宋淳 - 山东大学

个人简介

学习和工作经历 1997.11-2001.11， Brigham Young University ，有机化学 (导师：Merritt B. Andrus) ，哲学博士生。 1990.09-1993.07，山东大学，化学系，有机化学理学硕士。 1985.09-1988.07，济南大学，化学系，环境监测。工作经历 2011 - 至今，国家重大新药创制中心/山东大学药物制剂与释药系统研究中心/山东大学药学院，教授，博士生导师，山东省泰山学者海外特聘专家。 2001- 2011，历任，辉瑞制药，日东电工美国生物研发公司及诺华制药，科学家，资深科学家，研究团队负责人和/项目主管人，主要从事siRNA为基础的基因治疗课题研究，针对肺部疾病和代谢性疾病的小分子药物研究，可靶向生物降解的纳米药物传输体系的研究。

研究领域

1. 针对特定肿瘤靶点的小分子化学药物研究：如计算机模拟设计Hsp90抑制剂的抗肿瘤研究。 2. 脐带血干细胞的体外扩增及临床应用研究。 3. 新型可生物降解的纳米材料的生物医学应用研究：如肿瘤探针和药物/基因/抗体的传输。 4. 特定肿瘤生物标记物的诊断学研究：如以外周血为基础的特定妇科肿瘤学研究；肿瘤起始细胞/肿瘤干细胞的特征研究。 5. 氮杂环卡宾（NHC）催化体系在有机合成化方法学中研究。

近期论文

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1、Niu, Z; Chen, J; Chen, Z; Ma, M; Song, C; Ma, Y,“Application of BidentateOxazoline-Carbene Ligands with Planar and Central Chirality in Asymmetric â-Boration of á,â-Unsaturated Esters”.J. Org. Chem., 2015, 80 (1), 602–608. 2、Chen, J; Yang, S; Chen, Z; Song,C; Ma, Y.“Synthesis of novel macrocyclic planar chiral carbene-Ag complexes derived from [2.2]paracyclophane for Rh-catalyzed asymmetric 1,2-additions of arylboronic acids to aromatic aldehydes”.Tetrahedron: Asymmetry2015，26， 288–295. 3、Deng, M; Lu, Z; Zheng, J; Wan, X; Chen, X;Hirayasu, K; Sun, H; Lam, Y; Chen, L; Wang, Q; Song, C; Huang, N;Gao, G; Jiang, Y; Arase, H; Zhang CC.“A motif in LILRB2 critical for Angptl2 binding and activation.”Blood 2014,124(6), 924-35. 4、Zhao, L; Ma, Y; He, F; Duan, W; Chen, J; Song, C .”Enantioselective â-Boration of Acyclic Enones by a [2.2]Paracyclophane-Based N-Heterocyclic Carbene Copper (I) Catalyst”. J. Org. Chem. 2013, 78(4), 1677-1681. 5、Chen, X; Zheng, J; Zou, Y; Song, C; Hu, X; Zhang, CC.“IGF binding protein 2 is a cell-autonomous factor supporting survival and migration of acute leukemia cells.” Journal of hematology & oncology 2013,6(1), 72. 6、Duan, W; Ma, Y; He, F; Zhao, L; Chen, J; Song, C. “Synthesis of novel planar chiral Ag and Rh N-heterocyclic carbene complexes derived from [2.2]paracyclophane and their application in ultrasound assisted asymmetric addition reactions of organoboronic acids to aldehydes.”Tetrahedron: Asymmetry 2013, 24(5-6), 241-248. 7、Lu, Y; Ma, Y; Yang, S; Ma, M; Chu, H; Song, C. “Synthesis of planar chiral [2.2]paracyclophane-based amino thioureas and their application in asymmetric aldol reactions of ketones with isatins.” Tetrahedron: Asymmetry 2013, 24(18), 1082-1088. 8、Wang, D; Ma, Y; He, F; Duan, W; Zhao, L; Song, C. “Synthesis of Planar Chiral [2.2]ParacyclophanylImidazo[1,5-a]pyridinium Salts for the Rhodium-CatalyzedAsymmetricArylation.” Synthetic Communications 2013, 43(6), 810-825. 9、Zhao, L; Ma, Y;Duan, W; He, F; Chen, J; Song, C. “Asymmetric â-Boration of á,â-Unsaturated N-Acyloxazolidinones by [2.2]Paracyclophane-Based Bifunctional Catalyst.”Org.Lett.2012Nov 6. 10、He, F; Ma, Y; Zhao, L;Duan, W; Chen, J; Song, C.. “Planar chirality change in dediazoniation reactions of paracyclophanes and mechanistic implication.” Org. Lett. 2012, 14(21), 5436-5439.