赵忠熙 - 山东大学

个人简介

1980-1984：山东大学化学系，获理学学士学位 1984-1987：山东大学化学系，获理学硕士学位 1989-1993：美国杨伯翰大学(Brigham Young University)生化系，获化学博士学位 1993-1995：美国太平洋西北国家实验室(Pacific Northwest National Lab)博士后研究员 1987-1989：山东大学化学系助教 1995-2002：美国默克公司 (Merck & Co.)，药物研究开发部研究学者 2002-2009：美国美达贝斯治疗公司 (Metabasis Therapeutics)，药物开发部部长、总监 2010至今：山东大学药物制剂与释药系统研究中心，国家特聘教授、中心主任

研究领域

1、药剂学：吸入、缓控释、靶向纳米、脂质体、膜制剂等新型给药系统的研究； 2、药物分析及生物药剂学：药物分析和生物分析技术研究，新型制剂生物药剂学评价； 3、新药创制：治疗肺结核、慢阻肺、肺癌、胃癌等抗结核、抗肿瘤原创药物的研发； 4、功能食品研发：大蒜和红枣有效成分相关基础研究及其食品药品开发。

近期论文

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1. F. Zhang, Y. Zhang, K. Wang, X. Zhu, G. Lin, Z. Zhao*, S. Li, J. Cai, J. Cao, Diallyl trisulfide inhibits naphthalene-induced oxidative injury and the production of inflammatory responses in A549 cells and mice, Int. Immunopharmacol., in press. 2. Y. Zhang, Y. Wang, F. Zhang, K. Wang, G. Liu, M. Yang, Y. Luan, Z. Zhao*, J. Zhang, X. Cao, D. Zhang, Allyl methyl disulfide inhibits IL-8 and IP-10 secretion in intestinal epithelial cells via the NF-кB signaling pathway, Int. Immunopharmacol., 2015, 27, 156-163. 3. G. Liu, X. Liu, Y. Zhang, F. Zhang, T. Wei, M. Yang, K. Wang, Y. Wang, N. Liu, H. Cheng*, Z. Zhao*, Hepatoprotective effects of polysaccharides extracted from Zizyphus jujube cv. Huanghetanzao, Int. J. Bio. Macromol., 2015, 76, 169–175. 4. Y. Wang, X. Liu, J. Zhang, G. Liu, Y. Liu, K. Wang, M. Yang, H. Cheng*, Z. Zhao*, Structural characterization and in vitro antitumor activity of polysaccharides from Zizyphus jujuba cv. Muzao, RSC Advances, 2015, 5, 7860 – 7867. 5. X.-Q. Liu, M. Yang, H.-L. Cheng*, Z.-X. Zhao*, Preparation and Characterization of Capsule Formulations of Polysaccharides from Zizyphus Jujuba cv. Huanghetanzao, Chinese J. Biochem. Pharm., 2014, 34, 162. 6. H. Zhang, K. Wang, G. Lin* and Z. Zhao*, Antitumor mechanisms of S-allyl mercaptocysteine for breast cancer therapy, BMC Complem. Altern. Med., 2014, 14, 270. 7. J. Hao, Y. Gao, J. Zhao, J. Zhang, Q. Li, Z. Zhao*, and J. Liu*, Preparation and Optimization of Resveratrol Nanosuspensions by Antisolvent Precipitation Using Box-Behnken Design, AAPS PharmSciTech, 2014, DOI: 10.1208/s12249 -014-0211-y. 8. Y. Liu, D. Zhao and Z. Zhao*, Study of degradation mechanisms of cyclobenzaprine by LC-MS/MS”, Anal. Methods, 2014, 6, 2320. 9. T. Wei, G. Lin*, L. Liu and Z. Zhao*, Study of Antimicrobial Effects of Different Types of Glycyrrhiza Extracts by Microcalorimetry, Bull. Korean Chem. Soc., 2014, 35, 2640.