metabolic diseases, neurological disorders and cancer. We are investigating the structure, dynamics and molecular interactions between membrane proteins and their partners using mainly multidimensional NMR spectroscopy, but also electron microscopy, X-ray crystallography and a variety of other biophysical and biochemical methods.

近期论文

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Hagn F, and Wagner G, Structure refinement and membrane positioning of selectively labeled OmpX in phospholipid nanodiscs, J Biomol NMR (2014) epub ahead of print Linser R, Gelev V, Hagn F, Arthanari H, Hyberts S, and Wagner G, Selective methyl labeling of eukaryotic membrane proteins using cell-free expression, J Am Chem Soc 136 (2014) 11308-10 Etzkorn M, Raschle, T, Hagn, F, Gelev V, Rice, AJ, Walz T, and Wagner G, Structural Insights into Cell-Free Expressed Bacteriorhodopsin in Different Soluble Membrane Mimetics. Structure 21 (2013) 394-401 Hagn F, Etzkorn M, Raschle T, and Wagner G, Optimized Phospholipid Bilayer Nanodiscs For High-Resolution Structure Determination of Membrane Proteins. J Am Chem Soc, 135 (2013) 1919-1925 Demmer O, Frank AO, Hagn F, Schottelius M, Marinelli L, Cosconati S, Brack-Werner R, Kremb S, Wester HJ, and Kessler H, A Conformationally Frozen Peptoid Boosts CXCR4 Affinity and Anti-HIV Activity, Angew Chem Int Ed Engl. 32 (2012) 8110-8113 Schmid A.B, Lagleder S, Gräwert MA, Röhl A, Hagn F, Wandinger SK, Cox MB, Demmer O, Richter K, Groll M, Kessler H, and Buchner J, The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop. EMBO J, 31 (2012) 1506-1517 Hagn F*, Lagleder S*, Retzlaff M*, Rohrberg J, Richter, K, Buchner J and Kessler H, Structural analysis of the interaction of the heat shock protein 90 with the tumor suppressor protein p53. Nat Struct Mol Biol, 18 (2011) 1086-1093 Knöll R, Linke WA, Zou P, Miocic S, Kostin S, Buyandelger B, Ku CH, Neef S, Bug M, Schäfer K, Knöll G, Felkin LE, Wessels J, Toischer K, Hagn F, Kessler H, Didié M, Quentin T, Maier LS, Teucher N, Unsöld B, Schmidt A, Birks EJ, Gunkel S, Lang P, Granzier H, Zimmermann WH, Field LJ, Faulkner G, Dobbelstein M, Barton PJ, Sattler M, Wilmanns M, Chien KR, Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart. Circ Res 16 (2011) 758-69 Hagn F, Thamm C, Scheibel T, and Kessler H, pH Dependent Dimerisation and Salt Dependent Stabilisation of the N-terminal Domain of Spider Dragline Silk - Implications for Fibre Formation, Angew Chem Int Ed Engl. 50 (2011), 310-313 Rudolph B, Welker S, Frenzel E, Hagn F, Liebisch G, Schmitz G, Scheuring J, Weinkauf S, Haslbeck M, Kessler H, and Buchner J, Hsp12 is an intrinsically unfolded stress protein which folds upon membrane association and modulates membrane function. Mol Cell 39 (2010), 507-520 Hagn F, Eisoldt L, Hardy JG, Vendrely C, Coles M, Scheibel T, and Kessler H, A conserved spider silk domain acts as molecular switch that controls fibre assembly, Nature 465 (2010), 239-242 Hagn F, Klein C, Demmer O, Marchenko N, Vaseva A, Moll UM, and Kessler H, BclxL changes conformation upon binding to wild-type but not mutant p53 DNA binding domain, J Biol Chem. 285 (2010), 3439-3450 Retzlaff M.*, Hagn F.*, Mitschke L, Hessling M, Gugel F, Kessler H, Richter K and Buchner J, Asymmetric activation of the Hsp90 dimer by its co-chaperone Aha1, Mol Cell 37 (2010), 344-354