生举正 - 山东大学

个人简介

2013-今：副教授，山东大学，药学院，生化与生物技术药物研究所、国家糖工程技术中心 2009-2012：博士后，美国北卡罗来纳大学教堂山分校，药学院，药物化学及天然产物系，糖生物学课题组 2006-2009：博士研究生，山东大学，药学院，微生物与生化药学专业 2003-2006：硕士研究生，山东大学，生命科学学院，微生物技术国家重点实验室微生物遗传与分子生物学专业 1999-2003：本科，山东师范大学生命科学学院

研究领域

从事糖胺聚糖类药物仿生合成研究具体方向包括 1. 活性糖胺聚糖的发现、合成及活性研究 2. Leloir型糖基转移酶（Glycosyltransferase）的发现、研究及工具化改造 3. 活性糖分子的微生物制备

近期论文

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Zheng S, Hou J, Zhou Y, Fang H, Wang T-T, Liu F, Wang F-S, Sheng J-Z* (2018) One-pot two-strain system based on glucaric acid biosensor for rapid screening of myo-inositol oxygenase mutations and glucaric acid production in recombinant cells. Metabolic Engineering 49:212–219. doi:10.1016/j.ymben.2018.08.005 Wang T-T, Zhu C-Y, Zheng S, Meng C-C, Wang T-T, Meng D-H, Li Y-J, Zhu H-M, Wang F-S, Sheng J-Z* (2018) Identification and characterization of a chondroitin synthase from Avibacterium paragallinarum. Appl Microbiol Biotechnol 102:4785–4797. doi: 10.1007/s00253-018-8926-4 Li Y-J, Yin F-X, Zhang X-K, Yu J, Zheng S, Song X-L, Wang F-S, Sheng J-Z* (2018) Characterization of heparan sulfate N-deacetylase/N-sulfotransferase isoform 4 using synthetic oligosaccharide substrates. Biochimica et Biophysica Acta (BBA) - General Subjects 1862:547–556. Zhu H-M, Sun B, Li Y-J, Meng D-H, Zheng S, Wang T-T, Wang F-S, Sheng J-Z* (2018) KfoA, the UDP-glucose-4-epimerase of Escherichia coli strain O5:K4:H4, shows preference for acetylated substrates. Appl Microbiol Biotechnol 102:751–761. X. Zhang, F. Wang*, J. Sheng *, “Coding” and “Decoding”: hypothesis for the regulatory mechanism involved in heparan sulfate biosynthesis, Carbohydrate Research. 428 (2016) 1–7. F.-X. Yin, F.-S. Wang*, J.-Z. Sheng*, Uncovering the Catalytic Direction of Chondroitin AC Exolyase FROM THE REDUCING END TOWARDS THE NON-REDUCING END, J. Biol. Chem. 291 (2016) 4399–4406. J. Xue, L. Jin, X. Zhang, F. Wang, P. Ling, J. Sheng*, Impact of donor binding on polymerization catalyzed by KfoC by regulating the affinity of enzyme for acceptor, Biochimica et Biophysica Acta (BBA) - General Subjects. 1860 (2016) 844–855. Y. Xu, C. Cai, K. Chandarajoti, P.-H. Hsieh, L. Li, T.Q. Pham, E.M. Sparkenbaugh, J. Sheng, N.S. Key, R. Pawlinski, E.N. Harris, R.J. Linhardt, J. Liu*, Homogeneous low-molecular-weight heparins with reversible anticoagulant activity, Nat. Chem. Biol. 10 (2014) 248–250. J. Sheng, Y. Xu, S.B. Dulaney, X. Huang, J. Liu*, Uncovering biphasic catalytic mode of C5-epimerase in heparan sulfate biosynthesis, J. Biol. Chem. 287 (2012) 20996–21002. J. Sheng, R. Liu, Y. Xu, J. Liu*, The Dominating Role of N-Deacetylase/N-Sulfotransferase 1 in Forming Domain Structures in Heparan Sulfate, J. Biol. Chem. 286 (2011) 19768–19776.