个人简介

2011 - 2014 Research Group Leader at the Kekulé-Institute of Organic Chemistry and Biochemistry, University of Bonn 2008 - 2010 Postdoctoral work with Prof. Moore at the Scripps Institution of Oceanography, UC San Diego 2005 - 2008 PhD thesis with Prof. Bringmann, University of Würzburg 1998 - 2004 Undergraduate studies in Chemistry, University of Würzburg

研究领域

Organic Chemistry and Biochemistry

Professor Tobias Gulder (b. 1978) is interested in the structure, biosynthesis and synthesis of bacterial natural products. This includes the elucidation of new biosynthetic transformations and their application to the biocatalytic synthesis of natural products as well as the manipulation of biosynthetic pathways to generate new molecular structures. This is achieved by combining organic synthesis, chemical analytics, biochemical, and biomolecular methods.

近期论文

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C. Greunke, J. Antosch, T.A.M. Gulder; Promiscuous Hydroxylases for the Functionalization of Polycyclic Tetramate Macrolactams - Conversion of Ikarugamycin to Butremycin; Chem. Commun. 2015, DOI: 10.1039/C5CC00843C. H. Aldemir, S. Kohlhepp, T. Gulder, T.A.M. Gulder; On the Structure of a Putative Fluorinated Natural Product from Streptomyces sp. TC1; J. Nat. Prod. 2014, 77, 2331-2334. T. Gulder, T.A.M. Gulder; Chemistry in Stereo: the 49th Bürgenstock Conference; Angew. Chem. Int. Ed. 2014, 53, 9418–9420. H. Aldemir, R. Richarz, T.A.M. Gulder; The Biocatalytic Repertoire of Natural Biaryl Formation; Angew. Chem. Int. Ed. 2014, 53, 8286-8293. J. Antosch, F. Schaefers, T.A.M. Gulder; Heterologous Reconstitution of Ikarugamycin Biosynthesis in E. coli; Angew. Chem. Int. Ed. 2014, 53, 3011-3014. T. Gulder, T.A.M. Gulder; Biosynthese im Reagenzglas; Nachr. Chem. 2014, 62, 1081-1084. T. Gulder, T.A.M. Gulder; Hydrofunktionalisierung mit unüblicher Regioselektivität; Nachr. Chem. 2014, 62, 869-872. T. Gulder, T.A.M. Gulder; Ein Sesquiterpen gegen das Vergessen; Nachr. Chem. 2014, 62, 765-768. T. Gulder, T.A.M. Gulder; H als Abgangsgruppe; Nachr. Chem. 2014, 62, 534-537. T. Gulder, T.A.M. Gulder; Enantioselektive Fluorocyclisierungen; Nachr. Chem. 2014, 62, 39-42. T.A.M. Gulder, S. Neff, T. Schütz, T. Winkler, R. Gees, B. Böhlendorf; The Myxocoumarins A and B from Stigmatella aurantiaca strain MYX-030; Beilstein J. Org. Chem. 2013, 9, 2579. M. Yu, K. Tang, J. Liu, X. Shi, T.A.M. Gulder, X.-H. Zhang; Genome Analysis of Pseudoalteromonas flavipulchra JG1 Reveals Various Survival Advantages in Marine Environment; BMC Genomics 2013, 14, 707.Fulltext A. Kampa, A.N. Gagunashvili, T.A.M. Gulder, C. Daolio, M. Godejohann, V. Miao, J. Piel, Ó.S. Andresson; Metagenomic Natural Product Discovery in Lichen Provides Evidence for a Family of Biosynthetic Pathways in Diverse Symbioses; Proc. Natl. Acad. Sci. USA 2013, DOI: 10.1073/pnas.1305867110. Fulltext T.A.M. Gulder, R. Richarz; Nature’s Chemical Treasure Trove – Biodiversity and Pharmaceuticals in Biodiversity: Concept and Value, Routledge: London, 2013, accepted. T.A.M. Gulder, M.F. Freeman, J. Piel; The Catalytic Diversity of Multimodular Polyketide Synthases: Natural Product Biosynthesis Beyond Textbook Assembly Rules; Top. Curr. Chem. 2013, DOI: 10.1007/128_2010_113. Fulltext T.A.M. Gulder, H. Hong, J. Correa, E. Egereva, J. Wiese, J.F. Imhoff, H. Gross; Isolation, Structure Elucidation and Total Synthesis of Lajollamide A from the Marine Fungus Asteromyces cruciatus; Mar. Drugs 2012, 10, 2912. Fulltext K. Yamanaka, K.S. Ryan, T.A.M. Gulder, C.C. Hughes, B.S. Moore; Flavoenzyme-Catalyzed Atropo-Selective N,C-Bipyrrole Homocoupling in Marinopyrrole Biosynthesis; J. Am. Chem. Soc. 2012, 134, 12434. Fulltext