个人简介

1987 Diploma in biology, Universität Regensburg 1988–1991 Dissertation, Universität Regensburg 1991­­–1992 Postdoc, NIH, NCI, Bethesda, USA 1992­­–1995 Independent group leader, Universität Regensburg 1995 Habilitation 1995­­–1998 1995 1995-1998 Habilitation Heisenberg fellow, Universität Regensburg since 1998 Professor (chair), Biotechnology, TU München 2003­­–2006 Dean of the Department of Chemistry 2006­­–2010 Member of the Editorial board of ChemBioChem since 2006 Elected panel reviewer for the German Funding Agency Elected member of the advisory board of the German Society for Biochemistry (GBM) Editor Biospektrum

研究领域

Organic Chemistry and Biochemistry

Prof. Buchner (*1960) erforscht der Prinzipien der Strukturbildung von Proteinen und der zellulären Maschinerie der Proteinfaltung, die es auch erlaubt, widrige Umweltbedingungen (wie z.B. hohe Temperaturen) zu überstehen. Neben dem Einblick in fundamentale zelluläre Prozesse liefern diese Untersuchungen auch wichtige Voraussetzungen für die Produktion von Proteinen in biotechnologischen Prozessen, wie z.B. für die Biosynthese von Antikörpern, deren molekulare Grundlagen aufgeklärt werden konnten.

近期论文

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Rehn A.B. & Buchner J. (2015) P23 and Aha1. Subcell Biochem 78, 113 - 131. Zierer B.K., Weiwad M., Rubbelke M., Freiburger L., Fischer G., Lorenz O.R., Sattler M., Richter K. & Buchner J. (2014) Artificial accelerators of the molecular chaperone hsp90 facilitate rate-limiting conformational transitions. Angew Chem Int Ed Engl 53, 12257 - 12262. Röhl A., Tippel F., Bender E., Schmid A.B., Richter K., Madl T. & Buchner J. (2014) Hop/Sti1 phosphorylation inhibits its co-chaperone function. EMBO Rep 12. Paul A., Garcia Y.A., Zierer B.K., Patwardhan C., Gutierrez O., Hildenbrand Z., Harris D.C., Balsiger H.A., Sivils J.C., Johnson J.L., Buchner J., Chadli A. & Cox M.B. (2014) The cochaperone SGTA (Small Glutamine-rich Tetratricopeptide Repeat-containing Protein Alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors. J Biol Chem 289, 15297 - 15308. Nokwe C.N., Zacharias M., Yagi H., Hora M., Reif B., Goto Y. & Buchner J. (2014) A residue-specific shift in stability and amyloidogenicity of antibody variable domains. J Biol Chem 289, 26829 - 26846. Lorenz O.R., Freiburger L., Rutz D.A., Krause M., Zierer B.K., Alvira S., Cuellar J., Valpuesta J.M., Madl T., Sattler M. & Buchner J. (2014) Modulation of the Hsp90 chaperone cycle by a stringent client protein. Mol Cell 53, 941 - 953. Jahn M., Rehn A.B., Pelz B., Hellenkamp B., Richter K., Rief M., Buchner J. & Hugel T. (2014) The charged linker of the molecular chaperone Hsp90 modulates domain contacts and biological function. Proc Natl Acad Sci USA 2, 201414073. Girstmair H. & Buchner J. (2014) Mol Cell 56, 1 - 2. Feige M.J., Grawert M.A., Marcinowski M., Hennig J., Behnke J., Auslander D., Herold E.M., Peschek J., Castro C.D., Flajnik M., Hendershot L.M., Sattler M., Groll M. & Buchner J. (2014) The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins. Proc Natl Acad Sci USA 111, 8155 - 8160. Feige M.J. & Buchner J. (2014) Principles and engineering of antibody folding and assembly. Biochimica et biophysica acta 1844, 2024 - 2031. Buchner J. & Kessler H. (2014) Protein folding by interaction. Structure 22, 936 - 937. Alvira S., Cuellar J., Rohl A., Yamamoto S., Itoh H., Alfonso C., Rivas G., Buchner J. & Valpuesta J.M. (2014) Structural characterization of the substrate transfer mechanism in Hsp70/Hsp90 folding machinery mediated by Hop. Nat Commun 5, 5484.