个人简介

Since 2007 Full Professor, Lehrstuhl Biochemie, Technische Universität München 2006 - 2007 Assistant Professor, Structural Biology, Charité, Berlin 2003 - 2006 Group Leader, Physiology, Ludwig-Maximilians-Universität, München 2000 - 2004 Habilitation, Institute of Biochemistry, Charité, Berlin

研究领域

Organic Chemistry and Biochemistry

Main research interests at our department are structural and biochemical characterization of multifunctional protein complexes, as well as elucidation of interaction mechanisms between proteins and natural ligands.

近期论文

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Marelli U. K., Frank A. O., Wahl B., La Pietra V., Novellino E., Marinelli L., Herdtweck E., Groll M. and Kessler H. (2014) Receptor-bound conformation of cilengitide better represented by its solution-state structure than the solid-state structure Chem. Eur. J., 2014, 20, 14201–6 Dubiella C., Cui H., Gersch M., Brouwer A. J., Sieber S. A., Krüger A., Liskamp R. M. J. and Groll M. Selective Inhibition of the Immunoproteasome by Ligand-Induced Crosslinking of the Active Site Angew. Chem. Int. Ed., 2014, 53, 11969–73 Voss C., Scholz C., Knorr S., Beck P., Stein M. L., Zall A., Kuckelkorn U., Kloetzel P.-M., Groll M., Hamacher K. and Schmidt B. α-Keto Phenylamides as P1'-Extended Proteasome Inhibitors ChemMedChem., 2014, 9, 2557-64 Beck P., Heinemeyer W., Späth A.-L., Elnakady Y., Müller R., Groll M. Interactions of the natural product kendomycin and the 20S proteasome J. Mol. Biol., 2014, 426, 3108-17 de Bruin G., Huber E. M., Xin B. T., van Rooden E. J., Al-Ayed K., Kim K. B., Kisselev A. F., Driessen C., van der Stelt M., van der Marel G. A., Groll M., Overkleeft H. S. Structure-based design of either ß1i oder ß5i specific inhibitors of human immunoproteasomes J. Med. Chem., 2014, 57, 6197-209 Arciniega M., Beck P., Lange O. F., Groll M., Huber R. Differential global structural cheanges in the core particle of the yeast and mouse proteasome induced by ligand binding Proc. Natl. Acad. Sci. USA, 2014, 111, 9479-84 Span I., Wang K., Eisenreich W., Bacher A., Zhang Y, Oldfield E., Groll M. Insights into the Binding of Pyridines to the Iron-Sulfur Enzyme ISPH J. Am Chem Soc., 2014, 22, 7926-32 Trivella D. B., Pereira A., Stein M. L., Byrum T., Valeriote F., Groll M., Gerwick W. H., Morre B. S. Enzyme inhibition by hydroamination: design and mechanism of a hybrid using a carmaphysin-syringolin enone proteasome inhibitor Chem. & Biol., 2014, 21, 782-91 Baer P., Rabe P., Fischer K., Citron C. A., Klapschinski T. A., Groll M., Dickschat J. S. Induced Fit Mechanism in Class I Terpene Cyclases Angew. Chem. Int. Ed., 2014, 53, 7652-6 Feige M. J., Gräwert M. A., Marcinowski M., Hennig J., Behnke J., Ausländer D., Herold E. M., Peschek J., Castro C. D., Flajnik M. F., Hendershot L. M., Sattler M., Groll M., Buchner J. The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins Proc. Natl. Acad. Sci. USA, 2014, 111, 8155-60 Quitterer F., Beck P., Bacher A., Groll M. The formation of Pyrroline and tetrahydropyridine rings in amino acids catalyzed by pyrrolysine synthase (PylD) Angew. Chem. Int. Ed., 2014, 53, 8150-3 Berthelmann A., Lach J., Gräwert M. A., Groll M., Eichler J. Versatile C3-symmetric scaffolds and their use for covalent stabilization of the foldon trimer Org. Biomol. Chem., 2014, 12, 2606-14 Weiz A. R., Ishida K., Quitterer F., Meyer S., Kehr J., Müller K., Groll M., Hertweck C., Dittmann E. Harnessing the Evolvability of Tricyclic Microviridins To Dissect Protease–Inhibitor Interactions Angew. Chem. Int. Ed., 2014, 53, 3735-8 Kunfermann A., Witschel M., Illarionov B., René M., Rottmann M., Höffken W., Seet M., Eisenreich W., Knölker H-J., Fischer M., Bacher A., Groll M., Diederich F. Pseudilins: Halogenated, Allosteric Inhibitors of the Non-Mevalonate Pathway Enzyme IspD Angew. Chem. Int. Ed., 2014, 53, 2235–9 Scharf D. H., Groll M., Habel A., Heinekamp T., Hertweck C., Brakhage A. A., Huber E. M. Flavoenzyme-Catalyzed Formation of Disulfide Bonds in Natural Products Angew. Chem. Int. Ed., 2014, 53, 2221–4 Stein M. L., Cui H., Beck P., Dubiella C., Voss C., Krüger A., Schmidt B., Groll M. Systematic Comparison of Peptidic Proteasome Inhibitors Highlights the α-Ketoamide Electrophile as an Auspicious Reversible Lead Motif Angew. Chem. Int. Ed., 2014, 53, 1679-83 Gersch M., Kolb R., Alte F., Groll M., Sieber S. A. Disruption of Oligomerization and Dehydroalanine Formation as Mechanisms for ClpP Protease Inhibition J. Am. Chem. Soc., 2014, 136, 1360−6 Baer P., Rabe P., Citron C. A., de Oliveira Mann C. C., Kaufmann N., Groll M., Dickschat J. S. Hedycaryol Synthase in Complex with Nerolidol Reveals Terpene Cyclase Mechanism ChemBioChem., 2014, 15, 213-6 List A., Zeiler E., Gallastegui N., Rusch M, Hedberg C, Sieber S. A., Groll M. Omuralide and Vibralactone: Differences in the Proteasome- β-Lactone-γ-Lactam Binding Scaffold Alter Target Preferences Angew. Chem. Int. Ed., 2014, 53, 571-4 Stein M. L., Groll, M. Applied techniques for mining natural proteasome inhibitors Biochim. Biophys. Acta., 2014, 1843, 26-38