Tiefenbacher, Konrad - Technische Universität München

个人简介

Konrad received his chemical basic education at the Technical University of Vienna and the University of Texas in Austin. After finishing his diploma thesis in the lab of Prof. Fröhlich, he pursued his interest in total synthesis of biologically active natural products during a Ph.D. in the lab of Prof. Mulzer at the University of Vienna. He then moved to Prof. Rebek’s lab at The Scripps Research Institute in La Jolla to learn about molecular recognition and self-assembly. In 2012 he started his independent career as a Junior professor (W1-position) at the Technical University Munich. In June 2016 he was appointed to a dual tenure track assistant professorship position at the University of Basel and the ETH Zürich, and received tenure in 2020.

研究领域

Our interest is mainly focused on exploring the potential of supramolecular host structures for catalysis. We have focused on molecular capsules as hosts so far, but we have started expanding to other structures recently. The main goal is not only to perform chemistry in these host structures, but to find solutions for current challenges in synthetic organic chemistry that are difficult to address with traditional tools.

近期论文

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Li, T-R.; Huck, F.; Piccini, G. M.; Tiefenbacher, K.* ChemRxiv 2021, Preprint “Hydrogen Bond Synchronized Dual Activation Enables the Unified β-Selective O-Glycosylation Inside a Molecular Capsule” Sokolova, D.; Piccini, G.M.; Tiefenbacher, K.* Angew. Chem. Int. Ed. 2022, Accepted “Enantioselective Tail-to-Head Terpene Cyclizations by Optically Active Hexameric Resorcin[4]arene Capsule Derivatives” Huck, F.; Catti, L.; Reber, G.L.; Tiefenbacher, K.* J. Org. Chem. 2022, 87, 419–428. “Expanding the Protecting Group Scope for the Carbonyl Olefin Metathesis Approach to 2,5-Dihydropyrroles” Pfeuffer-Rooschüz, J.; Schmid, L.; Prescimone, A.; Tiefenbacher, K.* JACS Au 2021, 11, 1885–1891. “Xanthene[n]arenes: Exceptionally Large, Bowl-shaped Macrocyclic Building Blocks Suitable for Self-Assembly” Nemat, S. J.; Tiefenbacher, K.* Org. Lett. 2021, 23, 6861–6865. “Thioderivatives of Resorcin[4]arene and Pyrogallol[4]arene: Are Thiols Tolerated in the Self-Assembly Process?” Sokolova, D.; Tiefenbacher, K.* RSC Adv. 2021, 11, 24607-24612. “Optimized iminium-catalysed 1,4-reductions inside the resorcinarene capsule: achieving >90% ee with proline as catalyst” Hao, X.; Li, T-R.; Chen, H.; Gini, A.; Zhang, X.; Rosset, S.; Mazet, C.; Tiefenbacher, K.; Matile, S.* Chem. Eur. J. 2021, 27, 12215.. “Bioinspired Ether Cyclizations within a π-Basic Capsule Compared to Autocatalysis on π-Acidic Surfaces and Pnictogen-Bonding Catalysts” Nemat, S. J.; Van den Eynden, D.; Deblock, L.; Heilmann, M.; Köster, J. M.; Parvizian, M.; Tiefenbacher, K.*; De Roo, J.* Chem. Commun., 2021, 57, 4694-4697. “Resorcin[4]arene-based multidentate phosphate ligands with superior binding affinity for nanocrystal surfaces” Heilmann, M.; Knezevic, M.; Piccini, G. M.; Tiefenbacher, K.* Org. Biomol. Chem. 2021, 19, 3628-3633. “Understanding the binding properties of phosphorylated glycoluril-derived molecular tweezers and selective nanomolar binding of natural polyamines in aqueous solution” Merget, S.; Catti, L.; Zev, S.; Major, D.T.; Trapp, N.; Tiefenbacher, K.* Chem. Eur. J. 2021, 27, 4447. “Concentration‐dependent Self‐assembly of an Unusually Large Hexameric Hydrogen‐bonded Molecular Cage” Némethová, I.; Syntrivanis, L.-D.; Tiefenbacher, K.* Chimia 2020, 74, 561. “Molecular Capsule Catalysis: Ready to Address Current Challenges in Synthetic Organic Chemistry?” Nemat, S. J.; Jędrzejewska, H.; Prescimone, A.; Szumna, A.; Tiefenbacher, K.* Org. Lett. 2020, 22, 5506. “Catechol[4]arene: The Missing Chiral Member of the Calix[4]arene Family” Knezevic, M.; Heilmann, M.; Piccini, G. M.; Tiefenbacher, K.* Angew. Chem. Int. Ed. 2020, 59, 12387. “Overriding Intrinsic Reactivity in Aliphatic C–H Oxidation: Preferential C3/C4 Oxidation of Aliphatic Ammonium Substrates” Syntrivanis, L.-D.; Némethová, I.; Schmid, D.; Levi, S.; Prescimone, A.; Bissegger, F.; Major, D. T.; Tiefenbacher, K.* J. Am. Chem. Soc. 2020, 142, 5894. “Four-Step Access to the Sesquiterpene Natural Product Presilphiperfolan-1β-ol and Unnatural Derivatives via Supramolecular Catalysis” Bissegger, F. R.; Neuburger, M.; Tiefenbacher, K.* Supramolecular Chemistry 2020 “Scope of the direct trimerisation to C3-symmetric cyclotribenzylene derivatives” Merget, S.; Catti, L.; Piccini, G. M.; Tiefenbacher, K.* J. Am. Chem. Soc. 2020, 142, 4400. “Requirements for Terpene Cyclizations inside the Supramolecular Resorcinarene Capsule: Bound Water and its Protonation Determine the Catalytic Activity” Heilmann, M.; Tiefenbacher, K.* Chem. Eur. J. 2019, 25, 12900. “A Modulated Phosphorylated Glycoluril-Derived Molecular Tweezer for Potent Binding of Aliphatic Diamines” Zhang, Q.; Tiefenbacher, K.* Angew. Chem. Int. Ed. 2019, 58, 12688. “Sesquiterpene Cyclizations inside the Hexameric Resorcinarene Capsule: Total Synthesis of δ‐Selinene and Mechanistic Studies” Zhang, Q.; Catti, L.; Syntrivanis, L.-D.; Tiefenbacher, K.* Nat. Prod. Rep. 2019, 36, 1619. “En route to terpene natural products utilizing supramolecular cyclase mimetics” Pahima, E.; Zhang, Q.; Tiefenbacher, K.; Major, D. T. J. Am. Chem. Soc. 2019, 141, 6234. “Discovering Monoterpene Catalysis Inside Nanocapsules with Multiscale Modeling and Experiments”