个人简介

Jan 1995 Dr. phil. nat. Universität Frankfurt, Germany Jul 1991 Diploma in chemistry, Universität Frankfurt, Germany 1986-1991 Study of Chemistry, University of Frankfurt, Germany

研究领域

Organic Chemistry and Biochemistry

The research of Prof. Sattler (b. 1965) focuses on the development and application of nuclear magnetic resonance (NMR) spectroscopy in solution. His aim is to describe the structure, dynamics and molecular interactions of biological macromolecules (proteins, RNAs with each other and with small molecules and drug-like compounds). This should lead to a better understanding of the basic molecular principles of fundamental biological processes and disease mechanisms.

近期论文

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Hennig J, Gebauer F, and Sattler M Breaking the protein-RNA recognition code. Cell Cycle,13:3619-20. [Pubmed] Dallmann A, and Sattler M Detection of hydrogen bonds in dynamic regions of RNA by NMR spectroscopy. Curr Protoc Nucleic Acid Chem 59, 7.22.1-7.22.19. [Pubmed] Zierer BK, Weiwad M, Rubbelke M, Freiburger L, Fischer G, Lorenz OR, Sattler M, Richter K, and Buchner J Artificial accelerators of the molecular chaperone hsp90 facilitate rate-limiting conformational transitions. Angew Chem Int Ed Engl 53, 12257-62. Hennig J, Militti C, Popowicz GM, Wang I, Sonntag M, Geerlof A, Gabel F, Gebauer F, Sattler M Structural basis for the assembly of the Sxl–UNR translation regulatory complex Nature, 515:287-90 [Pubmed] [Press release (Helmholtz)] [Press release (TUM)] Tripsianes K, Friberg A, Barrandon C, Brooks M, van Tilbeurgh H, Seraphin B, and Sattler M A Novel Protein-Protein Interaction in the RES (REtention and Splicing) Complex. J Biol Chem 289:28640-28650. [Pubmed] Schlundt A, Heinz GA, Janowski R, Geerlof A, Stehle R, Heissmeyer V, Niessing D, and Sattler M Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation. Nat Struct Mol Biol 21, 671-8. [Pubmed] [press release] Feige MJ, Gräwert MA, Marcinowski M, Hennig J, Behnke J, Ausländer D, Herold EM, Peschek J, Castro CD, Flajnik M, Hendershot LM, Sattler M, Groll M, Buchner J. The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins. Proc Natl Acad Sci U S A. 111, 8155-60 [Pubmed] [press release] Huang JR, Warner LR, Sanchez C, Gabel F, Madl T, Mackereth CD, Sattler M, Blackledge M. Transient Electrostatic Interactions Dominate the Conformational Equilibrium Sampled by Multidomain Splicing Factor U2AF65: A Combined NMR and SAXS Study. J Am Chem Soc. 136:7068-76. [Pubmed] Gobl C, Madl T, Simon B, and Sattler M NMR approaches for structural analysis of multidomain proteins and complexes in solution. Prog Nucl Magn Reson Spectrosc 80, 26-63. [Pubmed] Wang I, Hennig J, Jagtap PK, Sonntag M, Valcarcel J, and Sattler M Structure, dynamics and RNA binding of the multi-domain splicing factor TIA-1. Nucleic Acids Res.42:5949-6 [Pubmed] Hennig J, and Sattler M The Dynamic Duo: Combining NMR and Small Angle Scattering in Structural Biology. Protein Sci. 23(6):669-82 [Pubmed] Piccoli G, Onofri F, Cirnaru MD, Kaiser CJ, Jagtap P, Kastenmuller A, Pischedda F, Marte A, von Zweydorf F, Vogt A, Giesert F, Pan L, Antonucci F, Kiel C, Zhang M, Weinkauf S, Sattler M, Sala C, Matteoli M, Ueffing M, and Gloeckner CJ LRRK2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domain. Mol Cell Biol. 34(12):2147-2161 [Pubmed] Lorenz OR, Freiburger L, Rutz DA, Krause M, Zierer BK, Alvira S, Cuéllar J, Valpuesta JM, Madl T, Sattler M, Buchner J. Modulation of the Hsp90 Chaperone Cycle by a Stringent Client Protein. Mol Cell. 53(6):941-53 [Pubmed] Schilling F, Warner LR, Gershenzon NI, Skinner TE, Sattler M, Glaser SJ. Next-Generation Heteronuclear Decoupling for High-Field Biomolecular NMR Spectroscopy. Angew Chem Int Ed Engl. 53, 4475–4479. doi: 10.1002/anie.201400178