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Gersch, M.*, Famulla, K.*, Dahmen M., Göbl, C., Malik, I., Richter, K., Korotkov, V. S., Sass, P., Rübsamen-Schaeff, H., Madl, T., Brötz-Oesterhelt, H., Sieber, S.A., "AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control",
Nature Communications, accepted.
Dahmen, M.*, Vielberg, M.-T.*, Groll, M., Sieber, S.A., "Structure and mechanism of the caseinolytic protease ClpP1/2 heterocomplex from Listeria monocytogenes",
Angew. Chem. Int. Ed. doi
Gersch, M., Hackl, M., Dubiella, C., Dobrinevski, A., Groll, M., Sieber S.A., "Intact protein mass spectrometry of 20S proteasomes reveals complex integrity, phosphorylation stoichiometry and inhibitor specificity",
Chemistry & Biology, accepted.
Artola, M., Ruiz-Avila, L.B., Vergoñós, A., Huecas, S., Araujo-Bazán, L., Martín-Fontecha, M., Vázquez-Villa, H., Turrado, C., Ramírez-Aportela, E., Hoegl, A., Nodwell, M., Barasoain, I., Chacón, P., Sieber, S.A., Andreu, J.M., López-Rodríguez, M.L., "Effective GTP-replacing FtsZ Inhibitors and Antibacterial Mechanism of Action",
ACS Chemical Biology doi
Rudolf*, G.C., Koch*, M.F., Mandl, F.A.M., Sieber, S.A., "Subclass-Specific Labeling of Protein-Reactive Natural Products with Customized Nucleophilic Probes",
Chemistry - A European Journal doi
Harvey, N.L., Krysiak, J., Chamni, S., Cho, S.W., Sieber, S.A., Romo, D., "Synthesis of (±)-Spongiolactone Enabling Discovery of a More Potent Derivative",
Chemistry - A European Journal doi
Kreuzer, J., Bach, N.C., Forler, D., Sieber, S.A., "Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition",
Chem. Sci. doi
Dubiella, C., Cui, H., Gersch, M., Brouwer, A.J., Sieber, S.A., Krüger, A., Liskamp, R.M.J., Groll, M., "Selective Inhibition of the Immunoproteasome by Ligand-Induced Crosslinking of the Active Site",
Angew. Chem. doi
Eirich, J., Braig, S., Schyschka, L., Servatius, P., Hoffmann, J., Hecht, S., Fulda, S., Zahler, S., Antes, I., Kazmaier, U., Sieber, S.A.*, Vollmar, A.M.*, "A small molecule protein disulfide inhibitor triggers chemosensitization of cancer cells",
Angew. Chem. doi
Wüstner, F., Mejías-Luque, R., Koch, M., Rath, E., Vieth, M., Sieber, S.A., Haller, D., Gerhard, M., "H. pylori γ-glutamyltranspeptidase impairs T lymphocyte function by compromising metabolic adaption through inhibition of cMyc and IRF4 expression",
Cellular Microbiology doi
Nodwell, M. B., Koch, M. F., Alte, F., Schneider, S., Sieber, S. A., "A Subfamily of Bacterial Ribokinases Utilizes a Hemithioacetal for Pyridoxal Phosphate Salvage",
J. Am. Chem. Soc. doi
Weinandy, F., Lorenz-Baath, K., Korotkov, V. S., Böttcher, T., Sethi, S., Chakraborty, T., Sieber, S. A., "A β-Lactone-Based Antivirulence Drug Ameliorates Staphylococcus aureus Skin Infections in Mice",
ChemMedChem, 2014. doi
Kunzmann, M. H., Bach, N. C., Bauer, B., Sieber, S. A., "α-Methylene-γ-butyrolactones attenuate Staphylococcus aureus virulence by inhibition of transcriptional regulation",
Chem. Sci., 2014. doi
Kolb, R., Bach, N.C., Sieber, S.A., "β-Sultams exhibit discrete binding preferences for diverse bacterial enzymes with nucleophilic residues",
ChemComm, 2014. doi
Gersch, M., Kolb, R., Alte, F., Groll, M., Sieber, S.A., "Disruption of oligomerization and dehydroalanine formation as mechanisms for ClpP protease inhibition",
J. Am. Chem. Soc., 2014. doi
List*, A., Zeiler*, E., Gallastegui, N., Rusch, M., Hedberg, C., Sieber, S.A., Groll, M., "Omuralide and Vibralactone: Differences in the Proteasome- β-Lactone-γ-Lactam Binding Scaffold Alter Target Preferences",
Angew. Chem., 2014. doi
Rudolf, G.C., Sieber, S.A., "Copper-Assisted Click Reactions for Activity-Based Proteomics: Fine-Tuned Ligands and Refined Conditions Extend the Scope of Application",
ChemBioChem, 2013. doi
Wolf, E., Zeißler, A., Vosyka O., Zeiler E., Sieber S.A., Verhelst S.H.L., "A New Class of Rhomboid Protease Inhibitors Discovered by Activity-Based Fluorescence Polarization",
PLOS ONE, 2013, 8(8), e72307. doi
Zeiler, E., List, A., Alte, F., Gersch, M., Wachtel, R., Poreba, M., Drag, M., Groll*, M., Sieber*, S.A., "Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad",
Proc. Natl. Acad. Sci. USA, 2013, 110(28), 11302-11307. doi