娄红祥 - 山东大学

个人简介

1981年8月— 1985年7月：山东医学院药学系，学士学位 1985年8月—1988年7月：山东省医学科学院药物研究所，硕士学位 1988年8月—1991年7月：沈阳药科大学，博士学位 1991年7月—1993年7月：山东医科大学药学系，讲师 1993年8月—1995年7月：山东医科大学药学系，副教授 1995年8月—2000年7月：山东医科大学药学院，教授期间于1997年3月至1998年11月在日本国立生命工业技术研究所访问研究 2000年7月至今：山东大学药学院，教授

研究领域

1. 苔藓植物、药用植物及其内生真菌活性代谢产物的发现 2. 天然产物的抗真菌和抗肿瘤活性机制及逆转耐药作用机制研究 3. 重要活性天然产物的化学合成和结构修饰研究 4. 重要活性天然产物的生物合成规律及调控研究

近期论文

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Wang HH, Li G, Qiao YN, Sun Y, Peng XP, and Lou HX*, Chamiside A, a Cytochalasan with a Tricyclic Core Skeleton from the Endophytic Fungus Chaetomium nigricolor F5. Org. Lett. 2019, 21, 3319-3322 Wenqiang Chang, Jun Liu, Ming Zhang, Hongzhuo Shi, Sha Zheng, Xueyang Jin, Yanhui Gao, Shuqi Wang, Aiguo Ji and Hongxiang Lou*. Efflux pump-mediated resistance to antifungal compounds can be prevented by conjugation with triphenylphosphonium cation. Nature communications, 2018, 9:5102. Jingjing Han#, Jiaozhen Zhang#, Rongxiu Zhu, Yi Li, Yanan Qiao, Yun Gao, Xueyang Jin, Wang Chen, Jinchuan Zhou, and Hongxiang Lou*. Plagiochianins A and B, Two ent-2,3-seco-Aromadendrane Derivatives from the Liverwort Plagiochila duthiana. Organic Letters, 2018, 20(20): 6550-6553. Hongbo Zheng, Yifeng Wu, Bin Sun, Chuanle Cheng, Yanan Qiao, Yuehua Jiang, Shengtian Zhao, Zhiyu Xie, Jing Tan, Hongxiang Lou. Discovery of Furyl/Thienyl β-carboline Derivatives as Potent and Selective PDE5 Inhibitors with Excellent Vasorelaxant Effect. Eur. J. Med. Chem. 2018, 158, 767-780. Hongbo Zheng, Lin Li, Bin Sun, Yun Gao, Wei Song, Xiaoyu Zhao, Yanhui Gao, Zhiyu Xie, Nianzhao Zhang, Jianbo Ji, Huiqing Yuan, HongxiangLou. Design and Synthesis of Furyl/Thineyl Pyrroloquinolones Based on Natural Alkaloid Perlolyrine, Lead to the Discovery of Potent and Selective PDE5 Inhibitors. Eur. J. Med. Chem. 2018, 150, 30–38. Cheng AX, Zhang X, Han XJ, Zhang YY, Gao S, Liu CJ*, Lou HX* (2017) Identification of chalcone isomerase in the basal land plants reveals an ancient evolution of enzymatic cyclization activity for synthesis of flavonoids. New Phytol. doi:10.1111/nph.14852 Zhou J, Zhang J, Li R, Liu J, Fan P, Li Y, Ji M, Dong Y, Yuan H, &Lou H* (2016). Hapmnioides A–C, Rearranged Labdane-Type Diterpenoids from the Chinese Liverwort Haplomitriummnioides. Organic letters, 18(17), 4274-4276. Zheng H, Dong Y, Li L, Sun B, Liu L, Yuan H, &Lou H* (2016). Novel benzo [a] quinolizidine analogs induce cancer cell death through paraptosis and apoptosis. Journal of medicinal chemistry, 59(10), 5063-5076. Jun Liu, Bin Sun, Xiaoyu Zhao, Jie Xing, Yanhui Gao, Wenqiang Chang, Jianbo Ji, Hongbo Zheng, Changyi Cui, Aiguo Ji*, Hongxiang Lou* (2017) Discovery of potent orally active protase-activated receptor 1 (PAR1) antagonist based on andrographolide, Journal of Medicinal Chemistry, 60, 7166-7185. Lin ZM, Guo YX, Gao YH, Wang SQ, Wang XN, Xie ZY, Niu HM, Chang WQ, Liu L, Yuan HQ, Lou HX*. ent-Kauranediterpenoids from Chinese liverworts and their antitumor activities through Michael addition as detected in situ by a fluorescence probe. J Med Chem, 2015, 58, 3944-3956. Zhou JC, Zhang JZ, Cheng AX, Xiong YX, Liu L, Lou HX*. Highly rigid labdane-type diterpenoids from a Chinese liverwort and light-driven structure diversification. Org Lett, 2015,17, 3560-3563. Wang LN, Zhang JZ, Li X, Wang XN, Xie CF, Zhou JC, Lou HX*. Pallambins A and B, unprecedented hexacyclic 19-nor-secolabdane diterpenoids from the Chinese liverwort Pallaviciniaambigua. Org Lett, 2012, 14, 1102-1105. Zhang JZ, Zhu RX, Li G, Wang LN, Sun B, Chen WF, Liu L, Lou HX*. Interconversion of the pallambins through photoinduced rearrangement. Org. Lett. 2012, 17, 3560-3563. Chang W, Zhang M, Li Y, Lou H*. A flow cytometry based method to detect persisters in Candida albicans. Antimicrob Agents Chemother, 2015, 59, 5044-5048.